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Layered van der Waals magnets like CrSBr, when sandwiched between electrodes form a natural magnetic tunnel junction, albeit lacking the characteristic nonmultiple volatile states at zero field of a magnetic memory. Here, Chen et al overcome this limitation to establish four nonvolatile states at zero field by constructing magnetic tunnel junctions out of twisted monolayers and bilayers of CrSBr with two twisted interfaces.

An anti-HIV-1 antibody that targets an N332_gp120 glycan-independent V3 epitope, a site of Env vulnerability, can decline viremia in HIV-1-infected humanized mice while overcoming classical V3 escape mutations.

Electron spins in diamond allow magnetometry with high sensitivity, but the bandwidth in the microwave regime is limited to a narrow band around their resonance frequency. Here, the authors solve this problem by coupling the spins to a thin film of yttrium iron garnet, exploiting the non-linear spin-wave dynamics of the magnet.

Hole spin semiconductor qubits suffer from charge noise, but now it has been demonstrated that placing them in an appropriately oriented magnetic field can suppress this noise and improve qubit performance.

Scanning dielectric microscopy of nanocapillaries filled with water reveals that interfacial and strongly confined water exhibits a large in-plane dielectric constant and an in-plane conductivity approaching superionic values. 

Current applications of NV centers in diamond as spin-photon interfaces for quantum networks are limited by low coherent photon emission. Here, the authors integrate a coherently controlled NV spin qubit with an open microcavity to achieve Purcell-enhanced emission and demonstrate spin-photon state generation.

Across qubit platforms, improving coherence often compromises operational speed. Here, the authors overcome this trade-off by electrically controlling a hole spin qubit in a Ge/Si core/shell nanowire, achieving triple manipulation speeds while quadrupling coherence times.

Reconfigurable arrays of up to 448 neutral atoms are used to implement and combine the key elements of a universal, fault-tolerant quantum processing architecture and experimentally explore their underlying working mechanisms.

There is considerable interest in generating broadband frequency combs at terahertz frequencies. Here, Tammaro et al.achieve this using coherent synchrotron radiation where the electron bunches emit quasi-synchronous terahertz pulses with high power, broad frequency, zero frequency offset, and high density.

Graphene transistors are attractive for many applications but making integrated circuits without degrading their characteristics is proving challenging. Here, the authors demonstrate a radio frequency integrated receiver using a graphene-last approach compatible with conventional processing methods.

Microwaves are of interest for applications such as communications, radar and metrology. Here, Li et al. demonstrate an on-chip microresonator device for the generation of microwaves by optical means, instead of the usual electronic devices.

Advances in nanoelectromechanical systems have brought improvements in the quality factor of nanomechanical resonators, yet few low-loss transduction schemes exist at high temperature. Using non-dissipative dielectric coupling to a microwave cavity, Faustet al. present an integrated nanomechanical transducer.

Hexagonal boron nitride (h-BN) has been used extensively to encapsulate other van der Waals materials, protecting them from environmental degradation, and allowing integration into more complex heterostructures. Here, the authors make use of boron vacancy spin defects in h-BN using them to image the magnetic properties of a Fe₃GeTe₂ flake.

Frequency metrology lies at the heart of precision measurement. Here, authors establish a phasecoherent frequency link across microwave, optical, and free-electron domains. This bridges electromagnetic waves and electron matter waves, advancing ultrahigh-precision electron spectroscopy.

Spin–torque oscillators have potential as nanosized microwave signal generators, but presently they are limited by their small output power. Here, the authors develop a cheap lithographic method to fabricate spin–torque oscillators, which can be mutually synchronized to overcome the output-power limitation.

A successful silicon spin qubit design should be rapidly scalable by benefiting from industrial transistor technology. This investigation of exchange interactions between two FinFET qubits provides a guide to implementing two-qubit gates for hole spins.

Here, the authors generate dissipative Kerr solitons with stable repetition rates and low optical power threshold. They achieve this by actively switching the bias current of injection-locked III-V semiconductor lasers and pulse-pumping crystalline and integrated microresonators with picosecond laser pulses.

Optical reference cavities are important in precision time keeping and low-noise microwave generation. Here as a step towards their miniaturization, the authors demonstrate a chip-based reference cavity that uses a spiral geometry to improve stability by introducing thermal and mechanical immunity.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Integrating a thin-film resistance thermometer above a high-Q SiN microresonator enables local temperature monitoring and active stabilization of its resonance wavelength. The emission wavelength of a distributed feedback laser locked to the microresonator fluctuates within 0.5 pm over a period of 50 h.

Magnetic phase transitions typically lead to changes in a materials magnetostrictive properties. Here, Šiškins et al use the motion of a nanodrum to study the nonlinear magneto-mechanical response of FePS₃, and observe changes in the nonlinear stiffness and damping near the Neel temperature.

Nanophotonic microwave synthesizers in the X-band (10 GHz, for radar) and K-band (20 GHz, for 5G), based on integrated soliton microcombs driven by a low-noise fibre laser, link the fields of microwave photonics and integrated microcombs.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

A field-programmable radio frequency surface (FPRFS) is proposed that can implement arbitrary antennas and impedance matching networks. An asymmetric excitation scheme is demonstrated to ensure radiation efficiency independent of the number of FPRFS switches.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Klein and colleagues characterize 04_A06, a new V_H1-2-encoded broadly neutralizing antibody that has marked breadth and potency against extended multiclade HIV-1 pseudovirus panels and can maintain full viral suppression in HIV-1-infected humanized mice.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

A turn-key-operable hybrid integrated Pockels laser based on an external distributed Bragg waveguide grating reflector fabricated in a wafer-scale thin-film lithium niobate on insulator platform is demonstrated, with a tuning efficiency of over 550 MHz V^–1, tuning rates reaching the exahertz per second, and a high output power of 15 mW.

Here, the authors show that integration of metamaterial and optical fibre technologies enables all-optical XOR, NOT and AND logical functions that are performed at up to 40 gigabits per second with few femtojoules per bit energy consumption within a coherent fully fiberized network.

The authors report the sweet-spot operation of germanium hole spin qubits, exploring the optimization of the external magnetic field orientation, the g-tensor and its electric tunability, and hyperfine interactions.

Multifilament surgical sutures functionalized with a conductive polymer and incorporating pledgets with capacitive sensors operated via radiofrequency identification can be used to monitor physicochemical states of deep surgical sites.

26-methylstigmastane, a new fossil sterane biomarker sourced from demosponges, evidences Precambrian animals in marine shelf settings.

By controlling the current and measuring the voltage via the fibre, a hybrid electronic–photonic sensor consisting of a p–i–n junction located on the fibre-tip junction can be used as an electrical sensor with optical readout.

The integration of 1,024 independent silicon quantum dot devices with on-chip digital and analogue electronics, all of which operate below 1 K, allows characteristic data across the quantum dot array to be acquired and analysed in under 10 min.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Currently, genetically encoded calcium indicators are not suitable for direct quantification. Here the authors engineer a fluorescence lifetime imaging calcium biosensor, Turquoise Calcium Fluorescence LIfeTime Sensor (Tq-Ca-FLITS), and measure intracellular calcium concentrations in human-derived organoids.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.