Search

The milli-spinner thrombectomy facilitates fast, complete clot removal by using spinning-induced compression and shear forces to mechanically modify the clot microstructure through densifying the fibrin network and releasing red blood cells, thus reducing clot volume.

CMOS-based circuits can be integrated with silicon-based spin qubits and can be controlled at milli-kelvin temperatures, which can potentially help scale up these systems.

While the electronic quality of graphene has significantly improved during the last two decades, charged defects inside encapsulating crystals still limit its performance. Here, the authors overcome this limitation and report the enhanced electronic quality of graphene enabled by tuneable Coulomb screening inside large-angle twisted bilayer and trilayer graphene devices, showing Landau quantization at magnetic fields down to ~5 mT.

The acetyl-CoA pathway is the most ancient CO₂ fixation pathway in nature. Here, the authors show that metals selectively reduce CO₂ to the intermediates and end-products of the acetyl-CoA pathway, which is consistent with a prebiotic origin of this pathway.

In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their progenitors in the bone marrow.

Changes in Southern Ocean circulation have preceded shifts in the Atlantic Meridional Overturning Circulation in the North Atlantic over the past 1,300 years, according to an analysis of bamboo coral records from the southwest Pacific.

A tissue-engineered esophageal segment is functional in minipigs.

In mice, a low-protein diet leads to a gut-microbiota-driven remodelling of adipose tissue towards brown fat, showing that gut microorganisms have a role in detecting and responding to a lack of protein.

The use of antimicrobial agents can exacerbate the proliferation of antimicrobial resistance genes, which can put public health at risk; evaluating this risk requires proper monitoring. An extensive investigation of Australian wastewater reveals a distinct correlation between the type of antimicrobial used and the socioeconomic status of the population.

Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

Understanding how precise atomic structures govern catalytic activity remains a fundamental challenge. Now it has been shown that framework-encapsulated, molecularly defined polyoxometalate clusters enable clear structure–activity correlations and catalyse low-temperature CO₂ hydrogenation to methanol.

While auxin typically inhibits root cell growth, elevated temperatures reconfigure the auxin transcriptional pathway to promote elongation. This study reveals how plants reprogram core hormonal signalling to adjust their internal biology to rising temperatures.

The relationship between the driving force for electron transfer in organic photovoltaic (OPV) materials and their performance has been challenging to understand. Now, it has been shown that the driving force controls the charge-transfer distance at the donor–acceptor interface, a finding that supports a model where raising the dielectric constant will be the most effective way to improve OPV efficiencies.

An approach combining BONCAT, stable isotope probing and metaproteomics showcases the hidden metabolic interconnectivity of microorganisms within an anaerobic digestion community.

Polymersomes with surface-integrated nanoparticles have potential in a range of applications, but are challenging to prepare. Here, the authors report a method for the preparation of such polymersomes by a hierarchical phase separation approach.

We report the production of MoS₂ nanosheets with high phase purity, showing that the 2H-phase templates facilitate epitaxial growth of Pt nanoparticles, whereas the 1T′ phase supports single-atomically dispersed Pt atoms.

Mussels are masters of sticking on wet surfaces. Here, authors discover a histidine-rich coiled coil protein in mussel glue that challenges the prevailing understanding of how mussel stick tight, with the findings relevant to the design of improved glues.

CFAP20 has a key role in rescuing RNA polymerase II complexes that have arrested during DNA transcription, limiting the accumulation of R-loops and preventing collisions between the transcription and replication machinery.

In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship between environmental antigen exposure and subsequent allergy.

The authors introduce a deep learning pipeline integrating classification, ranking, and regression modules, in which each module is trained via a few-shot learning strategy involving pretraining and multiple fine-tuning steps, to identify potent AMPs against Acinetobacter baumannii.

TDP-43 pathology is a key event in ALS/FTD and selectively affects specific neurons in the motor cortex. Here, the authors report which neuron types are affected and demonstrate that transcriptomic changes are cell-type specific.

A solar-powered methodology facilitated by the rational design of a photocatalyst enables efficient defluorination of structurally diverse per- and polyfluoroalkyl substances, thereby establishing a sustainable strategy for the environmental remediation of these recalcitrant contaminants.

Ticks adhere firmly to their host by secreting a protein-rich saliva that eventually forms a solid bioadhesive, but the mechanism underlying this phase transition is not understood. Now it has been shown that a disordered glycine-rich protein present in tick saliva undergoes liquid–liquid phase separation, followed by a liquid-to-gel transition, and exhibits adhesive properties.

Oriented growth is an important pathway for crystal growth. Here, the authors show that gibbsite nanoplates form mesocrystals through directed sliding and staggered stacking, as demonstrated by in situ microscopy and molecular simulations.

A method is described for the manufacture of pivoting colloidal assemblies comprising rotating diamond and rotating triangle geometries that show tunable folding and unfolding by thermal fluctuations and actuation by magnetic attractions.

Hyperpolarized ¹³C-enriched pyruvate has demonstrated promise for imaging metabolism in cancer, heart disease and neurodegenerative disorders; however, broader clinical adoption is constrained by the cost and limited availability of current hyperpolarization technology. Here, the authors report in situ hyperpolarization of pyruvate at 6.5mT by SLIC SABRE, demonstrating its application in low-cost high-performance ¹³C MRI at milli Tesla fields with sufficient resolution to distinguish chemical shifts between pyruvate isotopomers.

Phylogenetic and functional analyses across 34 Lepidoptera and 183 plant species show that hexenal isomerases found in Lepidoptera exhibit functional convergence with those found in plants despite having evolved independently from unrelated enzyme families.

Rearrangements govern many properties of materials and molecules, but it has been largely unexplored how to create flexible structures from the bottom up. Here, the authors use colloidal particles to explore how to guide the kinetic self-assembly pathways into ordered structures that maintain flexibility.

Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Creating durable, motion-compliant neural interfaces is essential for accessing dynamic tissues in vivo and linking neural activity with behaviors. Here, the authors introduce carbon nanotube-enhanced polyvinyl alcohol hydrogels, creating electrically anisotropic, fatigue-resistant fibers for long-term intraspinal electrophysiological recordings in mice.

Biomolecules can control biochemical reactions via droplets of macromolecules known as condensates. Here, it is shown that oxygen is partially excluded from such condensates due to the high concentration of macromolecules.

Ferroptosis is an iron-dependent lipid peroxidation-mediated form of cell death that holds promise for targeting treatment-resistant cancer cells. Here, the authors show that AMPK-mediated lipid droplet dynamics modulates the response to ferroptosis inducers in melanoma.

The mantle upwelling beneath the Afar rift may be influenced by tectonic processes in the overriding lithospheric plates that shape the distribution of both the compositional heterogeneities and abundance of melt, according to a geochemical and statistical study of volcanic samples.

Authors study links between amyloid secondary nucleation and growth defects, demonstrating these sites on Aβ40/Aβ42 fibrils are rare compared to the number of protein molecules. Re-analysis of published data suggests that defects may also drive secondary nucleation generally.

How cellular metabolism influences tissue-resident macrophage survival is currently unknown. The authors here demonstrate that SerpinB2 regulates mitochondrial function to promote tissue-resident macrophage survival.

Synthetic cells, modular gene-expressing compartments, have shown promising applications in biology and medicine; however, more diverse tools are required for their control and communication. Now, photocaged promoters and cell-free synthesis of an acyl homoserine lactone have been used to demonstrate light-activated communication between synthetic cells and living cells.

The xylosyltransferase isoenzymes XT1 and XT2 catalyze the first glycosylation step in the biosynthesis of proteoglycans. Now, bump-and-hole engineering of XT1 and XT2 enables substrate profiling and modification of proteins as designer proteoglycans to modulate cellular behavior.

Delivering immunomodulatory compounds to myeloid cells can activate innate immunity for cancer immunotherapy. Here the authors design a polymersome-based nanocarrier for delivering β-glucan to red pulp myeloid cells in the spleen and show that their strategy achieves tumour growth reduction in a melanoma model.

Green hydrogen production via water electrolysis requires a low-cost solution to provide efficient catalysts. Here, the authors report an industrially scalable method for synthesizing NiFe layered double hydroxide at room temperature and atmospheric pressure, enhancing alkaline electrolysis.

Large single crystals of charged 2D polymers are synthesized on a water surface, under kinetic control, by the irreversible Katritzky reaction. The crystals can act as an anion-selective membrane for osmotic energy generation.

Filamin C is a key actin-binding protein involved in cardiomyopathies and musculoskeletal disorders. Here, Wang et al reveal that it interacts with the heat shock protein HSPB7 under biomechanical stress, forming a stable hetero-dimer which is regulated by phosphorylation.

Labrijn et al. describe the generation of bispecific antibodies through controlled Fab-arm exchange, involving separate expression of two parental IgG1s containing single matching point mutations, followed by recombination of the 'half molecules'.

Here the authors show that antibiotic resistance genes peak in the gut at the age of 6 months, and that beneficial bifidobacteria produce aromatic lactic acids that actively inhibit antimicrobial resistant bacteria, suggesting that boosting these microbes may help curb antimicrobial resistance.

Blastema formation is a critical early step during regeneration, but how it is initially formed is still unclear. Here, they find soxC and mmpReg promote blastema formation in fragmenting potworms, and identify similar expression dynamics in tadpole tail, suggesting a conserved mechanism.

In this study, the authors designed potent Enterovirus D68 capsid inhibitors that block viral binding and show that the lead compounds reduce virus levels, prevent paralysis and improve survival in EV-D68-challenged mice, even when treatment starts days after infection.

Cyanide, a known plant defence compound, can also stimulate seed germination. Flemattiet al. show that glyceronitrile is produced in wildfire smoke, which can release cyanide and stimulate seed germination of fire-responsive plant species, thus serving as an ecological store of cyanide.

This protocol describes the establishment of a reversible replication barrier using plasmid templates containing a lacO array bound by LacR repressor. The method allows fine control of replication fork movement and replication fork encounter with DNA lesions.

An increasing prevalence of Gram-negative bacteria increases the interest in nanotherapies to treat antibiotic resistance. Here, the authors examine the antimicrobial activity of polymyxin-loaded cubosomes and explore a polytherapy treatment of pathogens with cubosomes in combination with polymyxin.