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Scientific Reports (44)
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Showing 1–50 of 74 results

Advanced filters: Author: Jae-Sung You Clear advanced filters

Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury

An early event after lung injury is extracellular matrix remodelling. Here, the authors show that thrombospondin-1 (TSP1) from megakaryocytes/platelets protects the lung’s extracellular matrix, particularly basement protein COL6. Mice without TSP1 had greater lung damage and neutrophil activity, showing TSP1 reduces injury severity.

Hernán F. Peñaloza
Atish Gheware
Janet S. Lee
ResearchOpen Access12 Mar 2026
Nature Communications

Volume: 17, P: 1-16
Influence of thermocycling on the antifungal properties of 3D printed denture base material containing zwitterionic and quaternary ammonium compounds

Sae-Eun Lee
Jae-Sung Kwon
ResearchOpen Access12 Nov 2025
Scientific Reports

Volume: 15, P: 1-9
HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease

The blood ApoM-S1P complex regulates vascular functions, but its role in neurogenic niches remains unclear. Here, the authors show that the blood ApoM-S1P complex preserves V-SVZ homeostasis and protects against early features of Alzheimer’s disease.

Byung Jo Choi
Ju Yeon Hong
Hee Kyung Jin
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-22
Identification of a resistance-exercise-specific signalling pathway that drives skeletal muscle growth

This study demonstrates that the MKK3b/6 signalling pathway drives the skeletal muscle growth-promoting effects of resistance exercise.

Wenyuan G. Zhu
Aaron C. Q. Thomas
Troy A. Hornberger
Research15 May 2025
Nature Metabolism

Volume: 7, P: 1404-1423
Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel

Connexin 36 (Cx36) gap junction channel is responsible for signal transmission in electrical synapses. Here, the authors determine cryo-EM structures of Cx36, providing insights into a potential role of lipids in the channel gating.

Seu-Na Lee
Hwa-Jin Cho
Hyung Ho Lee
ResearchOpen Access11 Mar 2023
Nature Communications

Volume: 14, P: 1-15
Distinctive CD39⁺CD9⁺ lung interstitial macrophages suppress IL-23/Th17-mediated neutrophilic asthma by inhibiting NETosis

Interstitial macrophages (IM) are a specialised population of macrophage cells in the lungs which regulate lung inflammation. Here using mouse models, the authors show that a CD39⁺CD9⁺ IM population reduce IL-23/Th17 driven neutrophilic inflammation through suppression of NETosis.

Seunghan Han
Bomin Kim
Ji-Hwan Ryu
ResearchOpen Access04 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Influence of various cleaning solutions on the geometry, roughness, gloss, hardness, and flexural strength of 3D-printed zirconia

HongXin Cai
Min-Yong Lee
Jae-Sung Kwon
ResearchOpen Access29 Sept 2024
Scientific Reports

Volume: 14, P: 1-10
Occlusive membranes for guided regeneration of inflamed tissue defects

Symbiosis should be maintained during the oral regeneration period. Herein, authors develop an occlusive membrane that induces symbiosis, thereby improving the performance of guided bone generation therapy.

Woojin Choi
Utkarsh Mangal
Jinkee Hong
ResearchOpen Access24 Nov 2023
Nature Communications

Volume: 14, P: 1-14
Adenine base editor engineering reduces editing of bystander cytosines

Engineered variants of adenine base editors have reduced cytosine base editing or a specific C-to-G base editing activity.

You Kyeong Jeong
SeokHoon Lee
Sangsu Bae
Research01 Jul 2021
Nature Biotechnology

Volume: 39, P: 1426-1433
Narrative mobile video game-based cognitive training to enhance frontal function in patients with mild cognitive impairment

Yeseul Choi
Jae-Sung Lim
Dong-Wha Kang
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-8
Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain

While prime editing is a promising technology, PE2 systems often have low efficiency. Here the authors fuse a Rad51 DNA-binding domain to create hyPE2 with improved editing efficiency.

Myungjae Song
Jung Min Lim
Hyongbum Henry Kim
ResearchOpen Access23 Sept 2021
Nature Communications

Volume: 12, P: 1-8
State of ex situ conservation of landrace groups of 25 major crops

By analysing the state of representation of traditional varieties of 25 major crops in ex situ repositories, this study demonstrates conservation progress made over more than a half-century and identifies the gaps remaining to be filled.

Julian Ramirez-Villegas
Colin K. Khoury
Cristian Zavala
ResearchOpen Access09 May 2022
Nature Plants

Volume: 8, P: 491-499
Correction: Corrigendum: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Joonseok Cho
Yujian Zhang
Naohiro Terada
Amendments and CorrectionsOpen Access18 Aug 2017
Nature Communications

P: 1-4
Fit analysis of 3D-printed versus thermoformed clear aligners for labial tooth movement using micro-CT: an in vitro study

Sun Young Lim
Sung-Hwan Choi
Jung-Yul Cha
ResearchOpen Access09 Feb 2026
Scientific Reports

Volume: 16, P: 1-11
UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy

p62/SQSTM1 acts as a key mediator in the selective autophagy of protein aggregates, or aggrephagy. Here the authors identify the prefoldin-like chaperone UXT as an autophagy adaptor of p62 dependent aggrephagy and show that ectopic UXT expression delays motor neuron degeneration in a Xenopus model.

Min Ji Yoon
Boyoon Choi
Chungho Kim
ResearchOpen Access29 Mar 2021
Nature Communications

Volume: 12, P: 1-16
Impact of the COVID-19 pandemic on mortality and loss to follow-up among patients with dementia receiving anti-dementia medications

Hyuk Sung Kwon
Wonjae Sung
Hojin Choi
ResearchOpen Access05 Apr 2024
Scientific Reports

Volume: 14, P: 1-7
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention

Nonalcoholic steatohepatitis (NASH) is a devastating type of liver disease that is caused by hepatocellular death which triggers liver inflammation and fibrosis. Here, the authors show that MAP kinase phosphatase-1 promotes hepatocellular death thus, driving the development of NASH.

Bin Qiu
Ahmed Lawan
Anton M. Bennett
ResearchOpen Access05 Sept 2023
Nature Communications

Volume: 14, P: 1-19
mTORC1 mediates fiber type-specific regulation of protein synthesis and muscle size during denervation

Jae-Sung You
Kookjoo Kim
Troy A. Hornberger
ResearchOpen Access12 Apr 2021
Cell Death Discovery

Volume: 7, P: 1-7
Shear bond strength of zirconia orthodontic brackets depending on surface pretreatment of bonding base

Hyojin Kim
Hai-Van Giap
Kee-Joon Lee
ResearchOpen Access03 Nov 2025
Scientific Reports

Volume: 15, P: 1-12
Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM

Gap junction intercellular channels (GJIChs) facilitate direct communication between adjacent cells. Here, authors provide high-resolution information on dynamic structural changes in Cx43 GJICh that are necessary to understand the gating mechanism.

Hyuk-Joon Lee
Hyung Jin Cha
Jae-Sung Woo
ResearchOpen Access18 Feb 2023
Nature Communications

Volume: 14, P: 1-18
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease

Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide, and previous work has shown it is upregulated in models of Alzheimer’s disease. Here the authors demonstrate in a mouse model of Alzheimer’s disease that antibody-based immunotherapy targeting plasma ASM resulted in attenuated neuropathological features by suppressing pathogenic Th17 cells.

Byung Jo Choi
Min Hee Park
Jae-sung Bae
ResearchOpen Access24 Mar 2023
Nature Communications

Volume: 14, P: 1-17
Voltage-driven gigahertz frequency tuning of spin Hall nano-oscillators

Spin-hall nano-oscillators are a variation on spin-torque nano-oscillators, where the spin-Hall effect is used to drive oscillations, however past examples have had limited frequency tunability. Here, Choi et al demonstrate spin-hall oscillators with wide voltage controlled frequency tunability.

Jong-Guk Choi
Jaehyeon Park
Byong-Guk Park
ResearchOpen Access30 Jun 2022
Nature Communications

Volume: 13, P: 1-8
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease

Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads to increased secretion of SPMs from neurons in the context of Alzheimer’s disease models.

Ju Youn Lee
Seung Hoon Han
Jae-sung Bae
ResearchOpen Access12 May 2020
Nature Communications

Volume: 11, P: 1-19
Al atomistic surface modulation on colloidal gradient quantum dots for high-brightness and stable light-emitting devices

Jae-Sung Lee
Byoung-Ho Kang
Shin-Won Kang
ResearchOpen Access23 Apr 2019
Scientific Reports

Volume: 9, P: 1-9
Effects of knee osteoarthritis severity on inter-joint coordination and gait variability as measured by hip-knee cyclograms

Jae Hyeon Park
Hyojin Lee
Seong Ho Jang
ResearchOpen Access19 Jan 2021
Scientific Reports

Volume: 11, P: 1-8
Kidney Dysfunction Impact on White Matter Hyperintensity Volume in Neurologically Healthy Adults

Sang Hyuck Kim
Jae Moon Yun
Jin-Ho Park
ResearchOpen Access13 Jun 2019
Scientific Reports

Volume: 9, P: 1-7
Novel anti-biofouling light-curable fluoride varnish containing 2-methacryloyloxyethyl phosphorylcholine to prevent enamel demineralization

Jae-Sung Kwon
Myung-Jin Lee
Sung-Hwan Choi
ResearchOpen Access05 Feb 2019
Scientific Reports

Volume: 9, P: 1-9
Barium Titanate Nanoparticles Sensitise Treatment-Resistant Breast Cancer Cells to the Antitumor Action of Tumour-Treating Fields

Yi Na Yoon
Dae-Sik Lee
Jae-Sung Kim
ResearchOpen Access13 Feb 2020
Scientific Reports

Volume: 10, P: 1-9
Prevention of quality decline and delivery of siRNA using exogenous TCTP translocation across the zona pellucida in mouse oocytes

Hyuk-Joon Jeon
Guang-Yu Bai
Jeong Su Oh
ResearchOpen Access11 Dec 2019
Scientific Reports

Volume: 9, P: 1-8
Liver injury in a preclinical model of short bowel syndrome is associated with impaired autophagy

Daniel M. Alligood
Alex Park
Brad W. Warner
ResearchOpen Access08 Dec 2025
Scientific Reports

Volume: 16, P: 1-13
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

Sphingosine kinase (SphK) converts sphingosine into lipids, and is implicated in inflammation. Here the authors show that SphK1 functions as an acetyltransferase, regulates microglial phagocytosis and is reduced in a model of Alzheimer’s Disease, such that its restoration ameliorates pathology

Ju Youn Lee
Seung Hoon Han
Hee Kyung Jin
ResearchOpen Access16 Apr 2018
Nature Communications

Volume: 9, P: 1-14
Impact of toothbrushing on aesthetic and mechanical properties of hydrophilic antibacterial coating materials for orthodontic clear retainers

Young-Eun Oh
Hyung-Seog Yu
Jung-Yul Cha
ResearchOpen Access24 Nov 2025
Scientific Reports

Volume: 15, P: 1-10
Deep learning algorithm for predicting rapid progression of abdominal aortic aneurysm by integrating CT images and clinical features

Se Jin Oh
Jae-ik Shin
Jae Woong Choi
ResearchOpen Access03 Nov 2025
Scientific Reports

Volume: 15, P: 1-14
Whitening efficacy and enamel properties of 30% hydrogen peroxide solution incorporated with strontium-containing Fluorapatite

Ji-Yeon Hong
Eo-Jin Kang
Jae-Sung Kwon
ResearchOpen Access06 Oct 2025
Scientific Reports

Volume: 15, P: 1-9
Effects of aging on the physicomechanical, antimicrobial, and cytotoxicity properties of flowable composite resin with strontium-modified phosphate-based glass

Seo-Hyun Kim
Hye-Bin Go
Jae-Sung Kwon
ResearchOpen Access04 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Cerium doping of 45S5 bioactive glass improves redox potential and cellular bioactivity

Jeong-Hyun Ryu
Tae-Yun Kang
Min-Ho Hong
ResearchOpen Access09 Jul 2024
Scientific Reports

Volume: 14, P: 1-15
Genetic and imaging features of CADASIL patients with acute ischemic stroke

Jae Young Park
Jeong Yun Song
Bum Joon Kim
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-9
Novel two-stage expansion of Streptococcus mutans biofilm supports EPS-targeted prevention strategies for early childhood caries

Jeongmi Moon
Kyoungjin Seo
Jae-Sung Kwon
ResearchOpen Access24 Apr 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-12
Delineation of three-dimensional tumor margins based on normalized absolute difference mapping via volumetric optical coherence tomography

Jae-Sung Park
Taeil Yoon
Tae Joong Eom
ResearchOpen Access05 Apr 2024
Scientific Reports

Volume: 14, P: 1-10
Relationship between disproportionately enlarged subarachnoid-space hydrocephalus and white matter tract integrity in normal pressure hydrocephalus

Sunju Lee
Jae-Sung Lim
Jae-Hong Lee
ResearchOpen Access04 Dec 2023
Scientific Reports

Volume: 13, P: 1-11
Zinc-modified phosphate-based glass micro-filler improves Candida albicans resistance of auto-polymerized acrylic resin without altering mechanical performance

Myung-Jin Lee
Min-Ji Kim
Sung-Hwan Choi
ResearchOpen Access14 Nov 2022
Scientific Reports

Volume: 12, P: 1-10
Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis

Ye-Ram Kim
Jae-Sung Kim
Chul-Su Yang
ResearchOpen Access12 Mar 2020
Scientific Reports

Volume: 10, P: 1-15
Antibacterial properties of mesoporous silica coated with cerium oxide nanoparticles in dental resin composite

Sung-Yun Byun
A. Ruem Han
Jae-Sung Kwon
ResearchOpen Access03 Aug 2024
Scientific Reports

Volume: 14, P: 1-11
Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia

Daria Chestnykh
Christiane Mühle
Christian P. Müller
ResearchOpen Access17 Jan 2025
Molecular Psychiatry

Volume: 30, P: 2891-2906
Potential therapeutic target for aging and age-related neurodegenerative diseases: the role of acid sphingomyelinase

Min Hee Park
Hee Kyung Jin
Jae-sung Bae
ReviewsOpen Access13 Mar 2020
Experimental & Molecular Medicine

Volume: 52, P: 380-389
Impact on capsule formation for three different types of implant surface tomography

Hyeon Jun Jeon
MyeongJae Kang
Jung Dug Yang
ResearchOpen Access08 Aug 2022
Scientific Reports

Volume: 12, P: 1-11
Evaluation of the effects of temperature and centrifugation time on elimination of uncured resin from 3D-printed dental aligners

Ji-Eun Kim
Utkarsh Mangal
Sung-Hwan Choi
ResearchOpen Access02 Jul 2024
Scientific Reports

Volume: 14, P: 1-11
Development of statistical auto-segmentation method for diffusion restriction gray matter lesions in patients with newly diagnosed sporadic Creutzfeldt–Jakob disease

Hwon Heo
Ho Young Park
Sang Joon Kim
ResearchOpen Access20 Feb 2024
Scientific Reports

Volume: 14, P: 1-11
Mechanical properties and sustainable bacterial resistance effect of strontium-modified phosphate-based glass microfiller in dental composite resins

Hye-Bin Go
Myung-Jin Lee
Jae-Sung Kwon
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-11
Dimensional accuracy, mechanical property, and optical stability of zirconia orthodontic bracket according to yttria proportions

Changbum Park
Hai-Van Giap
Kee-Joon Lee
ResearchOpen Access21 Nov 2023
Scientific Reports

Volume: 13, P: 1-13

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