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Showing 1–21 of 21 results

Advanced filters: Author: Jessalyn M. Ubellacker Clear advanced filters

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance

After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B₂) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in cancer cells.

Vera Skafar
Izadora de Souza
José Pedro Friedmann Angeli
ResearchOpen Access13 Mar 2026
Nature Cell Biology

P: 1-11
Acidic niche sugar shield blocks ferroptosis

Tumour acidosis is known to drive metabolic adaptations in cancer cells, contributing to their survival and resistance to therapies. A study now identifies a chondroitin sulfate-enriched glycocalyx as a key feature of the acidic tumour microenvironment in glioblastoma that limits lipid uptake and protects cells against death by ferroptosis.

Mario Palma
Jessalyn M. Ubellacker
News & Views05 Mar 2026
Nature Cell Biology

Volume: 28, P: 390-391
Author Correction: Lymphatic collection and cell isolation from mouse models for multiomic profiling

Marie Sabatier
Ani Solanki
Jessalyn M. Ubellacker
Amendments and Corrections10 Feb 2025
Nature Protocols

P: 1
Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTENmRNA

Mohammad Ariful Islam
Yingjie Xu
Jinjun Shi
Amendments and Corrections05 Feb 2025
Nature Biomedical Engineering

Volume: 9, P: 284
Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

Mohammad Ariful Islam
Yingjie Xu
Jinjun Shi
Amendments and Corrections23 Nov 2018
Nature Biomedical Engineering

Volume: 2, P: 968
Prospects for ferroptosis therapies in cancer

Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of cell death, as well as potential translational applications in cancer therapeutics.

Jessalyn M. Ubellacker
Scott J. Dixon
Reviews18 Aug 2025
Nature Cancer

Volume: 6, P: 1326-1336
Lymph node environment drives FSP1 targetability in metastasizing melanoma

Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

Mario Palma
Milena Chaufan
Jessalyn M. Ubellacker
ResearchOpen Access05 Nov 2025
Nature

Volume: 649, P: 477-486
Activation of lysosomal iron triggers ferroptosis in cancer

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

Tatiana Cañeque
Leeroy Baron
Raphaël Rodriguez
ResearchOpen Access07 May 2025
Nature

Volume: 642, P: 492-500
Targeting FSP1 to induce ferroptosis in chromophobe renal cell carcinoma

Samer Salem
Tiegang Han
Elizabeth P. Henske
Research06 Sept 2025
Oncogene

Volume: 44, P: 4075-4086
Leptin receptor⁺ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor

Gao et al. report that leptin receptor⁺ stromal cells sustain nerves in the bone marrow by producing nerve growth factor. After myeloablation, nerves promote marrow regeneration by increasing the production of multiple growth factors by leptin receptor⁺ cells.

Xiang Gao
Malea M. Murphy
Sean J. Morrison
ResearchOpen Access27 Nov 2023
Nature Cell Biology

Volume: 25, P: 1746-1757
Multi-omics microsampling for the profiling of lifestyle-associated changes in health

Dense multi-omics microsampling for the frequent capture and analysis of thousands of molecules in blood alongside physiological information from wearables facilitates the profiling of lifestyle-associated changes in an individual’s health.

Xiaotao Shen
Ryan Kellogg
Michael P. Snyder
ResearchOpen Access19 Jan 2023
Nature Biomedical Engineering

Volume: 8, P: 11-29
Dynamic lipidome alterations associated with human health, disease and ageing

Longitudinal deep lipidome profiling reveals >800 lipid species, many of which are associated with health-to-disease transitions in diabetes, ageing and inflammation.

Daniel Hornburg
Si Wu
Michael P. Snyder
ResearchOpen Access11 Sept 2023
Nature Metabolism

Volume: 5, P: 1578-1594
Metabolic heterogeneity confers differences in melanoma metastatic potential

Differences in MCT1 function among melanoma cells confer differences in oxidative stress resistance and metastatic potential.

Alpaslan Tasdogan
Brandon Faubert
Sean J. Morrison
Research18 Dec 2019
Nature

Volume: 577, P: 115-120
A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis

A peri-arteriolar niche in the bone marrow for osteogenesis and lymphopoiesis is maintained by mechanical stimulation and is depleted during ageing.

Bo Shen
Alpaslan Tasdogan
Sean J. Morrison
Research24 Feb 2021
Nature

Volume: 591, P: 438-444
Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

The reintroduction of PTEN mRNA into PTEN-null prostate cancer cells via encapsulation in polymer–lipid nanoparticles delivered systemically leads to significant inhibition of tumour growth in mouse models of prostate cancer.

Mohammad Ariful Islam
Yingjie Xu
Jinjun Shi
Research17 Sept 2018
Nature Biomedical Engineering

Volume: 2, P: 850-864
Lymph protects metastasizing melanoma cells from ferroptosis

Melanoma cells undergo less oxidative stress and less ferroptosis in lymph than in blood, owing to higher levels of oleic acid in lymph, and thus exposure to the lymphatic environment increases subsequent metastasis through blood.

Jessalyn M. Ubellacker
Alpaslan Tasdogan
Sean J. Morrison
Research19 Aug 2020
Nature

Volume: 585, P: 113-118
IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization

Castaño et al. show that primary breast tumours drive an IL-1β -mediated inflammatory response that inhibits cellular plasticity and metastatic colonization of metastasis-initiating cells.

Zafira Castaño
Beatriz P. San Juan
Sandra S. McAllister
Research27 Aug 2018
Nature Cell Biology

Volume: 20, P: 1084-1097
Lymphatic collection and cell isolation from mouse models for multiomic profiling

An approach to collect lymph drained from the primary tumor in mice enables the downstream characterization of the samples using metabolomics, lipidomics and flow cytometry.

Marie Sabatier
Ani Solanki
Jessalyn M. Ubellacker
Protocols08 Jan 2025
Nature Protocols

Volume: 20, P: 884-901
CDK4/6 inhibition triggers anti-tumour immunity

Mouse models of breast carcinoma and other solid tumours show that selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors not only induce tumour cell cycle arrest but also promote anti-tumour immunity.

Shom Goel
Molly J. DeCristo
Jean J. Zhao
Research16 Aug 2017
Nature

Volume: 548, P: 471-475
Deep imaging of LepR⁺ stromal cells in optically cleared murine bone hemisections

Yuehan Ni
Jiamiao Wu
Bo Shen
ResearchOpen Access13 Jan 2025
Bone Research

Volume: 13, P: 1-17
Lipidomics and metabolomics as potential biomarkers for breast cancer progression

Alanis Carmona
Samir Mitri
Jessalyn M. Ubellacker
ReviewsOpen Access02 Sept 2024
npj Metabolic Health and Disease

Volume: 2, P: 1-9