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Thymine DNA glycosylase (TDG) was identified as a synthetic-lethal target in p53-deficient cancers through alterations in double-stranded RNA accumulation. A covalent small-molecule inhibitor of TDG exhibited potent efficacy against p53-deficient tumors.

This study reveals how Tau pathology in spinal neurons contributes to early tactile deficits in Alzheimer’s disease, linking sensory dysfunction to cognitive decline. It highlights potential peripheral biomarkers and new therapeutic targets beyond the brain.

The mechanism of superconductivity in layered kagome metals remains unclear, however its coexistence with charge order suggests exotic interpretations. Here the authors study the vortex lattice in the superconducting state of Ta-doped CsV₃Sb₅ with suppressed charge order, suggesting conventional pairing.

In the kagome superconductor CsV₃Sb₅, superconductivity is intertwined with an unconventional charge density wave and the pairing symmetry remains unclear due to the absence of direct superconducting gap measurements. Here, the authors use laser-based ultra-high-resolution angle-resolved photoemission spectroscopy to reveal a highly anisotropic superconducting gap on the Fermi surface originating from the 3d-orbital electrons of the vanadium sublattice, providing insights into the physics of intertwined orders in kagome superconductors.

The authors show that hot-pressing markedly improves high-power performance. In the hot-pressing process, the combined effect of applied pressure and sintering aids reduces the sintering temperature, which not only minimizes lead volatilization but also promotes densification.

The synthesis of ionic olefin linked threedimensional covalent organic frameworks (3D COFs) is challenging because of the difficulties in forming stable carbon-carbon double bonds. Here, the authors report a general synthesis of an ionic sp² carbon linked COFs and demonstrate selective capture of ReO₄⁻ ions.

The understanding of kagome bands, which are characterized by Dirac-like bands capped by a flat band, remains largely elusive. Here, Liu et al. report the observation of a flat band and Dirac bands as ideal features of kagome bands in CoSn, revealing orbital-selective character.

This study shows how a dirigent protein and an aldo-keto reductase derail the gossypol pathway in cotton, producing hemigossypolone and heliocides in green organs and enhancing plant defense, revealing insights into plant specialized metabolism.

A Z-type ZnO@COF heterostructure composite with excellent piezoelectric properties was synthesized for the piezocatalytic uranium extraction from seawater, helping to realize efficient uranium extraction by wave energy

Experimental systems in which non-trivial topology is driven by spontaneous symmetry breaking are rare. Now, topological gaps resulting from two excitonic condensates have been demonstrated in a three-dimensional material.

The authors observe spectroscopic signature of obstructed surface states on the (0001) plane of SrIn₂P₂. Due to structural reconstruction, the surface state undergoes an adiabatic evolution and split into two branches, the upper of which being spatially localized with unusual negative differential conductance.

Using normal and Josephson scanning tunnelling microscopy, chiral kagome superconductivity modulations with corresponding residual Fermi arcs are detected in KV₃Sb₅ and CsV₃Sb₅.

The symmetry and mechanism underlying unconventional charge orders in Kagome materials are under debate. Here, the authors uncover a longitudinal and helicity-dependent photocurrent in KV₃Sb₅ that indicates broken symmetries and intrinsic chirality.

A ferromagnetic tunnelling contact enables electrically controlled valley polarization in monolayer WSe₂.

Chemicals of emerging concern threaten health and the environment, necessitating effective water treatment. This study clarifies the water-health-environment nexus and suggests approaches to align drinking water with health and sustainability goals.

The pairing mechanism in kagome superconductors is still not fully understood. Now, CsV₃Sb₅, which belongs to this family, is shown to have orbital-selective pairing with two distinct superconducting domes that are not separated by any phase boundary.

Dysregulated prefrontal control over amygdala has been implicated in the etiology of stress-related psychiatric disorders. Here, the authors show that the dysregulation preferentially occurs in amygdala neurons that are mono- but not bi-directionally connected with dorsomedial prefrontal cortex.

Kagome materials have become a popular platform to investigate a range of competing quantum phases, such as the interplay between superconductivity and charge density waves (CDW). Here, the authors use x-ray diffraction, scanning tunneling microscopy and resonant elastic x-ray scattering to investigate the evolution of CDW ordering as a function of temperature in canted antiferromagnetic kagome FeGe. They find for post-annealed samples that the long-range CDW orders persist even as the structural modulations are suppressed although observations are highly dependent on the sample growth condition.

Treatment of patients with HER2-mutant non-small-cell lung cancer with the pan-HER inhibitor pyrotinib in a phase 2 trial or compassionate use showed a favorable objective response rate, whereas patients treated in parallel by physician’s choice in a real-world study did not.

The conversion of CO₂ to valuable chemicals is still challenged by catalyst developments. Herein, the authors found that GaN is an efficient catalyst for selective CO₂ hydrogenation to dimethyl ether as the primary product, in contrast to the traditional methanol-intermediate route over hybrid catalysts.

Achalasia is a rare motility disorder of the esophagus resulting from abnormal immune responses, but the immunologic mechanism is unclear. Here the authors use scRNA-seq of PBMC and esophageal lower sphincter tissue and find C1QC⁺ macrophages and tissue-resident memory T cells with expanded compositions and altered transcriptional profiles in achalasia.

An unconventional chiral charge order is observed in a kagome superconductor by scanning tunnelling microscopy. This charge order has unusual magnetic tunability and intertwines with electronic topology.

Topological boundary modes within charge-ordered states have not yet been observed experimentally. Now an in-gap boundary mode, stemming solely from the charge order, is visualized in the topological material Ta₂Se₈I.

The mechanism of charge density wave order in V-based kagome metals has been debated. Here the authors use a range of experimental techniques combined with ab initio calculations to study the electronic structure and phonon modes of ScV₆Sn₆, revealing the dominant role of strong electron-phonon coupling.

Topologically protected hinge modes could be important for developing quantum devices, but electronic transport through those states has not been demonstrated. Now quantum transport has been shown in gapless topological hinge states.

The authors provide a comprehensive characterization of the human antibody response to a licensed hepatitis E virus (HEV) vaccine, Hecolin, in four individuals over the course of six months post vaccination. They demonstrate diverse patterns of antibody response underlying the vaccine protection.

Direct imaging and tuning of flat band localization in kagome materials remains a challenge. Here, scanning tunneling microscopy and photoemission spectroscopy are used to study FeSn, revealing real-space localization and magnetic tuning of the flat band state within the Fe₃Sn kagome lattice layer.

Analysis of the antiferromagnetic ordered phase of kagome lattice FeGe suggests that charge density wave is the result of a combination of electronic-correlations-driven antiferromagnetic order and instability driven by van Hove singularities.

Strong correlations between electrons in topological surface states drive the formation of surface van Hove singularities. These may be linked to charge density waves in the surface states.

The authors use scanning tunnelling microscopy and muon spin resonance to demonstrate time-reversal symmetry-breaking superconductivity in Cs(V, Ta)₃Sb₅. The Cooper pairing in this state exhibits magnetism and is modulated by it.

The search for magnetic Weyl fermion remains a challenge. Here, the authors report angle-resolved photoemission spectroscopy and magnetotransport measurements resolving the topological properties of Weyl fermion quasiparticles in magnetic non-centrosymmetric crystal PrAlGe.

Zeolite Cu(I)Y is attractive for adsorptive removal of sulfur compounds from fuel, however practical application is limited by instability of Cu(I). Here the authors use a coating to achieve superhydrophobicity in the zeolite, leading to improved Cu(I) stability against oxidation and thiophene removal.

The topological magnet Fe₃Sn₂ exhibits a giant nematic energy shift of a many-body electronic state, demonstrating anisotropic spin–orbit tunability.