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Cancer cells could sense the availability of glucose to coordinate macromolecular synthetic processes. Here the authors find that glucose-activated adenylosuccinate lyase (ADSL) possesses a moonlighting function of promoting protein succination, thereby upregulating lipogenesis in hepatocellular carcinoma cells.

Bilayer CrTe₂ films grown via molecular beam epitaxy are found to host room-temperature multiferroicity and strong magnetoelectric coupling.

Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.

Ming et. al. reports a memristor with an intrinsic ionic gradient that enables stable second-order dynamics and physically modulated learning rates. The device supports stable, energy-efficient continual reinforcement learning and adaptive decision-making.

This study shows that the El Niño/Southern Oscillation (ENSO) drives sea surface salinity (SSS) variability in the China Seas through coupled freshwater and oceanic processes, influencing regional fisheries. Under a warming climate, projected intensification of ENSO will amplify SSS heterogeneity.

The miniaturization of spectrometers to a submillimeter-scale footprint opens opportunities for applications in hyperspectral imaging and lab-on-a-chip systems. Here, the authors report a high-performance single-pixel photodetector spectrometer based on the III-V semiconductor p-graded-n junction, featuring a voltage-tunable optical response.

Patient-derived glioma cell (PDGC) cultures have been poorly characterized on a molecular level. Here, the authors analyze 50 PDGC lines from glioblastoma patients using multi-omics and drug screening; find molecular subtypes that are associated with drug response and prognosis, as well as a MYC/MYCN-amplification associated with serum-free culture.

The mechanical properties of inorganic solid electrolytes for Li batteries are typically characterised by a high Young’s modulus above 15 GPa and hardness above 1 GPa. Here, authors develop a cost-effective and mechanically compliant inorganic solid electrolyte, with reduced Young’s modulus and hardness of 1.41 and 0.22 GPa, respectively, for practical all-solid-state Li batteries.

Multi-axis atropisomers are common, but techniques for structural elucidation are limited. Here, the authors report a correlation between molecular dynamics and electronic through-space conjugation (TSC), along with absolute separation of the syn and anti conformers.

Current pulses of 10⁵ A cm⁻² can control the orientation of 100-nm-wide stripe domains in La_0.67Sr_0.33MnO₃ and spin waves of 10 GHz can propagate along these domains with a group velocity of 2.6 km s⁻¹.

The chemoselective hydrogenation of molecules containing multiple reducible groups using molecular hydrogen presents inherent challenges. Here, the authors synthesize a homoleptic gold nanocluster that demonstrates exceptional catalytic selectivity, activity, and yield for the hydrogenation of 4-nitroacetophenone in water under mild conditions.

This work establishes a unified ultra-wideband optical diffractive model that achieves full-band mode multiplexing across O to U telecommunication wavelengths, paving the way for ultra-high-capacity optical communications.

Tuning the interfacial structure of silver nanoclusters via steric hindrance modulates their photoluminescence. Locking the ligand shell endows the clusters with room-temperature photoluminescence, thereby enabling atomic-level design of optical devices.

Environmental transmission electron microscopy reveals distinct atomistic pathways for the reduction of NiO to metallic nickel by CO and H₂, with H₂ more effective in transforming the entire bulk material.

Bridgehead carbon benzofused-bridged ring systems have previously not been accessible via synthetic approaches. Here, the authors report a formal type-II [4 + 4] annulation approach that provides fully sp₂-carbon embedded anti-Bredt bicyclo[5.3.1] skeletons through the Rh-catalyzed C1–C8 activation of benzocyclobutenones and their coupling with pedant dienamides.

Fouling of solid surfaces is a problem when designing microchannel systems for applications such as bioassays and drug delivery. Here Hou et al. propose a way to overcome this issue by controlling fluid flow by means of an immiscible functional liquid partly infiltrated in a porous solid matrix.

Fabricating complex nanodevices requires joining techniques such as welding, common for metals but still out of reach for ceramics. Here the authors use MgO as a solder in a transmission electron microscope with a CO₂ atmosphere to weld ceramic nanowires, and show their novel technique can also weld bulk ceramics.

The authors uncovered the electric-field-induced deformation mechanisms of nanostructured electrodes, elucidating the interaction between the electric field and the electrode material at the atomic scale.

Here, authors use Cryo-FIB and Cryo-TEM to reveal the atomic structures of the sulfide electrolyte/Si electrode interfaces, showing that the continuous lithium-ion consumption during interfacial reaction rather than interface impedance leads to capacity fade and battery failure.

Dong et al. achieve Sb₂(S,Se)₃ solar cells with 10.7% efficiency by increasing charge generation with a textured electrode and reducing charge recombination and transport loss with a conformal electron-selective layer.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Clusteroluminescence from nonconjugated luminogens relies on noncovalent through-space conjugation of electrons resulting in low luminescent efficiency and broad emission. Here the authors construct several nonconjugated luminogens to reveal the structure property relationship and demonstrate narrowband clusteroluminescence with high emission efficiency.

The mechanisms of the natural control of hepatitis B virus infection remain obscured. Here, the authors reveal that matrix stiffness influences HBV replication via YAP-mediated mechanosignaling, uncovering a novel non-cytolytic mechanism for clearing viral infections in the liver.

A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses in temporary cardiac pacing.

This study reveals the genetic basis of Benzylisoquinoline alkaloids (BIAs) biosynthesis in magnoliids, and further illustrates that preferentially retained ancient gene duplicates enabled BIA production in early-diverging eudicots and magnoliids.

A micronuclear battery is built based on an autoluminescent americium–terbium compound that couples radioisotopes with energy transducers at the molecular level, resulting in an 8,000-fold enhancement in energy conversion efficiency.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

This work presents a fully implantable wireless optogenetic device that delivers spatiotemporally patterned cortical stimulation through the skull and generates artificial perception in mice.

It is extremely difficult to separate tritium from radioactively contaminated water. Here the authors introduce catalytic hydrogen isotope exchange to water distillation, realizing excellent detritiation performance.

Long-distance magnon transport is highly desired for magnonics. Here, the authors demonstrate a millimetre-long magnon decay length in multiferroic heterostructures, which is attributed to magnon-polarons induced by the magnetoelastic coupling.

A thermo-assisted spin-coating process followed by packaging is used to fabricate sodium films that are stable for several months, enabling the realization of plasmonic devices with state-of-the-art performance at near-infrared wavelengths.

The authors identified a broadly applicable scaling relationship between field emission characteristics and the ratio of apex radius to gap length, and proposed a modified field emission equation suitable for nanoscale applications.

Intercropping has the potential to improve plant nutrition and crop yield. Here, the authors intercrop peanut and maize and show that Pseudomonas secreted siderophore pyoverdine play an important role in plant iron nutrition.

Weakly space-confined, large-grained crystals of all-inorganic perovskite were used to fabricate light-emitting diodes with a high external quantum efficiency and operational stability.

Low-dimensional materials containing defects such as twin boundaries are known to fail well below their theoretical strength due to surface imperfections. Here, Wang et al. observe strengths close to the ideal limit in gold nanowires with angstrom scale twins, where homogeneous dislocation nucleation controls deformation.

The electrode/electrolyte interface plays a critical role in a Li-ion battery. Here the authors report that Al doping can tailor the interfacial reactions to lead to enhanced structural stability and cyclability of cathode. Al dopants form not only lattice solid solution but also Al₂O₃ islands on the surface.

The genome of the tropical blue-petal water lily Nymphaea colorata and the transcriptomes from 19 other Nymphaeales species provide insights into the early evolution of angiosperms.

Arabidopsis thaliana mutants expressing Lhcb8, a stress-induced paralog to Lhcb4 reveal its role in tuning the light-harvesting system of Photosystem II under excess light and maintaining high quantum efficiency.

The genetic basis of prolactinomas remains poorly understood. Here, the authors find a recurrent hotspot somatic mutation in the splicing factor 3 subunit B1 (SF3B1^R625H) in prolactinomas, and show that this mutation causes aberrant splicing of ESRRG mRNA leading to up-regulation of prolactin.

Molecular interactions are of great importance in materials science. Here, the authors use the confinement effect and low-dose imaging to reveal the confined molecules and evaluate the strength of host-guest interactions in different material systems.

While strain engineering via support modification is a powerful strategy to tune catalytic properties, it is complex to control for immobilized molecular complexes. Now the curvature of carbon nanotubes is leveraged to induce strain to metal phthalocyanine complexes and boost their electrocatalytic activity

Temporal causation models perform poorly in causal inference for variables with limited temporal variations. This paper establishes a causal inference model, which can reveal the nonlinear complex casual associations based on cross-sectional Earth System data.

Steam treatment transforms inactive Pd₁/CeO₂ catalyst into a highly reactive one by forming a Ce₂O₃-Pd nanoparticle interface. This domain interface is created by the coordinated migration of Ce and Pd atoms on the atom trapped Pd₁/CeO₂.

The chemical compositions of young lava flows on the Moon have implications for late volcanism. Here, the authors present mineral distribution data from the Chang′e-3 Yutu rover in the northern Imbrium mare region, reporting unique compositional characteristics of a previously unsampled basalt type.

Despite initial treatment with surgical resection, glioblastoma multiforme (GBM) frequently recurs. Here the authors report the design of an immunostimulatory autolysing Salmonella based-nanocapsule delivery system, promoting anti-tumor immune responses and preventing postoperative relapse in preclinical GBM models.

High yields of methanol are difficult to achieve with direct oxidation of methane to methanol. Here the authors report a high methanol space-time yield which is attributed to the confinement effect of 6-membered ring voids and the isolated Cu-OH single sites in SSZ−13 zeolite.