Search

SLCO4C1 is known for regulating kidney diseases. This study showed SLCO4C1 regulates hepatic cAMP uptake to suppress lipogenesis in MASLD. Targeting this pathway by FGF21 or forskolin suppressed lipogenesis.

A sequential deposition method combined with a multifunctional organic additive enables sky-blue all-thermally evaporated perovskite light-emitting diodes with a peak external quantum efficiency of 20.15%, as well as their integration into an active-matrix display prototype.

In the phase III NAPOLI-3 trial, first-line treatment with NALIRIFOX was associated with improved overall survival compared to gemcitabine plus nab-paclitaxel in patients with metastatic pancreatic adenocarcinoma. Here the authors report the results of a randomized phase II trial comparing the two regimens, NALIRIFOX versus Gemcitabine plus Nab-Paclitaxel, in Chinese patients.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Large language models are starting to be used in safety-critical tasks such as controlling robots. Zhou et al. present LabSafety Bench, a benchmark evaluating the ability of large language models to identify hazards and assess laboratory risks.

A study presents the results of surveillance for SARS-CoV-2 in animal and environmental samples from a market linked to early human cases of coronavirus disease 2019.

New epidemiological data from the American Cancer Society indicate a continued decline in overall cancer mortality in the USA but also reveal alarming countertrends. Rising advanced-stage presentation of prostate cancer, an accelerating incidence of early-onset colorectal cancer, and widening disparities in uterine and lung cancer outcomes underscore that the next frontier in oncology is equitable delivery, not just biological discovery.

Partial oxidation of methane to value-added C₁ products remains challenging due to the favorable formation of fully-oxidized CO₂. Here, the authors show supported B₂O₃ catalysts with tri-coordinated BO₃ units as the active site are highly selective in oxidizing methane to HCHO and CO.

Wu et al. developed SkySense++, a multi-modal remote sensing foundation model pretrained on 27 million multi-modal images, which achieved robust generalization and few-shot capabilities across several Earth observation tasks and domains, including agriculture and disaster management.

The combination of anti-PD-1 treatment with cisplatin and 5-fluorouracil in patients with previously untreated, PD-L1-positive esophageal squamous cell carcinoma improved progression-free survival and overall survival.

The DAWN study is a phase 3 clinical trial that demonstrates effective glycemic control of dorzagliatin as an add-on therapy to metfomin in patients with type 2 diabetes.

In a prespecified interim analysis of the phase 3 trial GEMSTONE-304, anti-PD-L1 with chemotherapy versus chemotherapy alone led to significantly prolonged progression-free survival and overall survival of patients with unresectable, locally advanced, recurrent or metastatic esophageal squamous cell carcinoma.

Integrator–PP2A (INTAC) is essential for promoting premature termination of paused RNA polymerase II. Here, the authors identify DSS1, a 70-residue protein present in diverse complexes, as an integral INTAC subunit that maintains its structural integrity and supports its transcriptional functions.

Fan, Shang, Song, Chen et al. identify the Integrator–PP2A complex (INTAC) as a key regulator of cancer cell sensitivity to BET inhibitors through directly interacting with the RACK7–KDM5 complex to orchestrate epigenetic silencing in a catalytic-independent manner.

UHRF1 is involved in the maintenance of DNA methylation, but the regulatory mechanism of this epigenetic regulator is unclear. Here, the authors show that it has a closed conformation and are able to make conclusions about the mechanism of recognition of epigenetic marks.

Steam treatment transforms inactive Pd₁/CeO₂ catalyst into a highly reactive one by forming a Ce₂O₃-Pd nanoparticle interface. This domain interface is created by the coordinated migration of Ce and Pd atoms on the atom trapped Pd₁/CeO₂.

Patients with advanced esophageal cancer have poor prognosis and limited treatment options. This randomized, phase II trial compares the efficacy and safety of the anti-PD-1 antibody sintilimab versus chemotherapy in Chinese patients with esophageal squamous cell carcinoma after first-line therapy

Cryo-electron microscopy is widely employed in structural biology and uses phase contrast imaging. Here, the authors employ electron ptychography, a quantitative phase retrieval method for high-contrast, low-dose phase imaging of cryo-state rotavirus and immature HIV-1 virus-like particles, and show that electron ptychography is more efficient for phase recovery than conventional phase contrast imaging.

High yields of methanol are difficult to achieve with direct oxidation of methane to methanol. Here the authors report a high methanol space-time yield which is attributed to the confinement effect of 6-membered ring voids and the isolated Cu-OH single sites in SSZ−13 zeolite.

SOSS–INTAC stimulates promoter-proximal termination of transcription and attenuates R-loops associated with paused RNA polymerase II to prevent R-loop-induced genome instability.

This study reveals the role of the Rpd3S complex in genomic integrity, highlighting how its asymmetrical structure influences interaction with transcribed nucleosomes and elongating RNA polymerase II.

Spontaneous migration of H-atoms from metal particles to a nonreducible oxide support is generally limited by thermodynamics. Here, small oxygenate molecules are found to act as effective H-carriers to promote this process and lead to much improved hydrodeoxygenation rates on Pt-Fe/SiO₂ catalysts.

A comprehensive transcriptomic survey of the pig could enable mechanistic understanding of tissue specialization and accelerate its use as a biomedical model. Here the authors characterize four distinct transcript types in 31 adult pig tissues to dissect their distinct structural and transcriptional features and uncover transcriptomic variability related to tissue physiology.

The nature of metal–ligand interactions remains unclear in coordination chemistry. Hao et al. address this question using in situelectrochemically controlled atomic force microscopy, which can monitor and modulate the coordinative bonding in a transition metal complex at a molecular level.

The independently evolved extreme holoparasites Balanophora and Sapria display convergent characteristics of genome modifications, including gene loss in particular pathways, reduction of multigene families and relaxed selection pressures.

An initial characterization of the receptor-binding properties of the novel avian influenza A (H7N9) shows that the virus has acquired the ability to bind human receptors while retaining the ability to bind avian receptors; the virus infects epithelial cells in the human lower respiratory tract and type II pneumocytes in the alveoli, and hypercytokinaemia was seen in infected patients.

In DNA demethylation, human TET proteins are evolutionarily tuned to be less reactive towards 5hmC and facilitate its generation as a potentially stable mark for regulatory functions.