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Radiopharmaceuticals engineered with click chemistry to selectively bind to tumour-specific proteins can be used to successfully target tumour cells, boosting the pharmacokinetics of radionuclide therapy and improving tumour regression.

Aging affects multiple organs and tracking these changes could improve our understanding of disease risk. Here, the authors show that metabolomics-based organ-specific aging clocks can predict future risk of cardiometabolic disease and mortality.

Imperatorin stimulates cardiomyocyte DNA repair and proliferation by enhancing the phosphorylation of TDP1 at serine 81 through facilitating the proximity-mediated interaction between TDP1 and DNA-PKcs.

A lipid-nanoparticle-based formulation incorporating engineered lipids containing a blood–brain-barrier-crossing moiety effectively delivers mRNA to neurons and astrocytes following systemic administration in mice.

In Bi₂O₂Se thin films, the local inversion-symmetry breaking in two sectors of the [Bi₂O₂]²⁺ layer yields opposite Rashba spin polarizations, which compensate each other and give rise to the hidden Rashba effect. Hence, the films exhibit only even-integer quantum Hall states, but there is no sign of odd-integer states.

Platinum nanoclusters comprising about ten atoms each made by reducing isolated platinum cations in CeO_x nests isolated on high-area silica are demonstrated. Two forms of platinum were reversibly interconverted by oxidation/reduction, remaining stably confined to the nests even under severe conditions, in H₂ at 600 °C and under atmospheric pressure.

Adipose stem cells are promising therapeutic agents in tissue regeneration. Here the authors develop a lipid nanoparticle/RNA engineering platform to enhance the protein production of these cells, which demonstrate superior healing efficacy in a mouse model of diabetic cutaneous wounds.

Reduction of nitroarenes in the presence of other reducible groups is challenging, as is simultaneously achieving high selectivity and activity. Here, the authors report supported single-atom and pseudo-single-atom platinum catalysts with excellent activity and high degrees of chemoselectivity.

Xu et al. report reconfigurable phototransistors based on MAPbI₃/Bi₂O₂Se heterostructure, with momentum conservation promotes hot carrier extraction and interlayer carrier transport. Heterotransistor array enables traffic light signal detection under dim light, assisted by YOLOv4 neural network.

Using a Cas13d-based nanosystem to knockdown lung protease cathepsin L, Cui et al. demonstrated that CRISPR–Cas system can be used to prevent and treat SARS-CoV-2 infection by targeting mRNA of host genes.

Nanometre-sized ‘nanoglue’ islands of CeO_x on high-surface-area SiO₂ are shown to suppress sintering and confine on average one Pt atom per island, leading to stable single-atom catalysts under oxidizing and reducing environments.

Core-shell catalysts can enhance activity while reducing the loading of expensive catalyst materials. Here, the authors report a palladium@platinum system in which the platinum shells evolve into a corrugated structure with compressive strains, with subsequent enhancement of oxygen reduction activity.

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

In this paper, the hepatitis C virus inhibitors Pibrentasvir and Ombitasvir are found to inhibit the SARS-CoV-2 exonuclease and are shown to have therapeutic potential when combined with SARS-CoV-2 polymerase inhibitors in viral cell cultures.

The issue that whether single-atom sites possess similar catalytic properties to the interfacial sites of nanocatalysts remains unresolved. Here, the authors demonstrate a large H₂O promotional effect on CO oxidation over Au single-atom sites due to their unique local atomic structure and electronic properties.

Defect-free integration of 2D materials onto semiconductor wafers is desired to implement heterogeneous electronic devices. Here, the authors report a method to transfer high-quality graphene on target wafers via gradient surface energy modulation, leading to improved structural and electronic properties.

Overcoming the immunosuppressive tumour microenvironment is a challenge. A strategy to close the cancer–immunity cycle has been reported by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy to promote tumour elimination and develop antitumour immunity.

The epitaxial synthesis of high-density, vertically aligned arrays of two-dimensional (2D) fin-oxide heterostructures is described, enabling the fabrication of 2D fin field-effect transistors with high electron mobility and desirable low-power specifications.

Gold catalysts have previously been reported for the epoxidation of alkenes with molecular oxygen. Here the authors show that, rather than the gold nanoparticles, the active species for this reaction are actually small, soluble gold species stabilized by the oxidised organic products.

Supported metal single-atom catalysts face challenges on both durability and practicality. Here, the authors demonstrate that a sustained 90% diesel oxidation conversion at ~160 ^oC is achieved by single-atom Pt on TiO₂ nanowire-array integrated catalytic converter.

Large-size single-crystal van der Waals layered Bi₂SeO₅ has been synthesized with a high dielectric constant and high breakdown field strength for two-dimensional electronics applications.

Copper on ceria is an excellent catalyst for the low-temperature water–gas shift reaction. Here the active sites are directly imaged by electron microscopy and probed with in situ spectroscopy, showing that the reaction proceeds via a cooperative mechanism whereby the Cu⁺ chemically adsorbs CO while an adjacent O_v–Ce³⁺ site dissociatively activates H₂O.

An important goal for the improvement of certain heterogeneous catalysts is to decrease the amount of platinum required while maintaining high catalytic activity. Now, the practical synthesis of a stable catalyst consisting of isolated single platinum atoms anchored onto iron oxide nanocrystallites has been developed that exhibits high activity for CO oxidation.

Claude-Taupin et al. show that ATG9A mediates protection against plasma membrane damage in diverse biological contexts through a mechanism involving IQGAP1 and ESCRTs.

It remains difficult to identify non-trivial band topology through electronic transport in narrow-gap topological materials. Here, the authors demonstrate that an inverted band leads to a four-fold splitting of non-zero Landau levels and an anomalous zero Landau level peak in the density of states of ZrTe₅, hence can serve as an indicator to explore non-trivial topology.

The study by Fu and colleagues presents a ferritin-adaptor platform for vaccine development, featuring a rabies virus vaccine candidate that enhances antigen stability and provides potent, durable protection after a single-dose administration.

Current photoacoustic contrast agents cannot be used for multiplexed imaging due to their broad absorption spectra in the visible to near-infrared range. Here, the sharp near-infrared absorption peaks of lanthanides are exploited for photoacoustic and efficient deep tissue imaging.

This Perspective lays out the impetus and goals of the Cellular Senescence Network established to comprehensively identify and characterize senescent cells (SnCs) across tissues and lifespan, providing a publicly available SnC atlas.