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DNA can store vast amounts of data, but current systems rely on many redundant copies and deep sequencing to correct synthetic, storage and readout errors. Here, authors present Gungnir, a DNA storage codec that recovers data from a single, highly error-prone sequence, reducing cost and improving reliability.

The incorporation of alkali metals in kesterite solar cells enables high efficiency but is challenging to control. Xu et al. show that combining Na and Li ions yields optimal phase formation, enabling efficient solar cells and modules.

In this work, the authors report a light-induced in-situ structural transformation strategy to facilely construct benzisoxazole-linked donor-acceptor covalent organic frameworks with enhanced performance on photocatalytic H₂O₂ synthesis.

BioMedAgent is a self-evolving LLM multi-agent framework that learns to use various bioinformatics tools and chain them into executable workflows for autonomously carrying out diverse biomedical data tasks initiated by natural-language prompts.

Atomic disorder limits the performance of kesterite solar cells. Jinlin Wang et al. introduce surface vacancy defects via magnesium doping, which reduces cation disorder and charge losses, enabling a certified efficiency of 14.9%.

This study finds that plastic mulch substantially increases crop yields but also contaminates soils and pollutes the environment. The authors propose biodegradable films, AI-driven farming, and policy reforms to address the productivity–sustainability trade-offs.

Charge loss at grain boundaries of kesterite polycrystalline absorbers limits the performance of thin film solar cells. Here, authors report the use of Pd(II)/Pd(IV) redox shuttle to assist the capture and exchange of Se atoms and eliminate vacancy defects, realizing certified efficiency of 14.3%.

Transition-metal catalyzed cross-electrophile coupling (XEC) is a powerful tool for the construction of molecules but XEC between carbon electrophile and chlorosilanes to access organosilicon compounds remains underdeveloped. Here the authors disclose a highly efficient cobalt-catalyzed cross-electrophile alkynylation of a broad range of unactivated chlorosilanes with alkynyl sulfides as a stable and practical alkynyl electrophiles.

Long, chemically modified pegRNAs are rapidly synthesized using an optimized splint ligation approach.

The authors demonstrate a multicolor optical chip which processes images using light instead of electricity, making computers faster and more energy-efficient. It could power real-time vision in drones, cars, and smart devices with much less battery drain.

The efficiency of pure-sulfide kesterite solar cells is limited by charge carrier recombination and transport. Yin, Wang, Lou, Meng et al. create a gradient of cadmium across the kesterite layer that improves charge transport and suppresses defects, enabling 13% efficiency.

The authors reveal that interfacial dead layers in ferroelectric ScAlN originate from nitrogen vacancies and strain, highlighting their critical role in unlocking the full potential of nitride ferroelectrics for advanced device architectures.

Non-oxidative alkene dehydrogenation is hindered by side reactions like cracking, iso- or polymerization, or alkyne formation. Here the authors report a Pd/TiO2 photocatalyst decorated with Ni single sites for selective ethane to ethylene production under simulated solar light conditions with high yields.

Interim analysis of the SHIELD program, adopting multilevel interventions, showcases low mother-to-child transmission (MTCT) rates of hepatitis B virus (HBV) across different hospital and community settings in China.

A layered hybrid lead halide intercalated with Ru(bpy)₃²⁺ is assembled through Pb²⁺-carboxylate coordination. The material has broad visible light absorption and drives photocatalytic CO₂ reduction to CO with a quantum yield of ~3.0% at 500 nm.

A detailed understanding of defects in kesterite solar cells is still lacking. Shi et al. identify a key defect and its formation mechanism and use alloying to suppress it, achieving solar cells with 14.2% certified efficiency.

A fast chemical reprogramming system to generate human pluripotent stem cells was developed, revealing epigenetic enzymes as key barriers and providing an innovative and promising strategy for stem cell manufacturing.

Early detection and accurate diagnosis of focal liver lesions are crucial for effective treatment and prognosis. Here, the authors present a fully automated diagnostic system that leverages multi-phase CT scans and clinical features, for diagnosing liver lesions.

The authors provide experimental evidence for giant polarization in wurtzite III-nitrides, establishing a unified framework for understanding and engineering polarization in these materials and their functional device architectures.

The applications of human extended pluripotent stem cells (which can form both embryonic and extraembryonic lineages) demand a xeno-free culture condition; here, the authors provide a chemically defined and xeno-free culture system to do so.

Human somatic cells were reprogrammed to human chemically induced pluripotent stem cells that demonstrate key features of embryonic stem cells.

Cell type deconvolution in tumor spatial transcriptomics (ST) data remains challenging. Here, the authors develop Spatial Cellular Estimator for Tumors (SpaCET) to infer cell types and intercellular interactions from ST data in cancer across different platforms, with improved performance over similar methods.

Microbial degradation of polyvinyl chloride (PVC) has previously been reported, but little is known about the degrading strains and enzymes. Here, Zhe et al. isolate a PVC-degrading bacterium from the gut of insect larvae and shed light on the PVC degradation pathway using a multi-omic approach.

Improved glycemic control after transplantation of human pluripotent stem-cell-derived islets for diabetes treatment in non-human primates.

Regulated degeneration of synergid cells is essential for reproductive success in flowering plants. Here, authors show that the persistent synergid cell secretes autocrine RALF12 signal to trigger intracellular mitochondrial ROS burst and dPCD.

Secondary phases or multi-step phase formation lead to poorly crystallized and defective kesterite films. Now Zhou et al. convert precursors into kesterite in a single step, using low partial pressure of selenium, and achieve solar cells with 13.8% certified efficiency.

The authors investigate phonon behaviors of buckled two-dimensional GaN, determining the phonon dispersion of buckled two-dimensional GaN, revealing a larger phonon band gap compared to bulk GaN.

Initial results of serological surveillance in China provide valuable data for estimation of the cumulative prevalence of SARS-CoV-2 infection in the general population.

Despite their promising optical properties, organolead halide perovskites are not frequently used in photocatalysis due to their low stability in water. Here, a long-lasting semiconductive organolead iodide layered crystalline material with the ability to perform overall water splitting is introduced.

Ultrathin 10.2-nm-thick (~λ/30,000) Ti₃C₂T_x MXene assemblies that offer an absorption of 49.2%, which is close to the theoretical limit of 50%, in the range of 0.5–10 THz are reported, benefiting terahertz optoelectronic and photothermoelectric devices.

Given associations between colitis and myelodysplastic syndrome (in which nucleophosmin 1 is often mutated), the authors here look at the contribution of nucleophosmin 1 to colitis, showing that it is important for protection mediated by ILC3s owing to effects on mitochondrial metabolism.

The role of enhancer variants in hepatocellular carcinoma (HCC) predisposition remains unknown. Here, the authors perform a genome-wide survey of HCC-susceptible enhancer variants in 11,958 individuals, identify rs73613962 within the intronic region of PRMT7 and find that PRMT7 upregulation predisposes to HCC.

Although they tend to exhibit exciting optoelectronic behaviours, the difficulty in fabricating chemically bonded two-dimensional layered heterojunctions has hindered progress in the area. Here, the authors synthesize sandwich-substructured Bi₂WO₆monolayers and investigate their photocatalytic activity.

Oesophageal squamous-cell carcinoma (ESCC) is a leading cause of cancer death, and half of ESCC cases occur in China. Here, the authors provide an in depth genomic landscape for this disease and identify specific mutation signatures—one of which is linked to alcohol intake.