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Scientific Reports (46)
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Showing 1–50 of 131 results

Advanced filters: Author: Jinling Huang Clear advanced filters

Hepatic GPR110 contributes to sex disparity in the development of MASH through oestrogen receptor α-dependent signalling

Hepatocyte-specific GPR110 mediates metabolic dysfunction-associated steatohepatitis progression by regulating hepatic oestrogen sensitivity in a sex-specific manner, specifically in female mice.

Fang Yang
Wei Wang
Zhe Huang
Research05 Jan 2026
Nature Metabolism

Volume: 8, P: 116-138
A clinically applicable deep-learning model for detecting intracranial aneurysm in computed tomography angiography images

Interpretation of Computed Tomography Angiography for intracranial aneurysm diagnosis can be time-consuming and challenging. Here, the authors present a deep-learning-based framework achieving improved performance compared to that of radiologists and expert neurosurgeons.

Zhao Shi
Chongchang Miao
Long Jiang Zhang
ResearchOpen Access30 Nov 2020
Nature Communications

Volume: 11, P: 1-11
Electronegativity and entropy design of layered oxides for sodium-ion batteries

The structure of layered oxides dictates their properties as positive electrodes in sodium-ion batteries, but its rational design remains challenging. Here, authors employ electronegativity and configurational entropy as a design descriptor to guide the synthesis of a sodium-deficient layered oxide with an O3 stacking sequence, rendering good thermal and air stability.

Lu Gan
Hu-Rong Yao
Yu-Guo Guo
ResearchOpen Access08 Jan 2026
Nature Communications

Volume: 17, P: 1-11
Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice

OPC-vascular coupling contributes to myelin maintenance. Here the authors show Cav-1 stabilizes interactions and mediates OPC maturation in ischemia.

Ying Zhao
Wusheng Zhu
Xinfeng Liu
ResearchOpen Access10 Nov 2022
Nature Communications

Volume: 13, P: 1-20
Charting brain morphology in international healthy and neurological populations

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Zhizheng Zhuo
Li Chai
Yaou Liu
Research29 Dec 2025
Nature Neuroscience

P: 1-15
Levels of Faecal Calprotectin and Magnetic Resonance Enterocolonography Correlate with Severity of Small Bowel Crohn’s Disease: A Retrospective Cohort Study

Lei Ye
Wei Cheng
Fang-yu Wang
ResearchOpen Access16 May 2017
Scientific Reports

Volume: 7, P: 1-8
The association between enema and nervous system injury in Diquat poisoning

Xiang Xue
Jiankang Meng
Shinan Nie
ResearchOpen Access17 May 2025
Scientific Reports

Volume: 15, P: 1-8
NAT10-mediated upregulation of GAS5 facilitates immune cell infiltration in non-small cell lung cancer via the MYBBP1A-p53/IRF1/type I interferon signaling axis

Zimu Wang
Jing Luo
Yong Song
ResearchOpen Access18 May 2024
Cell Death Discovery

Volume: 10, P: 1-13
Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway

Leilei Tao
Guichun Huang
Longbang Chen
ResearchOpen Access06 Dec 2016
Scientific Reports

Volume: 6, P: 1-13
Baseline and change in serum lipid and uric acid level over time and incident of nonalcoholic fatty liver disease (NAFLD) in Chinese adults

Ya Huang
Tao Jin
Yong Zhong
ResearchOpen Access09 Aug 2024
Scientific Reports

Volume: 14, P: 1-9
Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial

Bibo Wang
Neng Wang
Guojun Qian
ResearchOpen Access19 Mar 2024
Scientific Reports

Volume: 14, P: 1-8
Renal Prognosis and Related Risk Factors for Henoch-Schönlein Purpura Nephritis: A Chinese Adult Patient Cohort

Xiao Huang
Xiaomei Wu
Zheng Tang
ResearchOpen Access03 Apr 2018
Scientific Reports

Volume: 8, P: 1-8
Multiplexed bulk and single-cell RNA-seq hybrid enables cost-efficient disease modeling with chimeric organoids

IPSC-derived organoids model diseases. Multiplexed coculture and demultiplexing natural genetic barcodes aid in studying genetic effects. Here, authors introduce Vireo-bulk to deconvolve bulk RNA-seq data, quantify donor abundance and identify differentially expressed genes.

Chen Cheng
Gang Wang
Jin Zhang
ResearchOpen Access10 May 2024
Nature Communications

Volume: 15, P: 1-12
Chemotherapy-induced high expression of IL23A enhances efficacy of anti-PD-1 therapy in TNBC by co-activating the PI3K-AKT signaling pathway of CTLs

Fan Pan
Jiajing Liu
Guichun Huang
ResearchOpen Access20 Jun 2024
Scientific Reports

Volume: 14, P: 1-15
Bryophytes hold a larger gene family space than vascular plants

A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

Shanshan Dong
Sibo Wang
Yang Liu
ResearchOpen Access22 Sept 2025
Nature Genetics

Volume: 57, P: 2562-2569
Visceral to subcutaneous fat area ratio predicts severe abdominal adhesions in definitive surgery for anastomotic fistula after small intestine resection

Fan Yang
Weiliang Tian
Qian Huang
ResearchOpen Access17 Aug 2024
Scientific Reports

Volume: 14, P: 1-9
Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice

Ischemic stroke can cause secondary demyelination. Whether phagocytic astrocytes can contribute to such demyelination is unclear. Here, the authors show that lipocalin-2 (LCN-2) expression increased in astrocytes upon injury. LCN-2 expressing astrocytes acquire a phagocytic phenotype and contribute to secondary demyelination in a mouse model of ischemic stroke.

Ting Wan
Wusheng Zhu
Xinfeng Liu
ResearchOpen Access03 Mar 2022
Nature Communications

Volume: 13, P: 1-18
Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma

Jialu Li
Yang Liu
Yi Ba
ResearchOpen Access07 Aug 2015
Scientific Reports

Volume: 5, P: 1-13
Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial

In a phase 1 trial, the co-infusion of CD19-targeting and BCMA-targeting CAR-T cells in adults with treatment-refractory lupus was safe and had promising efficacy, with most patients achieving remission after 3 months.

Jingjing Feng
Dawei Huo
He Huang
Research24 Sept 2025
Nature Medicine

Volume: 31, P: 3725-3736
A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing

Diabetic wounds are challenging to heal, with vascular injury induced by high glucose a key pathological factor. Here, the authors report a hydrogel designed to interrupt the process of vascular injury, with angiogenic capacity.

Jinjian Huang
Rong Yang
Jianan Ren
ResearchOpen Access29 Nov 2023
Nature Communications

Volume: 14, P: 1-20
Hypoxia induced CCL28 promotes angiogenesis in lung adenocarcinoma by targeting CCR3 on endothelial cells

Guichun Huang
Leilei Tao
Longbang Chen
ResearchOpen Access02 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
Value of red blood cell distribution width in evaluating 2019-nCoV infection in neonates: a retrospective study

Han Li
Qian Wang
Qinyu Ge
ResearchOpen Access07 Dec 2025
Scientific Reports

Volume: 16, P: 1-7
Metadherin regulates proliferation and metastasis via actin cytoskeletal remodelling in non-small cell lung cancer

Y Yao
X Gu
Y Song
ResearchOpen Access10 Jun 2014
British Journal of Cancer

Volume: 111, P: 355-364
A de novo evolved gene contributes to rice grain shape difference between indica and japonica

Genetic bases of grain shape differentiation between the two subspecies of Asian cultivated rice have not been fully elucidated. Here, the authors report GSE9, a de novo gene evolved from a non-coding region of wild rice through acquisition of start codon, contributes to the grain shape difference between the two subspecies.

Rujia Chen
Ning Xiao
Zefeng Yang
ResearchOpen Access22 Sept 2023
Nature Communications

Volume: 14, P: 1-13
Acute kidney injury during autologous stem cell transplantation in light chain amyloidosis with kidney involvement and their impact on prognosis

Weiwei Xu
Wencui Chen
Xianghua Huang
Research24 Apr 2024
Bone Marrow Transplantation

Volume: 59, P: 1076-1083
Single-cell transcriptomes reveal a molecular link between diabetic kidney and retinal lesions

Single-cell transcriptome data reveal analogous gene expression patterns between renal mesangial cells and retinal pericytes and imply similarities between the molecular events that cause diabetic nephropathy and diabetic retinopathy.

Ying Xu
Zhidan Xiang
Zhihong Liu
ResearchOpen Access05 Sept 2023
Communications Biology

Volume: 6, P: 1-12
Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study reports the horizontal gene transfer of CSP genes from bacteria to Triticeae, promoting the adaptation and spread of wheat through enhanced drought tolerance and photosynthetic efficiency.

Kai Wang
Guanghui Guo
Chun-Peng Song
Research27 Mar 2025
Nature Plants

Volume: 11, P: 761-774
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs

The authors show that SARS-CoV-2-specific T cells in the lung are key to fighting infection and persist after viral clearance, contributing to long-term immunity and protection.

Airu Zhu
Zhao Chen
Jincun Zhao
ResearchOpen Access28 Jan 2025
Nature Immunology

Volume: 26, P: 459-472
Clinicopathologic characteristics and prognostic analysis of monoclonal gammopathy of renal significance (MGRS) in patients with IgM monoclonal gammopathy: a case series

Jing Liu
Dandan Liang
Jinhua Hou
ResearchOpen Access10 Oct 2022
Scientific Reports

Volume: 12, P: 1-9
Author Correction: A mycorrhizae-like gene regulates stem cell and gametophore development in mosses

Shuanghua Wang
Yanlong Guan
Jinling Huang
Amendments and CorrectionsOpen Access04 Jun 2020
Nature Communications

Volume: 11, P: 1
MicroRNA-199a-5p promotes tumour growth by dual-targeting PIAS3 and p27 in human osteosarcoma

Chen Wang
Ximing Ba
Jiangning Chen
ResearchOpen Access25 Jan 2017
Scientific Reports

Volume: 7, P: 1-12
Cholesterol biosynthesis induced by radiotherapy inhibits cGAS–STING activation and contributes to colorectal cancer treatment resistance

Lijun Zhu
Zhaohui Tang
Yanhong Gu
ResearchOpen Access12 May 2025
Experimental & Molecular Medicine

Volume: 57, P: 1089-1105
Engineering a heparin-mimetic biomaterial to promote tissue vascularization

Synthetic heparin-mimetic hydrogels immobilize angiogenic growth factors to promote tissue vascularization, providing salient properties of heparin-containing materials in promoting angiogenesis without the associated risk of bleeding.

Linqing Li
Jinling Yang
Christopher S. Chen
ResearchOpen Access14 Nov 2025
Communications Biology

Volume: 8, P: 1-11
Introgressing the Aegilops tauschii genome into wheat as a basis for cereal improvement

An introgression platform for transferring genetic variations of Aegilops tauschii to hexaploid wheat is established based on synthetic octoploid wheat. Combined with newly generated genome resources of A. tauschii, it represents a powerful tool for wheat gene discovery and breeding.

Yun Zhou
Shenglong Bai
Chun-Peng Song
Research27 May 2021
Nature Plants

Volume: 7, P: 774-786
Risk factors, treatments and outcomes of patients with light chain amyloidosis who relapse after autologous stem cell transplantation

Yuanyuan Zhang
Jinzhou Guo
Xianghua Huang
Research26 Dec 2023
Bone Marrow Transplantation

Volume: 59, P: 350-358
Dynamic changes in anti-SARS-CoV-2 antibodies during SARS-CoV-2 infection and recovery from COVID-19

Understanding antibody responses to Sars-CoV-2 proteins over time is complicated by many variables. Here the authors survey IgM and IgG antibodies against S protein, RBD and nucleoprotein in a large cohort of infected and recovering severe vs. moderate COVID-19 patients, comparing against clinical parameters and immunological readouts.

Kening Li
Bin Huang
Xinyi Xia
ResearchOpen Access27 Nov 2020
Nature Communications

Volume: 11, P: 1-11
A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF

Here the authors report an NIR-II gold probe for identification of early-stage AD. The probe enables non-invasive NIR-II imaging of elevated CTGF in brains of early AD mice and multimodally identifying AD patients’ brain sections before obvious Aβ deposition.

Cao Lu
Cong Meng
Xueyun Gao
ResearchOpen Access12 Jun 2024
Nature Communications

Volume: 15, P: 1-15
Genomes of multicellular algal sisters to land plants illuminate signaling network evolution

Genome assemblies of four filamentous Zygnematophyceae and co-expression network analyses shed light on the evolutionary roots of the mechanism for balancing environmental responses and multicellular growth.

Xuehuan Feng
Jinfang Zheng
Yanbin Yin
ResearchOpen Access01 May 2024
Nature Genetics

Volume: 56, P: 1018-1031
IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation

Lai and colleagues show that the RNA helicase DDX5 mediates the alternative splicing of the IL-36R mRNA in keratinocytes and modulates skin inflammation downstream of IL-17D signaling.

Xinhui Ni
Yi Xu
Yuping Lai
ResearchOpen Access21 Oct 2022
Nature Immunology

Volume: 23, P: 1577-1587
Effects of manure application on paddy soil phosphorus in China based on a meta-analysis

Shuangfeng Liu
Chaoyang Liang
Jinling Xu
ResearchOpen Access16 Oct 2025
Scientific Reports

Volume: 15, P: 1-12
Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature

Development of pan-drug resistance and hypervirulence in Rhodosporidiobolus fluvialis are enabled by mutagenesis induced by mammalian body temperature.

Jingjing Huang
Pengjie Hu
Linqi Wang
Research19 Jun 2024
Nature Microbiology

Volume: 9, P: 1686-1699
Global urbanicity is associated with brain and behaviour in young people

Xu et al. show that satellite-measured urbanicity (living in a densely populated area) is correlated with brain volume, cortical surface area and brain network connectivity in a sample of 3,867 people from China and Europe.

Jiayuan Xu
Xiaoxuan Liu
Gunter Schumann
Research28 Oct 2021
Nature Human Behaviour

Volume: 6, P: 279-293
Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest

Chao Li
Yuming Feng
Ying Xu
ResearchOpen Access02 Aug 2022
Cell Death Discovery

Volume: 8, P: 1-15
A mycorrhizae-like gene regulates stem cell and gametophore development in mosses

Plant evolution is intimately associated with fungal partners. Here the authors provide evidence that Physcomitrella patens MACRO2, a gene likely derived from early mycorrhizae-like fungi, was transferred to early land plants and plays an important role in regulating stem cell growth and gametophore development in moss.

Shuanghua Wang
Yanlong Guan
Jinling Huang
ResearchOpen Access24 Apr 2020
Nature Communications

Volume: 11, P: 1-11
An androgen receptor negatively induced long non-coding RNA ARNILA binding to miR-204 promotes the invasion and metastasis of triple-negative breast cancer

Fang Yang
Yan Shen
Xiaoxiang Guan
Research29 May 2018
Cell Death & Differentiation

Volume: 25, P: 2209-2220
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells

Jun Jing
Ning Ding
Bing Yao
ResearchOpen Access14 Aug 2020
Cell Death & Disease

Volume: 11, P: 1-15
Widespread impact of horizontal gene transfer on plant colonization of land

Although horizontal gene transfer is prevalent in microorganisms, such sharing of genetic information is thought to be rare in land plants. Focusing on the sequenced moss species,Physcomitrella patens, these authors report genes acquired from microorganisms, which might have facilitated early evolution of land plants.

Jipei Yue
Xiangyang Hu
Jinling Huang
ResearchOpen Access23 Oct 2012
Nature Communications

Volume: 3, P: 1-9
The evolution of photosynthesis in chromist algae through serial endosymbioses

The chromalveolate hypothesis proposes that chromist algae became photosynthetic through a single endosymbiosis in a common ancestor. Here, Stiller et al. use a novel statistical approach to propose that instead, the major chromist algae arose as a result of three specific serial plastid transfers.

John W. Stiller
John Schreiber
Jinling Huang
ResearchOpen Access10 Dec 2014
Nature Communications

Volume: 5, P: 1-7
Author Correction: Multiplexed bulk and single-cell RNA-seq hybrid enables cost-efficient disease modeling with chimeric organoids

Chen Cheng
Gang Wang
Jin Zhang
Amendments and CorrectionsOpen Access05 Jun 2024
Nature Communications

Volume: 15, P: 1
Elevated serum complement factors 3 and 4 are strong inflammatory markers of the metabolic syndrome development: a longitudinal cohort study

Zhenfang Liu
Qin Tang
Xiaobo Yang
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-8

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