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Showing 1–50 of 3533 results

Advanced filters: Author: John D Johnson Clear advanced filters

Native H₂ pathways enable biocompatible hydrogenation of metabolic alkenes in bacteria

Most H₂ used in the chemical industry is derived from fossil fuels. Now it has been shown that coupling native microbial H₂ pathways with engineered alkene biosynthesis and membrane-bound Pd catalysis enables biocompatible hydrogenation of metabolic intermediates in living bacteria. This hybrid chemo-microbial platform supports the carbon-negative synthesis of industrial chemicals from waste-derived feedstocks.

Mirren F. M. White
Connor L. Trotter
Stephen Wallace
ResearchOpen Access23 Feb 2026
Nature Chemistry

Volume: 18, P: 535-543
Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990–2023: a Global Burden of Disease study

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Sooji Lee
Hayeon Lee
Dong Keon Yon
Research30 Mar 2026
Nature Medicine

P: 1-25
Generalization of fear learning is shaped by inhibitory sensory processing in mice

Fear generalization allows learned threats to extend to similar stimuli, but the early sensory mechanisms involved are unclear. Here, authors show that fear conditioning reduces GABAB inhibition in the olfactory bulb scaled to odor similarity, and that bidirectional manipulation of this inhibition controls breadth of fear generalization.

Alper K. Bakir
Ankur A. Gaikwad
John P. McGann
ResearchOpen Access03 Apr 2026
Nature Communications

P: 1-13
Natural and anthropogenic causes of lake acidification in Nova Scotia

Eville Gorham
John K. Underwood
J. Gordon Ogden III
Research04 Dec 1986
Nature

Volume: 324, P: 451-453
Investigating the analytical robustness of the social and behavioural sciences

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Balazs Aczel
Barnabas Szaszi
Brian A. Nosek
Research01 Apr 2026
Nature

Volume: 652, P: 135-142
Semaglutide on liver fibrosis and heart outcomes in patients at high risk of liver fibrosis: a prespecified analysis of the SELECT randomized trial

A prespecified analysis from the SELECT trial showed that semaglutide reduces major adverse cardiovascular events by 20% compared with placebo, particularly in patients at high risk of fibrosis, as indicated by the Fibrosis-4 index.

Sebastian M. Meyhöfer
Bertrand Cariou
Christoffer W. Tornøe
ResearchOpen Access02 Apr 2026
Nature Medicine

P: 1-8
Genetic modifiers of APOE-ε4-associated cognitive decline

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Alex G. Contreras
Skylar Walters
Timothy J. Hohman
ResearchOpen Access20 Feb 2026
Nature Communications

Volume: 17, P: 1-17
Evidence for odd-parity superconductivity underpinned by antiferromagnetism in heavy-fermion metal YbRh₂Si₂

Odd-parity spin-triplet superconductivity remains difficult to establish experimentally. Now, several distinct magnetic-field-tuned superconducting states—including a possible topological helical phase—have been identified in YbRh₂Si₂.

Lev V. Levitin
Jan Knapp
John Saunders
ResearchOpen Access03 Apr 2026
Nature Physics

P: 1-7
NEO-STIM advances personalized neoantigen-specific adoptive T cell therapy

Neoantigen-based adoptive T cell therapies represent a personalized approach for cancer immunotherapy. Here the authors describe NEO-STIM, an ex vivo T cell induction platform to STIMulate peripheral blood T cells to generate responses against tumor NEOantigens.

Divya Lenkala
Jessica Kohler
Marit M. van Buuren
ResearchOpen Access05 Feb 2026
Nature Communications

P: 1-17
Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria

C. Ruwende
S. C. Khoo
A. V. S. Hill
Research20 Jul 1995
Nature

Volume: 376, P: 246-249
Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

Wayne A. Border
Nancy A. Noble
Erkki Ruoslahti
Research26 Nov 1992
Nature

Volume: 360, P: 361-364
Munc13-4–STX7 inhibitors impair endosomal TLR activation and systemic inflammation

Endosomal Toll-like receptors (TLRs) are central to the innate immune response but their overactivation can cause systemic inflammation and disease. Now, new small molecules targeting the interaction between Munc13-4 and syntaxin 7 essential for endosomal maturation impair overactivation of endosomal TLR-dependent pathways and inflammation.

Jennifer L. Johnson
Elsa Meneses-Salas
Sergio D. Catz
ResearchOpen Access06 Apr 2026
Nature Chemical Biology

P: 1-14
A sorghum pangenome reference improves global crop trait discovery

A pangenome reference for the phenotypically diverse crop sorghum aims to help accelerate future efforts to breed crops that are better adapted to changing environments.

Geoffrey P. Morris
Avril M. Harder
John T. Lovell
ResearchOpen Access11 Mar 2026
Nature

P: 1-9
Global health benefits and cost-effectiveness of indoor air purification to mitigate PM_2.5 from wildfire smoke

Air purification could avert 60 million disability-adjusted life years (DALYs) from wildfire-related fine particulate matter (PM_2.5) and 2.2 billion DALYs from all-source PM_2.5 globally, according to a global assessment integrating health gains and economic feasibility.

Dongjia Han
Yongxuan Guo
Bin Zhao
Research07 Apr 2026
Nature Health

P: 1-15
Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity

An analysis of whole-exome sequencing data linked to longitudinal electronic health records from 44,028 British South Asians finds new gene–phenotype associations and identifies 2,991 genes with rare biallelic predicted loss-of-function genotypes.

Hye In Kim
Christopher DeBoever
David A. van Heel
ResearchOpen Access27 Mar 2026
Nature Genetics

P: 1-10
Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing

Testosterone produced by skin cells enhances Staphylococcus aureus pathogenicity by activating quorum sensing, and a stereoisomer of testosterone that blocks this interaction inhibits bacterial cytotoxicity towards human cells.

Maria Sindhura John
Mahendran Chinnappan
Tamia A. Harris-Tryon
ResearchOpen Access27 Feb 2026
Nature Microbiology

Volume: 11, P: 704-717
Radiofrequency cascade readout of coupled spin qubits

A dispersive sensing technique, termed the radiofrequency electron cascade, can perform singlet-triplet readout of two exchange-coupled electron spins in a natural silicon planar metal–oxide–semiconductor quantum-dot array.

Jacob F. Chittock-Wood
Ross C. C. Leon
M. Fernando Gonzalez-Zalba
ResearchOpen Access30 Mar 2026
Nature Electronics

Volume: 9, P: 314-323
Implementation of the NHS England Lung Cancer Screening Programme over 5 years

Over five years, implementation of the NHS England Lung Cancer Screening Programme achieved high early-stage detection rates and demonstrated that the programme is both feasible and scalable for reaching high-risk and underserved populations.

Richard W. Lee
Arjun Nair
Tim Windle
ResearchOpen Access23 Mar 2026
Nature Medicine

P: 1-10
Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution

Experimental evolution of fission yeast (Schizosaccharomyces pombe) in the same environment as a previous experiment with budding yeast (Saccharomyces cerevisiae) reveals parallel evolution but distinct molecular mechanisms and targets of adaptation in the two species.

Arnaud N’Guessan
Vivian Wang
Alex N. Nguyen Ba
ResearchOpen Access13 Mar 2026
Nature Ecology & Evolution

Volume: 10, P: 765-778
Olfactory cleft biopsy analysis of Alzheimer’s disease pathobiology across disease stages

Using nasal brush biopsies from the olfactory region, single-cell profiling revealed neuroimmune alterations in Alzheimer’s Disease detectable at a pre-clinical stage, offering an accessible window into early neurodegenerative disease in humans.

Vincent M. D’Anniballe
Sarah Kim
Bradley J. Goldstein
ResearchOpen Access18 Mar 2026
Nature Communications

Volume: 17, P: 1-13
Predicting onset of symptomatic Alzheimerʼs disease with plasma p-tau217 clocks

Plasma p-tau217 tests used to develop clocks that predict when cognitively unimpaired individuals would develop symptoms of Alzheimerʼs disease.

Kellen K. Petersen
Marta Milà-Alomà
Suzanne E. Schindler
ResearchOpen Access19 Feb 2026
Nature Medicine

Volume: 32, P: 1085-1094
Empiric azithromycin alters the upper respiratory microbiome and resistome without anti-inflammatory benefit in COVID-19

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Abigail Glascock
Cole Maguire
Charles R. Langelier
ResearchOpen Access16 Mar 2026
Nature Microbiology

Volume: 11, P: 1100-1112
Tucatinib–trastuzumab–capecitabine for treatment of leptomeningeal metastasis in women with HER2⁺ breast cancer: TBCRC049 phase 2 study results

Murthy and colleagues discussed recent research on the effect of a tucanitib–trastuzumab–capecitabine regimen in patients with HER2⁺ breast cancer and leptomeningeal metastasis.

Rashmi K. Murthy
Barbara J. O’Brien
Erica M. Stringer-Reasor
ResearchOpen Access18 Mar 2026
Nature Cancer

Volume: 7, P: 424-434
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations

Glioblastoma is characterised by high levels of intratumoural heterogeneity and plasticity, hindering treatment. Here, the authors develop an analytical framework, scFOCAL, to predict the sensitivity of glioblastoma cell subpopulations to therapies based on reversal of disease transcriptional signatures to identify synergistic therapeutic combinations.

Robert K. Suter
Anna M. Jermakowicz
Nagi G. Ayad
ResearchOpen Access07 Jan 2026
Nature Communications

Volume: 17, P: 1-18
Structure of Vitamin B₁₂: X-ray Crystallographic Evidence on the Structure of Vitamin B₁₂

CLARA BRINK
DOROTHY CROWFOOT HODGKIN
JOHN G. WHITE
Research25 Dec 1954
Nature

Volume: 174, P: 1169-1171
CD4⁺ T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy

An in-depth analysis of tissue biopsies from patients with multiple myeloma and CAR T cell therapy-associated immune-related adverse events (CirAEs) after treatment with commercial BCMA-targeted CAR T cell therapy shows that CD4⁺ CAR T cells mediate off-tumor toxicities and that high CD4:CD8 ratio at apheresis, robust early CAR T cell expansion, ICANS and ciltacabtagene autoleuce treatment are independently associated with the development of CirAEs.

Matthew Ho
Luca Paruzzo
Joseph A. Fraietta
Research15 Jan 2026
Nature Medicine

Volume: 32, P: 702-716
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Dredged basalts from the mid-oceanic ridge north of Iceland

Finn Dittmer
Stanley Fine
John Campsie
Research27 Mar 1975
Nature

Volume: 254, P: 298-301
cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Eric Van Buren
Yi Zhang
Xihong Lin
Research31 Dec 2025
Nature Methods

Volume: 23, P: 338-349
Modelling Hepatic Endoderm Development: Highly Efficient Differentiation of Human Embryonic Stem Cells to Functional Hepatic Endoderm Requires ActivinA and Wnt3a Signalling.

David Hay
Judy Fletcher
John Iredale
ResearchOpen Access10 Jan 2008
Nature Precedings

P: 1
Modelling Hepatic Endoderm Development: Highly Efficient Differentiation of Human Embryonic Stem Cells to Functional Hepatic Endoderm Requires ActivinA and Wnt3a Signalling.

David Hay
Judy Fletcher
John Iredale
ResearchOpen Access26 Dec 2007
Nature Precedings

P: 1
Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer

A pan-haematologic cancer approach, involving analysis of data from 256 patients across 5 cancer types and 13 clinical trials, revealed predictive biomarkers for understanding the response or non-response of patients to CAR-T therapy.

Gregory M. Chen
Ankita Jain
Joseph A. Fraietta
Research09 Mar 2026
Nature Biomedical Engineering

P: 1-12
Sequence homologies near the C-termini of the variable surface glycoproteins of Trypanosoma brucei

Allison C. Rice-Ficht
Kenneth K. Chen
John E. Donelson
Research05 Nov 1981
Nature

Volume: 294, P: 53-57
Severe and widespread coral reef damage during the 2014-2017 Global Coral Bleaching Event

From 2014–2017, marine heatwaves caused global mass coral bleaching, where the corals lose their symbiotic algae. The authors find, this event exceeded the severity of all prior global bleaching events in recorded history, with approximately half the world’s reefs bleaching and 15% experiencing substantial mortality.

C. Mark Eakin
Scott F. Heron
Derek P. Manzello
ResearchOpen Access10 Feb 2026
Nature Communications

Volume: 17, P: 1-14
Tumor-informed circulating tumor DNA stratifies recurrence risk and survival in anal squamous cell carcinoma

Prediction of tumour recurrence in anal squamous cell carcinoma can be challenging. Here, the authors use a tumour-informed ctDNA assay to show concordance with relapse in patients following failed definitive-intent chemoradiation.

Paul B. Romesser
Aron Bercz
Richard Tuli
ResearchOpen Access26 Feb 2026
Nature Communications

Volume: 17, P: 1-9
John Howard Northrop (1891–1987)

John T. Edsall
News & Views01 Oct 1987
Nature

Volume: 329, P: 396
Double Helix at Atomic Resolution

JOHN M. ROSENBERG
NADRIAN C. SEEMAN
ALEXANDER RICH
Research18 May 1973
Nature

Volume: 243, P: 150-154
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Esther Rheinbay
Morten Muhlig Nielsen
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature

Volume: 578, P: 102-111
Structure of southern bean mosaic virus at 2.8 Å resolution

Celerino Abad-Zapatero
Sherin S. Abdel-Meguid
Tomitake Tsukihara
Research03 Jul 1980
Nature

Volume: 286, P: 33-39
1139 PARATHYROID (PTH) AND ANTIDIURETIC HORMONE (ADH) IN REYE-JOHNSON SYNDROME (RJS)

Ellen S Kano
Genaro M A Palmieri
John F Griffith
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 632
Calcium transients in aequorin-injected frog cardiac muscle

David G. Allen
John R. Blinks
Research15 Jun 1978
Nature

Volume: 273, P: 509-513
Paracoccus denitrificans and the evolutionary origin of the mitochondrion

Philip John
F. R. Whatley
Research01 Apr 1975
Nature

Volume: 254, P: 495-498
Monitoring treatment response using an ultra-sensitive ctDNA assay in advanced esophagogastric cancer patients

Andrew B. Nixon
Fábio C. P. Navarro
Hope Uronis
ResearchOpen Access23 Mar 2026
Scientific Reports

P: 1-11
Chloroplast protein phosphorylation couples plastoquinone redox state to distribution of excitation energy between photosystems

John F. Allen
John Bennett
Charles J. Arntzen
Research07 May 1981
Nature

Volume: 291, P: 25-29
Inhibition of mutant troponin C activity by an intra-domain disulphide bond

Zenon Grabarek
Ruo-Ying Tan
John Gergely
Research10 May 1990
Nature

Volume: 345, P: 132-135
Calculation of Chemical Equilibria in Volcanic Systems by Means of Computers

EMERSON F. HEALD
JOHN J. NAUGHTON
Research17 Feb 1962
Nature

Volume: 193, P: 642-644
Structure of Vitamin B₁₂ : The Crystal Structure of the Hexacarboxylic Acid derived from B₁₂ and the Molecular Structure of the Vitamin

DOROTHY CROWFOOT HODGKIN
JENNY PICKWORTH
JOHN G. WHITE
Research20 Aug 1955
Nature

Volume: 176, P: 325-328
Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease — a contiguous gene syndrome

Phillip T. Brook-Carter
Belén Peral
Julian R. Sampson
Research01 Dec 1994
Nature Genetics

Volume: 8, P: 328-332
Surface tension and contact with soft elastic solids

Solid contacts on a microscopic level are widely described by a classical contact mechanics theory. Here Styleet al.show that this theory breaks down when a small particle adheres to a soft surface where a fluid-like behaviour is observed because of the predominant role played by surface tension.

Robert W. Style
Callen Hyland
Eric R. Dufresne
Research07 Nov 2013
Nature Communications

Volume: 4, P: 1-6

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