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This study shows that while both zero and negative CO₂ emissions lead to a further rise in land precipitation compared to CO₂ doubling in idealized climate model simulations, extremes in the terrestrial hydrological cycle can only be effectively alleviated under negative emissions.

Engineering excitation wavelength of photosensitizers allows to enhanced reactive oxygen species but controlling the wavelength corresponding to operating conditions remains challenging. Here, the authors implement a wavelength-engineerable imidazolium-based porous organic polymer and demonstrate tuning of the optimal wavelength for maximum performance by modifying the linker system.

As soft electronic waste becomes an urgent concern, biodegradable yet high-performance devices are emerging as a promising solution. Here the authors fabricate durable and multifunctional soft robotic fingers in which both polymers and inorganic electronics are fully compostable.

The orbital Hall effect involves the transport of orbital angular momentum perpendicular to an applied charge current, analogous to the spin Hall effect. Here, Lee et al examine magnetic torques present in a Nickel/Tantalum bilayer, clearly demonstrating the contribution of the orbital Hall effect.

Currently reported early-diagnostic method for Pancreatic Ductal Adenocarcinoma (PDAC) tends to be invasive and usually time-consuming. Here, this group reports an early diagnostic method of PDAC using a signal-enhanced lateral flow immunoassay which can generate a strong colorimetric signal through multiple hotspots formed by plasmonic gold nanoparticles assembled on silica nanoparticles.

A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses in temporary cardiac pacing.

Whole-genome and transcriptome analysis of 1,364 cases of breast cancer from South Korea broadens our understanding of breast cancer biology and reveals genomic features that connect tumour biology with treatment responses and clinical outcomes.

The identity of catalytic sites for H₂O₂ generation in carbon-based materials remains controversial with limited experimental evidence to date. Here, the authors decorate various target functional groups on carbon materials and quinone-enriched samples exhibit the highest activity and selectivity.

Identification of active sites is one of the main obstacles to rational design of catalysts for scientific and industrial applications. Here, the authors demonstrate the synthesis and structural identification of Zn based active sites, as well as the related structural activation for oxygen species.

A major challenge for spin based electronics is the electrical control of magnetization. Here, Kang et al demonstrate how electric field control of the Rashba effect in a Pt/Co/AlOx can enable control of the spin-orbit torque and allow for field free switching of the magnetization.

Random atmospheric fluctuations can trigger a collapse of the Atlantic Meridional Overturning Circulation under stabilized CO₂ concentration based on simulations, underscoring high climate uncertainty and the urgent need for timely mitigation.

Hyung-Lae Kim and colleagues report a genome-wide association study of quantitative traits of biomedical importance in Koreans. Although some loci were previously detected in European populations, others are new.

Fabrication of fully stretchable organic light-emitting diodes incorporating an intrinsically stretchable exciplex-assisted phosphorescent layer along with MXene-contact stretchable electrodes is described, demonstrating high efficiency and mechanical compliance for applications in next-generation wearable and deformable displays.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Autostereoscopic three-dimensional displays allow the perception of depth, by presenting offset images to the left and right eye, without the need for specialized glasses. Yoonet al propose a Luciusmicroprism array to control the directionality and intensity of light in three-dimensional displays.

The physical properties of gel materials makes them attractive options in various applications, but supramolecular gels typically lack mechanical strength. Here, the authors present a calix[4]arene-based supramoleculer gel tuned to possess high tensile strength.

Porous organic networks are of great fundamental and technological interest. Here, the authors synthesize a three-dimensional porous organic network with high specific surface area via a solid-state explosive reaction of hexaethynyl triptycene single crystals containing primer molecules.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Ruthenium nanoparticles homogeneously dispersed in a nitrogenated, two-dimensional carbon matrix show high turnover frequency and small overpotential for hydrogen evolution reaction both in acidic and alkaline media.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

HMGCR is upregulated by E2F1, driving ferroptosis resistance by reducing oxidative damage triggered by T cell-based therapy. Notably, targeting HMGCR restores ferroptosis sensitivity in immune-refractory tumors, enhancing response to PD-1 blockade as well as adoptive T cell transfer therapy.

Ferrimagnetic multilayers and alloys are shown to have an interesting thickness dependence of spin coherence length and spin torque efficiency. These results pave the way toward energy-efficient spintronics.

Antiferromagnetic materials allow deterministic spin–orbit torque switching of perpendicular magnetization in ferromagnetic layers without external magnetic fields.

Disposable filters are generally used for air purification despite frequent replacement and waste generation problems. Here, a ceramic catalyst filter is introduced as a new class of filter that simultaneously removes PMs and VOCs as primary air pollutants and can be regenerated and used for long periods by simple water washing.

Researchers identified three distinct white matter hyperintensity progression patterns, validated in both patients and healthy individuals. Each pattern links to different vascular risks and outcomes, improving stroke prediction.

Tobacco smoking is an important risk factor for lung cancer. Here the authors report that tobacco carcinogens promote metabolic syndrome and metabolic reprogramming of macrophages, associated with lung cancer progression in preclinical models.

Systemically administered piezoelectric nanoparticles producing nitric oxide and generating direct current under high-intensity focused ultrasound can be used to stimulate deep tissue in the brain, as shown in a mouse model of Parkinson’s disease.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Tigers are an endangered species and therefore understanding their genetic architecture could aid conservation efforts. Here, the authors report the first genome sequence of the Amur tiger and, through close species comparative genomic analysis, provide insight into the genome organization, evolutionary divergence and diversity of big cats.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.