Nature Search

Natural variations at the Stay-Green gene promoter control lifespan and yield in rice cultivars

Breeding crops with delayed senescence could plausibly increase grain yield. Here the authors show that variation at the rice SGR locus contributes to differences in senescence between indica and japonica subspecies and show that introgression can increase yield in an elite indica rice variety.

Dongjin Shin
Sichul Lee
Hong Gil Nam
ResearchOpen Access04 Jun 2020
Nature Communications

Volume: 11, P: 1-11
Author Correction: Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment

Seung-Hun Kang
Wi-jae Lee
Seung Hwan Lee
Amendments and CorrectionsOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1
Clinical utility of genome sequencing in rare diseases: lessons from a single-center study of 1,452 Korean families

Seungbok Lee
Go Hun Seo
Jong-Hee Chae
ResearchOpen Access08 Dec 2025
npj Genomic Medicine

Volume: 11, P: 1-8
Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment

Off-target mutations that occur at a frequency below 0.5% can be difficult to detect. Here the authors use predicted off-target amplification to increase detection sensitivity.

Seung-Hun Kang
Wi-jae Lee
Seung Hwan Lee
ResearchOpen Access17 Jul 2020
Nature Communications

Volume: 11, P: 1-11
Isoniazid resistance without a loss of fitness in Mycobacterium tuberculosis

The treatment ofMycobacterium tuberculosis with drugs such as isoniazid often results in drug resistance, but the mechanisms leading to the resistance are not fully known. In this study, an M. tuberculosisstrain lacking the sigma factor I is shown to be resistant to isoniazid.

Jong-Hee Lee
Nicole C. Ammerman
William R. Bishai
Research20 Mar 2012
Nature Communications

Volume: 3, P: 1-8
Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation

A vesicle trafficking Rab11 effector switch is important for ciliogenesis. Here, the authors report a ciliopathy-related disorder caused by variants in WDR44, a Rab11 effector. WDR44 variants show higher affinity for Rab11 and can impair ciliogenesis.

Andrea Accogli
Saurabh Shakya
Christopher J. Westlake
ResearchOpen Access08 Jan 2024
Nature Communications

Volume: 15, P: 1-20
Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder

GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.

Sukhleen Kour
Deepa S. Rajan
Udai Bhan Pandey
ResearchOpen Access07 May 2021
Nature Communications

Volume: 12, P: 1-15
Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states

Molecular and functional differences between induced pluripotent stem cells (iPSCs) derived from distinct cell types have been described. Here the authors show, by comparing human iPSCs derived from fibroblasts or cord blood, that the competence in activating developmental genes upon differentiation is influenced by the donor cell of origin.

Jong-Hee Lee
Jung Bok Lee
Mickie Bhatia
Research03 Dec 2014
Nature Communications

Volume: 5, P: 1-13
High glycemic albumin representing prestroke glycemic variability is associated with hemorrhagic transformation in patients receiving intravenous thrombolysis

Sang-Hwa Lee
Min Uk Jang
Jong-Hee Sohn
ResearchOpen Access12 Jan 2022
Scientific Reports

Volume: 12, P: 1-8
The Korean Genetic Diagnosis Program for Rare Disease Phase II: outcomes of a 6-year national project

Man Jin Kim
Boram Kim
Moon-Woo Seong
Research06 Jul 2023
European Journal of Human Genetics

Volume: 31, P: 1147-1153
Expanding the clinical and genetic spectrum of GLUL-related developmental and epileptic encephalopathy

Dong Eon Oh
Se Song Jang
Jong-Hee Chae
ResearchOpen Access13 Oct 2025
Scientific Reports

Volume: 15, P: 1-9
Weissella cibaria WIKIM28 ameliorates atopic dermatitis-like skin lesions by inducing tolerogenic dendritic cells and regulatory T cells in BALB/c mice

Seul Ki Lim
Min-Sung Kwon
Hak-Jong Choi
ResearchOpen Access09 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
Differential ferroptosis regulation in red and white gastrocnemius under obesity and its Attenuation by exercise and dietary restriction

Fujue Ji
Haesung Lee
Jong-Hee Kim
ResearchOpen Access03 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Implementing genomic medicine in clinical practice for adults with undiagnosed rare diseases

Jong Hyeon Ahn
Jihoon G. Yoon
Jin Whan Cho
ResearchOpen Access28 Nov 2024
npj Genomic Medicine

Volume: 9, P: 1-12
Loss-of-function gs3 allele decreases methane emissions and increases grain yield in rice

Rice paddies are a source of the potent greenhouse gas methane. The authors demonstrate that a rice variety containing naturally lost function in the gene GS3 has reduced allocation of photosynthates to roots, which results in a reduction of methane emissions during growth.

Youngho Kwon
Ji-Yoon Lee
Choong-Min Ryu
ResearchOpen Access27 Nov 2023
Nature Climate Change

Volume: 13, P: 1329-1333
Diagnostic uplift through the implementation of short tandem repeat analysis using exome sequencing

Jihoon G. Yoon
Seungbok Lee
Jong-Hee Chae
ResearchOpen Access02 Feb 2024
European Journal of Human Genetics

Volume: 32, P: 584-587
Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas

Jae-Hyuk Lee
Seun-Ja Park
Tsung-Teh Wu
Research05 Apr 2004
Oncogene

Volume: 23, P: 4646-4654
Use of in vivo magnetic resonance spectroscopy for studying metabolic diseases

Jong-Hee Hwang
Cheol Soo Choi
ReviewsOpen Access06 Feb 2015
Experimental & Molecular Medicine

Volume: 47, P: e139
Mitochondrial dysfunction by glyoxalase 1 deficiency disrupts definitive endoderm and alveolar development of human pluripotent stem cells

Suji Jeong
Hyebin Koh
Seok-Ho Hong
ResearchOpen Access01 Sept 2025
Experimental & Molecular Medicine

Volume: 57, P: 1940-1950
Exploring gene-phenotype relationships in GRIN-related neurodevelopmental disorders

Jong Ho Cha
Jee Min Kim
Jong-Hee Chae
ResearchOpen Access15 May 2025
npj Genomic Medicine

Volume: 10, P: 1-10
A database of 5305 healthy Korean individuals reveals genetic and clinical implications for an East Asian population

Jeongeun Lee
Jean Lee
Murim Choi
ResearchOpen Access02 Nov 2022
Experimental & Molecular Medicine

Volume: 54, P: 1862-1871
Genomic profiling of 553 uncharacterized neurodevelopment patients reveals a high proportion of recessive pathogenic variant carriers in an outbred population

Youngha Lee
Soojin Park
Jong-Hee Chae
ResearchOpen Access29 Jan 2020
Scientific Reports

Volume: 10, P: 1-11
Ferric citrate and apo-transferrin enable erythroblast maturation with β-globin from hemogenic endothelium

Soo-Been Jeon
Hyebin Koh
Ji Yoon Lee
ResearchOpen Access25 Aug 2023
npj Regenerative Medicine

Volume: 8, P: 1-16
A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

William Bishai and colleagues report that cyclic-di-adenosine monophosphate produced during infection with Mycobacterium tuberculosis induces IFN-β and contributes to the innate sensing of tuberculosis.

Bappaditya Dey
Ruchi Jain Dey
William R Bishai
Research02 Mar 2015
Nature Medicine

Volume: 21, P: 401-406
Pre-stroke glycemic variability estimated by glycated albumin predicts hematoma expansion and poor outcomes in patients with spontaneous intracerebral hemorrhage

Sang-Hwa Lee
Jong-Hee Sohn
Hyuk Jai Choi
ResearchOpen Access08 Aug 2023
Scientific Reports

Volume: 13, P: 1-9
Clinical factors influencing the impact of cluster headache from a prospective multicenter study

Jong-Hee Sohn
Jeong-Wook Park
Soo-Jin Cho
ResearchOpen Access12 Feb 2020
Scientific Reports

Volume: 10, P: 1-7
Terahertz reflectometry imaging for low and high grade gliomas

Young Bin Ji
Seung Jae Oh
Jin-Suck Suh
ResearchOpen Access26 Oct 2016
Scientific Reports

Volume: 6, P: 1-9
A Novel ND3 Mitochondrial DNA Mutation in Three Korean Children With Basal Ganglia Lesions and Complex I Deficiency

Jong Hee Chae
Jin Sook Lee
Michio Hirano
Research01 May 2007
Pediatric Research

Volume: 61, P: 622-624
Cerebellar vermis hypoplasia in CHARGE syndrome: clinical and molecular characterization of 18 unrelated Korean patients

Young Bae Sohn
Jung Min Ko
Kyung-A Lee
Research05 Nov 2015
Journal of Human Genetics

Volume: 61, P: 235-239
Korean Variant Archive (KOVA): a reference database of genetic variations in the Korean population

Sangmoon Lee
Jihae Seo
Murim Choi
ResearchOpen Access27 Jun 2017
Scientific Reports

Volume: 7, P: 1-9
ATP1A3 mutations can cause progressive auditory neuropathy: a new gene of auditory synaptopathy

Kyu-Hee Han
Doo-Yi Oh
Byung Yoon Choi
ResearchOpen Access28 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis

Seon-A Choi
Young-Hyun Kim
Kyu-Tae Chang
ResearchOpen Access21 Nov 2018
Cell Death & Differentiation

Volume: 26, P: 1582-1599
Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache: A Prospective Multicentre Study

Byung-Su Kim
Jeong Wook Park
Soo-Jin Cho
ResearchOpen Access25 Apr 2019
Scientific Reports

Volume: 9, P: 1-8
Identification of 2-hydroxyisocaproic acid production in lactic acid bacteria and evaluation of microbial dynamics during kimchi ripening

Boyeon Park
Hyelyeon Hwang
Jong-Hee Lee
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
Clinical features of cluster headache without cranial autonomic symptoms: results from a prospective multicentre study

Min Kyung Chu
Byung-Su Kim
Soo-Jin Cho
ResearchOpen Access25 Mar 2021
Scientific Reports

Volume: 11, P: 1-9
Characterization of transcriptional response of Lactobacillus plantarum under acidic conditions provides insight into bacterial adaptation in fermentative environments

Sera Jung
Jong-Hee Lee
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Complementation of a mutation in CpSRP43 causing partial truncation of light-harvesting chlorophyll antenna in Chlorella vulgaris

Won-Sub Shin
Bongsoo Lee
Yong Keun Chang
ResearchOpen Access20 Dec 2017
Scientific Reports

Volume: 7, P: 1-11
Socioeconomic factors influencing cosmetic usage patterns

Gyeong-Hun Park
Chanhee Nam
Myung Hwa Kim
Research18 Apr 2018
Journal of Exposure Science & Environmental Epidemiology

Volume: 28, P: 242-250

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