Search

Pretrained using over 100,000 diagnostic histopathological slides across 20 major tissue types, a self-supervised model is shown to outperform existing baselines across various clinically relevant computational pathology tasks.

A van der Waals heterostructure made from atomic layers of ferroelectric CuCrP₂S₆ and ferromagnetic Fe₃GeTe₂ can offer reversible, non-volatile ferroelectric control of two-dimensional magnetism.

It is crucial to avoid crystallization in metallic glasses, which show appealing mechanical properties associated with their amorphous structures. Sohnet al. identify unusual nucleation kinetics in metallic glass nanorods, which exhibits a crystallization temperature minimum at a certain diameter.

Recent studies have shown that the electronic properties of two-dimensional bismuth chalcogenides can be modified by chemical intercalation. Here, Yao et al. demonstrate that the optical transmission in bismuth chacogenide nanoplates can be tuned by intercalation of copper atoms.

Layered black phosphorous has gained significant attention in the 2D materials community, and dynamical control of its bandgap is key to enable novel applications. Here, the authors demonstrate continuous electrical bandgap tuning using moderate displacement fields.

The nanoscale manipulation of the shape and composition of metallic glasses is challenging. Here, the authors employ a multitarget carousel oblique angle deposition strategy to synthesize metallic glass nanoarchitectures, and demonstrate applicability to a range of glass-forming alloys.

The practical performance of lithium–sulphur batteries is lower than expected because of polysulphide dissolution into the electrolyte over time. Sehet al. show that a yolk–shell nanoarchitecture is able to encapsulate sulphur cathode materials efficiently and thus allows over 1,000 charge/discharge cycles.

Free-standing nanoparticle superlattices offer interesting possibilities for the design of devices free from undesired effects of substrates. DNA can now be used to obtain superlattices with control over interparticle spacing, offering an alternative perspective on the synthesis of nanoparticle solids.

Topological materials confined in 1D could transform computing technology, but their crystallization is poorly understood. Here, the authors demonstrate template-based synthesis of 1D nanowires, revealing diameter-dependent phase selectivity.

The axial Higgs mode is theoretically attributed to a hidden ferroaxial component of charge order. In rare-earth tritellurides, this ferroaxial order is now shown to be induced by intertwined orbital and charge orders.

Conventional crystal growth models assume crystals grow into a structure-less liquid, even though liquid metals have shown evidence of structural ordering. Here, the authors show crystal growth can be influenced by the presence of thermodynamically unstable local structural order in the liquid.

FeGe is an antiferromagnetic kagome metal with a rich magnetic and electronic phase diagram. Recently it was found that post-growth annealing of FeGe can suppress or induce charge density wave order depending on the annealing temperature. Here, Klemm, Siddique et al show the critical role that annealing induced Ge-vacancies and stacking faults play in the formation of charge density wave order in FeGe.

Interconnect architectures are vital frameworks that allow disparate components, such as cores and memory, to communicate. This Review provides an overview of the development of key interconnect components, such as metals, diffusion barriers and intermetal dielectrics, and how they can offer more efficient and sustainable performance.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Crystallising a bulk metallic glass usually results in separate phases. Here, the authors use metallic glass nanorods to show that as the sample size approaches the nucleation scale lengths, the crystallization behavior is dictated by the lack of nuclei and nanorods crystallise into a single phase.

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

Multifunctional nanostructures have been created from DNA-based anisotropic, branched and crosslinkable building blocks — ABC monomers. Using these monomers, a target-driven polymerization process is demonstrated where polymers are generated only in the presence of a specific DNA molecule, leading to highly sensitive pathogen detection. The nanoarchitectures can also be used to deliver drugs to cells.

The bulk conductivity of a topological insulator composed of Bi, Sb and Te can be reduced by orders of magnitude by tuning the ratio of Bi to Sb, allowing surface states to dominate conduction.

Resistive switching of 1T-TaS₂ is promising for next-generation electronics. Here, using in operando electron microscopy, the authors determine that Joule heating drives the switching process, which will aid the engineering of future devices.

The layer stacking order in 2D materials can be used to control functional properties. Here, the authors find a thickness effect, where thin flakes of MoTe₂ display stacking arrangements different from bulk crystals.

Detection of an axial Higgs mode by quantum pathway interference reveals an unconventional charge density wave phase in RTe₃.

A molecular catalyst supported on carbon nanotubes efficiently transforms the notorious water pollutant 1,2-dichloroethane into a useful chemical feedstock ethylene in an electrified membrane filtration device.

Circularly polarized light can isolate surface states from bulk states in topological insulators, allowing their unique properties to be probed.

The singular properties of topological insulators are defined by the topological nature of their metallic surface states. This study shows that by doping Bi₂Se₃nanoribbons with antimony, the transport properties of these surface states are measurable and can be distinguished from the contributions due to the bulk of the samples.

The small molecule GS-6207, which disrupts the function of the HIV capsid protein, shows potential as a long-acting therapeutic agent for the treatment and prevention of HIV infection.

Dissolution of sulphur into electrolyte is a major problem in lithium–sulphur batteries. Here, Yao et al.use an indium oxide-carbon interface and a polysulphide catholyte, and show that polysulphides preferentially deposit onto the oxide surface during electrochemical processes, thus alleviating the sulphur loss.

In situ high-resolution electron microscopy reveals that an electrically controlled metal-to-semiconductor phase transition in In₂Se₃ operates by intralayer splitting and interlayer zipping of atomic planes.

The development of therapeutics for central nervous system disorders suffers from high failure rates owing to poor blood–brain barrier penetration and lack of targeted delivery. This Review discusses how nanoparticles can help to overcome these challenges to enable precision targeting of the brain for different central nervous system diseases.

Flexible electronics and other nanoscale devices require simple yet reliable assembly procedures. An optical welding technique for metal nanowires, based on surface plasmon resonances, is now used to fabricate interconnected nanowire networks with enhanced electrical properties for use as transparent electrodes in solar cells and other electrical devices.

Topological nanomaterials exhibit enhanced topological surface states and are thus promising for next-generation electronic devices and quantum computations. This Review discusses synthesis and transport results of topological nanomaterials, with a special focus on 1D topological superconductivity realized using topological insulator nanowires.

In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.