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Covalent inhibitor design confers activity against both GDP- and GTP-bound forms of KRAS G12C

KRAS is an oncogene that switches between a GDP-bound inactive state and a GTP-bound active state. Recently developed KRAS G12C inhibitors are specific to the GDP-bound inactive state. Here, the authors develop a class of covalent KRAS G12C inhibitors capable of targeting both states for the treatment of KRAS-driven cancer.

Matthew L. Condakes
Zhuo Zhang
Michelle L. Stewart
ResearchOpen Access31 Jan 2026
Nature Communications

P: 1-15
Comparison of Plasmid yield between L.B. and using Molasses as a medium

Nitin Sharma
Purshottum Kaushik
ResearchOpen Access28 Oct 2009
Nature Precedings

P: 1
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Impact of the indigenous rotavirus vaccine Rotavac in the Universal Immunization Program in India during 2016–2020

In this multicentered observational study, Rotavac, an indigenous, monovalent, live, attenuated, oral rotavirus vaccine, had an adjusted vaccine efficacy of 54% and protected against severe gastroenteritis in Indian children during its rollout between 2016 and 2020.

Nayana P. Nair
Samarasimha N. Reddy
Mahima Mittal
ResearchOpen Access07 Oct 2025
Nature Medicine

Volume: 31, P: 3871-3878
Immediate Circulatory Response to High Altitude Hypoxia in Man

SUJOY B. ROY
J. S. GULERIA
J. E. WOOD
Research23 Mar 1968
Nature

Volume: 217, P: 1177-1178
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice

Microglia are involved in debris clearance and synaptic pruning, among other processes. However, their direct interaction with the brain vasculature is less clear. Here, the authors show that capillary-associated microglia (CAMs) regulate vascular tone via PANX1-P2RY12 signalling.

Kanchan Bisht
Kenneth A. Okojie
Ukpong B. Eyo
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-13
Feedback Mechanism in Depolarization-Induced Sustained Activation of Extracellular Signal-Regulated Kinase in the Hippocampus

Chinmoyee Maharana
Kaushik P. Sharma
Shiv K. Sharma
ResearchOpen Access22 Jan 2013
Scientific Reports

Volume: 3, P: 1-6
Author Correction: Impact of the indigenous rotavirus vaccine Rotavac in the Universal Immunization Program in India during 2016–2020

Nayana P. Nair
Samarasimha N. Reddy
Mahima Mittal
Amendments and CorrectionsOpen Access27 Oct 2025
Nature Medicine

Volume: 31, P: 3931
Activated protein C promotes human lung cancer progression through the release of tumor extracellular vesicles and transfer of microRNA-200a

Madhura Chatterjee
Deepak Parashar
Kaushik Das
ResearchOpen Access21 Nov 2025
Cell Death & Disease

Volume: 16, P: 1-16
Robust machine learning based Intrusion detection system using simple statistical techniques in feature selection

Sunil Kaushik
Akashdeep Bhardwaj
Habib Hamam
ResearchOpen Access01 Feb 2025
Scientific Reports

Volume: 15, P: 1-20
Low power, non-intrusive 3D localization for underwater mobile robots

Suryansh Sharma and colleagues present Pisces, a system for 3D localization of autonomous underwater mobile robots using blue LED signals and photodiodes. It enhances efficiency and coordination in applications like environmental monitoring and underwater exploration, even in turbid water conditions.

Suryansh Sharma
Daniel Van Passen
Kaushik Chowdhury
ResearchOpen Access23 May 2025
Communications Engineering

Volume: 4, P: 1-12
The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection

NEIL2, a mammalian DNA repair enzyme, has been reported to suppress infection induced inflammation. Here, the authors characterize its role in modulating the severity of SARS-CoV-2 infection.

Nisha Tapryal
Anirban Chakraborty
Tapas K. Hazra
ResearchOpen Access09 Dec 2023
Nature Communications

Volume: 14, P: 1-16
A lightweight network for brain MRI segmentation

Pubali Chatterjee
Amlan Chakrabarti
Kaushik Das Sharma
ResearchOpen Access21 Oct 2025
Scientific Reports

Volume: 15, P: 1-16
Self-Styled ZnO Nanostructures Promotes the Cancer Cell Damage and Supresses the Epithelial Phenotype of Glioblastoma

Rizwan Wahab
Neha Kaushik
Abdulaziz A. Al-Khedhairy
ResearchOpen Access28 Jan 2016
Scientific Reports

Volume: 6, P: 1-13
Machine learning based approach for surface roughness prediction in precision dental prototyping

Anmol Sharma
Ravinder S. Saini
Artak Heboyan
ResearchOpen Access01 Sept 2025
Scientific Reports

Volume: 15, P: 1-16
Structure of the human marker of self 5-transmembrane receptor CD47

CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the molecular mechanism of CD47-mediated signalling.

Gustavo Fenalti
Nicolas Villanueva
Kandasamy Hariharan
ResearchOpen Access01 Sept 2021
Nature Communications

Volume: 12, P: 1-14
Enhanced catalysis through structurally modified hybrid 2-D boron nitride nanosheets comprising of complexed 2-hydroxy-4-methoxybenzophenone motif

Pooja Rana
Ranjana Dixit
Rakesh K. Sharma
ResearchOpen Access24 Dec 2021
Scientific Reports

Volume: 11, P: 1-13
Effect of Azotobacter chroococcum and Rhizophagus irregularis on morphological and biochemical traits of bitter gourd under saline conditions

Priyanka Bijalwan
Alpa Yadav
Ali Khadivi
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Rajiv V. Dave
Baek Kim
Zaid Al-Ishaq
ResearchOpen Access25 Mar 2021
British Journal of Cancer

Volume: 124, P: 1785-1794
Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection

Srijon Kaushik Banerjee
Manish Kumar
Manikuntala Kundu
ResearchOpen Access16 May 2016
Scientific Reports

Volume: 6, P: 1-15
RNA-Seq analysis of human heart tissue reveals SARS-CoV-2 infection and inappropriate activation of the TNF-NF-κB pathway in cardiomyocytes

Kirtan Dave
Mukul Jain
Prashant Kaushik
ResearchOpen Access27 Sept 2024
Scientific Reports

Volume: 14, P: 1-9
Identification of blast resistant finger millet (Eleusine coracana L.) genotype through phenotypic screening and molecular profiling

Isha Ojha
Kamaluddin
Kirtan Dave
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-15
Biosorption of arsenic (III) from aqueous solution using calcium alginate immobilized dead biomass of Acinetobacter sp. strain Sp2b

Renu Khandelwal
Sneha Keelka
Pallavi Kaushik
ResearchOpen Access30 Apr 2024
Scientific Reports

Volume: 14, P: 1-17
Exploring phytochemical composition, photocatalytic, antibacterial, and antifungal efficacies of Au NPs supported by Cymbopogon flexuosus essential oil

Diksha Pathania
Mamta Sharma
Ajit Khosla
ResearchOpen Access22 Aug 2022
Scientific Reports

Volume: 12, P: 1-15
Identification of vaccine targets in pathogens and design of a vaccine using computational approaches

Kamal Rawal
Robin Sinha
Maria Elena Bottazzi
ResearchOpen Access02 Sept 2021
Scientific Reports

Volume: 11, P: 1-25
Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism

Rahul Sharma
Takashi Matsuzaka
Hitoshi Shimano
ResearchOpen Access26 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Haloarchaea Endowed with Phosphorus Solubilization Attribute Implicated in Phosphorus Cycle

Ajar Nath Yadav
Divya Sharma
Anil Kumar Saxena
ResearchOpen Access28 Jul 2015
Scientific Reports

Volume: 5, P: 1-10
Novel biogenic silver nanoconjugates of Abrus precatorius seed extracts and their antiproliferative and antiangiogenic efficacies

Amritpal Kaur
Yash Sharma
Kumud Bala
ResearchOpen Access19 Aug 2023
Scientific Reports

Volume: 13, P: 1-17
Central Glucagon-like Peptide-1 Receptor Signaling via Brainstem Catecholamine Neurons Counteracts Hypertension in Spontaneously Hypertensive Rats

Kenichi Katsurada
Masanori Nakata
Toshihiko Yada
ResearchOpen Access19 Sept 2019
Scientific Reports

Volume: 9, P: 1-13
Two-dimensional transition metal dichalcogenides assisted biofunctionalized optical fiber SPR biosensor for efficient and rapid detection of bovine serum albumin

Siddharth Kaushik
Umesh K. Tiwari
Ravindra K. Sinha
ResearchOpen Access06 May 2019
Scientific Reports

Volume: 9, P: 1-11
Geospatial methodology for determining the regional prevalence of hospital-reported childhood intussusception in patients from India

Shikha Dixit
Manoja Kumar Das
Saurabh Garge
ResearchOpen Access20 Mar 2024
Scientific Reports

Volume: 14, P: 1-10
Essential oil-mediated biocompatible magnesium nanoparticles with enhanced antibacterial, antifungal, and photocatalytic efficacies

Diksha Pathania
Sunil Kumar
Ajit Khosla
ResearchOpen Access06 Jul 2022
Scientific Reports

Volume: 12, P: 1-13
Identification of critical residues in Hepatitis E virus macro domain involved in its interaction with viral methyltransferase and ORF3 proteins

Saumya Anang
Chandru Subramani
Milan Surjit
ResearchOpen Access26 Apr 2016
Scientific Reports

Volume: 6, P: 1-16

Search

Covalent inhibitor design confers activity against both GDP- and GTP-bound forms of KRAS G12C

Comparison of Plasmid yield between L.B. and using Molasses as a medium

A benchmark of expert-level academic questions to assess AI capabilities

Impact of the indigenous rotavirus vaccine Rotavac in the Universal Immunization Program in India during 2016–2020

Immediate Circulatory Response to High Altitude Hypoxia in Man

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice

Feedback Mechanism in Depolarization-Induced Sustained Activation of Extracellular Signal-Regulated Kinase in the Hippocampus

Author Correction: Impact of the indigenous rotavirus vaccine Rotavac in the Universal Immunization Program in India during 2016–2020

Activated protein C promotes human lung cancer progression through the release of tumor extracellular vesicles and transfer of microRNA-200a

Robust machine learning based Intrusion detection system using simple statistical techniques in feature selection

Low power, non-intrusive 3D localization for underwater mobile robots

The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection

A lightweight network for brain MRI segmentation

Self-Styled ZnO Nanostructures Promotes the Cancer Cell Damage and Supresses the Epithelial Phenotype of Glioblastoma

Machine learning based approach for surface roughness prediction in precision dental prototyping

Structure of the human marker of self 5-transmembrane receptor CD47

Enhanced catalysis through structurally modified hybrid 2-D boron nitride nanosheets comprising of complexed 2-hydroxy-4-methoxybenzophenone motif

Effect of Azotobacter chroococcum and Rhizophagus irregularis on morphological and biochemical traits of bitter gourd under saline conditions

Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection

RNA-Seq analysis of human heart tissue reveals SARS-CoV-2 infection and inappropriate activation of the TNF-NF-κB pathway in cardiomyocytes

Identification of blast resistant finger millet (Eleusine coracana L.) genotype through phenotypic screening and molecular profiling

Biosorption of arsenic (III) from aqueous solution using calcium alginate immobilized dead biomass of Acinetobacter sp. strain Sp2b

Exploring phytochemical composition, photocatalytic, antibacterial, and antifungal efficacies of Au NPs supported by Cymbopogon flexuosus essential oil

Identification of vaccine targets in pathogens and design of a vaccine using computational approaches

Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism

Haloarchaea Endowed with Phosphorus Solubilization Attribute Implicated in Phosphorus Cycle

Novel biogenic silver nanoconjugates of Abrus precatorius seed extracts and their antiproliferative and antiangiogenic efficacies

Central Glucagon-like Peptide-1 Receptor Signaling via Brainstem Catecholamine Neurons Counteracts Hypertension in Spontaneously Hypertensive Rats

Two-dimensional transition metal dichalcogenides assisted biofunctionalized optical fiber SPR biosensor for efficient and rapid detection of bovine serum albumin

Geospatial methodology for determining the regional prevalence of hospital-reported childhood intussusception in patients from India

Essential oil-mediated biocompatible magnesium nanoparticles with enhanced antibacterial, antifungal, and photocatalytic efficacies

Identification of critical residues in Hepatitis E virus macro domain involved in its interaction with viral methyltransferase and ORF3 proteins

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