Nature Search

The oldest sepioid cephalopod from the Cretaceous discovered by Digital fossil-mining with zero-shot learning AI

The oldest sepioid in the Cretaceous shows intermediate morphologies between cuttlefish and bobtail squids, revealing their early evolution. This discovery was facilitated by Digital fossil-mining method incorporating a zero-shot learning AI model.

Kanta Sugiura
Shin Ikegami
Yasuhiro Iba
ResearchOpen Access16 Jan 2026
Communications Biology

P: 1-9
Analysis of anticancer drug associated adverse reactions in depressive patients from vigibase

Basile Chretien
Charles Dolladille
Jean-Matthieu L’orphelin
ResearchOpen Access16 Dec 2025
Scientific Reports

Volume: 15, P: 1-11
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L

Shoichi Tani
Masafumi Taniwaki
T. Honjo
Research01 Jan 1999
Journal of Human Genetics

Volume: 44, P: 73-75
Trends in allogeneic hematopoietic cell transplantation survival using population-based descriptive epidemiology method: analysis of national transplant registry data

Yachiyo Kuwatsuka
Hidemi Ito
Keitaro Matsuo
Research19 Jun 2024
Bone Marrow Transplantation

Volume: 59, P: 1295-1301
The prevalence, risk factors, and outcomes of acute pulmonary embolism complicating sepsis and septic shock: a national inpatient sample analysis

Daisuke Hasegawa
Ryota Sato
David Steiger
ResearchOpen Access11 Jul 2024
Scientific Reports

Volume: 14, P: 1-7
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese

Adolescent idiopathic scoliosis (AIS) is a common pediatric disease leading to spinal deformities. Here, the authors report GWAS followed by genome-wide meta-analysis in up to 79,211 Japanese individuals, identifying 20 genetic loci for AIS, 14 of which were previously unreported, and perform in vitro validation for rs1978060.

Ikuyo Kou
Nao Otomo
Shiro Ikegawa
ResearchOpen Access15 Aug 2019
Nature Communications

Volume: 10, P: 1-9
Predictive factors for massive hemorrhage in women with retained products of conception: a prospective study

Reina Sonehara
Tomoko Nakamura
Hiroaki Kajiyama
ResearchOpen Access13 Jul 2022
Scientific Reports

Volume: 12, P: 1-7
Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock

Hiroaki Hiraiwa
Daisuke Kasugai
Toyoaki Murohara
ResearchOpen Access22 Sept 2021
Scientific Reports

Volume: 11, P: 1-9
Relative platelet reductions provide better pathophysiologic signatures of coagulopathies in sepsis

Daisuke Kasugai
Masayuki Ozaki
Naoyuki Matsuda
ResearchOpen Access07 Jul 2021
Scientific Reports

Volume: 11, P: 1-10
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa

Akira Sayo
Shinji Ueno
Hiroko Terasaki
ResearchOpen Access27 Nov 2017
Scientific Reports

Volume: 7, P: 1-8
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Total hydrocortisone dosage in extremely low birth weight infants and neurodevelopment up to school age

Akinobu Taniguchi
Basile Chrétien
Yoshiaki Sato
ResearchOpen Access23 Sept 2025
Pediatric Research

P: 1-7
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
A multiethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis

Kazuki Takeda
Ikuyo Kou
Shiro Ikegawa
Research21 Feb 2019
Journal of Human Genetics

Volume: 64, P: 493-498
A study on the isothermal crystallization of poly(3-methylbutene-1)

We investigated the crystallization dynamics of P3MB1 under isothermal condition by synchrotron radiation X-ray scattering and optical microscopy. At a crystallization temperature (T_c) of 297 °C, needle-like crystals consisting of stacked lamellae formed. As T_c increased, the number of lamellar branches decreased and morphological transition (spherulite → axialite → needle-like crystal) occurred. The suppression of lamellar branching was attributed to the low viscosity of the molten portion at T_c.

Mizuki Kishimoto
Kazuki Mita
Mikihito Takenaka
Research02 Nov 2018
Polymer Journal

Volume: 51, P: 173-182
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

Masato Kasuga and colleagues and Shiro Maeda and colleagues each report the independent identification of SNPs in KCNQ1 associated with type 2 diabetes in the Japanese population. Each group replicated the associations in other populations of East Asian and European descent.

Kazuki Yasuda
Kazuaki Miyake
Masato Kasuga
Research17 Aug 2008
Nature Genetics

Volume: 40, P: 1092-1097
In situ observations of the mesophase formation of isotactic polypropylene—A fast time-resolved X-ray diffraction study

In situ observation of the formation process of mesophase of isotactic polypropylene (iPP) is reported in structural point of view. Combining a rapid temperature jump and a high-flux synchrotron radiation X-ray scattering techniques, very rapid transformation from the molten amorphous state to the mesophase has been observed. The transformation proceeded very quickly in a narrow temperature range accompanied by instantaneous fluctuations in micrometer scale, suggesting the mesophase formation proceeds similarly to spinodal decomposition.

Koji Nishida
Kazuma Okada
Keisuke Kaji
Research23 Nov 2011
Polymer Journal

Volume: 44, P: 95-101
Development of soil-less substrates capable of degrading organic nitrogen into nitrate as in natural soils

Jamjan Meeboon
Ryoya Nishida
Makoto Shinohara
ResearchOpen Access17 Jan 2022
Scientific Reports

Volume: 12, P: 1-10
Validation of an on-chip p16^ink4a/Ki-67 dual immunostaining cervical cytology system using microfluidic device technology

Kei Hashimoto
Tomoo Kumagai
Kazunori Nagasaka
ResearchOpen Access10 Oct 2023
Scientific Reports

Volume: 13, P: 1-10
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
E-Cadherin and Cadherin-Associated Cytoplasmic Proteins Are Expressed in Murine Mast Cells

Tatsuya Tegoshi
Minoru Nishida
Naoki Arizono
Research01 Oct 2000
Laboratory Investigation

Volume: 80, P: 1571-1581
Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing

Shimpei Kubota et al. describe a pipeline for quantitative whole-organ analysis that that combines tissue clearing, 3D imaging, and machine learning for analysis of the tumour microenvironment. The authors apply this in a mouse model of lung tumour and reveal the role of TGF-β in remodelling the cellular microenvironment favouring metastatic invasion.

Shimpei I. Kubota
Kei Takahashi
Kohei Miyazono
ResearchOpen Access05 Mar 2021
Communications Biology

Volume: 4, P: 1-15
A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis

Ikuyo Kou
Kota Watanabe
Shiro Ikegawa
ResearchOpen Access01 Aug 2018
Scientific Reports

Volume: 8, P: 1-8
An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis

Yoji Ogura
Kazuki Takeda
Shiro Ikegawa
ResearchOpen Access16 Mar 2018
Scientific Reports

Volume: 8, P: 1-7
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Yukari Yada
Akihide Ohkuchi
Mariko Hida
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-13

Search

The oldest sepioid cephalopod from the Cretaceous discovered by Digital fossil-mining with zero-shot learning AI

Analysis of anticancer drug associated adverse reactions in depressive patients from vigibase

Blood DNA virome associates with autoimmune diseases and COVID-19

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L

Trends in allogeneic hematopoietic cell transplantation survival using population-based descriptive epidemiology method: analysis of national transplant registry data

The prevalence, risk factors, and outcomes of acute pulmonary embolism complicating sepsis and septic shock: a national inpatient sample analysis

Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese

Predictive factors for massive hemorrhage in women with retained products of conception: a prospective study

Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock

Relative platelet reductions provide better pathophysiologic signatures of coagulopathies in sepsis

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa

A second update on mapping the human genetic architecture of COVID-19

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Total hydrocortisone dosage in extremely low birth weight infants and neurodevelopment up to school age

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

A multiethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis

A study on the isothermal crystallization of poly(3-methylbutene-1)

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

In situ observations of the mesophase formation of isotactic polypropylene—A fast time-resolved X-ray diffraction study

Development of soil-less substrates capable of degrading organic nitrogen into nitrate as in natural soils

Validation of an on-chip p16^ink4a/Ki-67 dual immunostaining cervical cytology system using microfluidic device technology

Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

E-Cadherin and Cadherin-Associated Cytoplasmic Proteins Are Expressed in Murine Mast Cells

Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing

A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis

An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

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