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Showing 51–100 of 141 results

Advanced filters: Author: Kazuki Saito Clear advanced filters

Highlighted Ca²⁺ imaging with a genetically encoded ‘caged’ indicator

Tomoki Matsuda
Kazuki Horikawa
Takeharu Nagai
ResearchOpen Access11 Mar 2013
Scientific Reports

Volume: 3, P: 1-4
A new class of plant lipid is essential for protection against phosphorus depletion

Phosphorus supply is one of the major factors responsible for reduced crop yields. Here Okazaki et al.use untargeted lipidomics to elucidate the biosynthetic pathway of a novel plant lipid, glucuronosyldiacylglycerol, which is essential for the protection of plants against phosphorus depletion.

Yozo Okazaki
Hitomi Otsuki
Kazuki Saito
ResearchOpen Access26 Feb 2013
Nature Communications

Volume: 4, P: 1-10
Impact of the plastidial stringent response in plant growth and stress responses

The ppGpp-dependent control of cell activities, namely the stringent response, has been elusive in eukaryotes. Arabidopsis mutant analysis now shows that plant stringent response controls organelle function and contributes to systematic growth.

Mikika Maekawa
Rina Honoki
Shinji Masuda
Research09 Nov 2015
Nature Plants

Volume: 1, P: 1-7
Characterization of a recently evolved flavonol-phenylacyltransferase gene provides signatures of natural light selection in Brassicaceae

Protection from UV-B is critical for land plant survival. Here Tohge et al. show that saiginols, a novel class of flavonols that efficiently absorb UV-B, accumulate in Arabidopsisaccessions collected from high irradiance regions and identify a flavonol phenylacyltransferase gene required for saiginol production.

Takayuki Tohge
Regina Wendenburg
Alisdair R. Fernie
ResearchOpen Access22 Aug 2016
Nature Communications

Volume: 7, P: 1-11
K-Ras is essential for the development of the mouse embryo

Keiko Koera
Kenji Nakamura
Motoya Katsuki
Research04 Sept 1997
Oncogene

Volume: 15, P: 1151-1159
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Structural characterization of mutant α-galactosidases causing Fabry disease

Kanako Sugawara
Kazuki Ohno
Hitoshi Sakuraba
Research01 Sept 2008
Journal of Human Genetics

Volume: 53, P: 812-824
Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia

Cancer cachexia is a multifactorial metabolic syndrome affecting a large fraction of patients with advanced cancer. Here the authors report a decrease in B vitamin-related liver enzymes in mouse models and gastric cancer patients with cachexia.

Yasushi Kojima
Emi Mishiro-Sato
Masahiro Aoki
ResearchOpen Access06 Oct 2023
Nature Communications

Volume: 14, P: 1-23
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Soichi Ogishima
Satoshi Nagaie
Masayuki Yamamoto
ResearchOpen Access10 Dec 2021
Human Genome Variation

Volume: 8, P: 1-8
A proposed framework for the description of plant metabolomics experiments and their results

Helen Jenkins
Nigel Hardy
Douglas B Kell
Reviews06 Dec 2004
Nature Biotechnology

Volume: 22, P: 1601-1606
Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion

Appropriate processing of value information is essential for survival. Here the authors show that in mice, serotonergic activations originating from the median raphe nucleus facilitated aversion in a pathway-dependent manner, while silencing this pathway was rewarding.

Hiroyuki Kawai
Youcef Bouchekioua
Shuji Kaneko
ResearchOpen Access22 Dec 2022
Nature Communications

Volume: 13, P: 1-22
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

The solute carrier transporter protein SLC25A44 regulates uptake of branched-chain amino acids in mitochondria of brown adipose tissue in which they are utilized for thermogenesis.

Takeshi Yoneshiro
Qiang Wang
Shingo Kajimura
Research21 Aug 2019
Nature

Volume: 572, P: 614-619
RETRACTED ARTICLE: Sulfur availability regulates plant growth via glucose-TOR signaling

Plants lack the amino acid sensors that regulate TOR in metazoans. Here Dong et al. show that Arabidopsis GCN2 senses carbon and nitrogen availability for cysteine synthesis while sulfur limitation activates TOR via glucose metabolism, providing a mechanism whereby plants control growth according to nutrient availability.

Yihan Dong
Marleen Silbermann
Markus Wirtz
ResearchOpen Access27 Oct 2017
Nature Communications

Volume: 8, P: 1-10
Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis

Kosuke Saito
Takashi Uebanso
Yoshiro Saito
ResearchOpen Access20 Aug 2015
Scientific Reports

Volume: 5, P: 1-11
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells

Kenji Tanigaki
Hua Han
Tasuku Honjo
Research22 Apr 2002
Nature Immunology

Volume: 3, P: 443-450
Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer

Shu Yazaki
Rui Kitadai
Kouya Shiraishi
ResearchOpen Access28 Nov 2025
npj Breast Cancer

Volume: 11, P: 1-11
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Database of the clinical phenotypes, genotypes and mutant arylsulfatase B structures in mucopolysaccharidosis type VI

Seiji Saito
Kazuki Ohno
Hitoshi Sakuraba
Research16 Feb 2012
Journal of Human Genetics

Volume: 57, P: 280-282
A SNP in the ABCC11 gene is the determinant of human earwax type

Koh-ichiro Yoshiura
Akira Kinoshita
Norio Niikawa
Research29 Jan 2006
Nature Genetics

Volume: 38, P: 324-330
Self-referential judgments from the same personality trait scales show increased representational similarity in mPFC

Self-report questionnaires are vital in psychology, yet how the brain generates these responses is unknown. We found that items assessing the same trait produced similar activation patterns specifically in the medial prefrontal cortex (mPFC).

Keise Izuma
Ayahito Ito
Ryuta Aoki
ResearchOpen Access20 Dec 2025
Communications Psychology

Volume: 3, P: 1-12
Publisher Correction: Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

Ryoei Uchida
Yoshimasa Saito
Hidetsugu Saito
Amendments and CorrectionsOpen Access07 Mar 2019
npj Aging and Mechanisms of Disease

Volume: 5, P: 1
Efficient marmoset genome engineering by autologous embryo transfer and CRISPR/Cas9 technology

Yukiko Abe
Harumi Nakao
Atsu Aiba
ResearchOpen Access12 Oct 2021
Scientific Reports

Volume: 11, P: 1-8
Ovariectomy attenuates phenotypes related to Alzheimer’s disease in a preclinical mouse model and in C57BL/6 J mice

Kazuki Fujii
Yumie Koshidaka
Keizo Takao
ResearchOpen Access28 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
Pressure accelerates the circadian clock of cyanobacteria

Ryo Kitahara
Katsuaki Oyama
Kazuki Terauchi
ResearchOpen Access27 Aug 2019
Scientific Reports

Volume: 9, P: 1-8
A lipidome atlas in MS-DIAL 4

Mass spectral fragmentations of lipids across 117 lipid subclasses are presented in a lipidome atlas.

Hiroshi Tsugawa
Kazutaka Ikeda
Makoto Arita
Research15 Jun 2020
Nature Biotechnology

Volume: 38, P: 1159-1163
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Treatment strategy changes for inflammatory bowel diseases in biologic era: results from a multicenter cohort in Japan, Far East 1000

Takashi Taida
Yuki Ohta
Naoya Kato
ResearchOpen Access21 Aug 2023
Scientific Reports

Volume: 13, P: 1-11
Acetate-mediated novel survival strategy against drought in plants

In response to drought, acetate accumulates endogenously through redirection of metabolic fluxes, and stimulates jasmonate pathways controlling Arabidopsis drought tolerance. Application of exogenous acetic acid alone increases drought tolerance of major crops such as maize, wheat and rice.

Jong-Myong Kim
Taiko Kim To
Motoaki Seki
Research26 Jun 2017
Nature Plants

Volume: 3, P: 1-7
Probable detection of an eruptive filament from a superflare on a solar-type star

An energetic eruptive filament on EK Draconis most probably launched a coronal mass ejection with a mass ten times larger than the largest solar coronal mass ejection. Studying such ejections provides insight into stellar angular momentum loss and the habitability of orbiting planets.

Kosuke Namekata
Hiroyuki Maehara
Kazunari Shibata
ResearchOpen Access09 Dec 2021
Nature Astronomy

Volume: 6, P: 241-248
Electrocardiographic abnormalities and home blood pressure in treated elderly hypertensive patients: Japan home versus office blood pressure measurement evaluation in the elderly (J-HOME-Elderly) study

Taku Shibamiya
Taku Obara
Yutaka Imai
Research30 Apr 2010
Hypertension Research

Volume: 33, P: 670-677
Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

Ryoei Uchida
Yoshimasa Saito
Hidetsugu Saito
ResearchOpen Access01 Dec 2018
npj Aging and Mechanisms of Disease

Volume: 4, P: 1-9
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

Toshimasa Yamauchi and colleagues report results of a genome-wide association study of type 2 diabetes in the Japanese population. They identify new risk loci at UBE2E2 and C2CD4A-C2CD4B and show that the latter is also associated with type 2 diabetes risk in Europeans.

Toshimasa Yamauchi
Kazuo Hara
Takashi Kadowaki
Research05 Sept 2010
Nature Genetics

Volume: 42, P: 864-868
Copy-number variations in Y-chromosomal azoospermia factor regions identified by multiplex ligation-dependent probe amplification

Kazuki Saito
Mami Miyado
Maki Fukami
Research08 Jan 2015
Journal of Human Genetics

Volume: 60, P: 127-131
Landscape of the lipidome and transcriptome under heat stress in Arabidopsis thaliana

Yasuhiro Higashi
Yozo Okazaki
Kazuki Saito
ResearchOpen Access27 May 2015
Scientific Reports

Volume: 5, P: 1-11
PARP inhibitors elicit a cellular senescence mediated inflammatory response in homologous recombination proficient cancer cells

Misato Kamii
Ryo Kamata
Akihiro Ohashi
ResearchOpen Access02 May 2025
Scientific Reports

Volume: 15, P: 1-12
Reevaluating the therapeutic role of extended lymph node dissection in the era of robot-assisted radical prostatectomy

Atsuro Sawada
Koshiro Nishimoto
Takahiro Inoue
ResearchOpen Access21 May 2025
Scientific Reports

Volume: 15, P: 1-13
Detection of Fine Radiographic Progression in Finger Joint Space Narrowing Beyond Human Eyes: Phantom Experiment and Clinical Study with Rheumatoid Arthritis Patients

Kazuki Kato
Nobutoshi Yasojima
Tamotsu Kamishima
ResearchOpen Access12 Jun 2019
Scientific Reports

Volume: 9, P: 1-10
Neonatal outcomes following different ovarian stimulation protocols in fresh single embryo transfer

Seung Chik Jwa
Akira Nakashima
Hidekazu Saito
ResearchOpen Access28 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

This Perspective, from a large group of metabolomics experts, provides best practices and simplified reporting guidelines for practitioners of liquid chromatography– and gas chromatography–mass spectrometry-based metabolomics.

Saleh Alseekh
Asaph Aharoni
Alisdair R. Fernie
Reviews08 Jul 2021
Nature Methods

Volume: 18, P: 747-756
Molecular picture of fluoropolymer adsorption on nanocarbon materials

Composites of fluoropolymer (FKM) and nano-carbon fillers have been considered as sealing materials for hydrogen fuel storage. We here characterize, structurally and dynamically, FKM chains adsorbed on single-walled carbon nanotubes (SWCNTs) and carbon black (CB), which were prepared by a solvent leaching method.

Daisuke Kawaguchi
Kazuki Sasahara
Keiji Tanaka
Research21 Jul 2021
Polymer Journal

Volume: 53, P: 1469-1473
Adipose-derived stem cells using fibrin gel as a scaffold enhances post-hepatectomy liver regeneration

Hiroki Imamura
Yoshito Tomimaru
Hidetoshi Eguchi
ResearchOpen Access21 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Evaluating responses by ChatGPT to farmers’ questions on irrigated lowland rice cultivation in Nigeria

Ali Ibrahim
Kalimuthu Senthilkumar
Kazuki Saito
ResearchOpen Access10 Feb 2024
Scientific Reports

Volume: 14, P: 1-8
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts

Allogenic induced pluripotent stem cell-derived cardiomyocytes transplanted directly into infarcted cynomolgus monkey hearts show electrical coupling with host cardiomyocytes improve cardiac contractile function after mild immunosuppression.

Yuji Shiba
Toshihito Gomibuchi
Uichi Ikeda
Research10 Oct 2016
Nature

Volume: 538, P: 388-391
Species-independent analytical tools for next-generation agriculture

This perspective highlights the new species-independent analytical tools with a focus on plant nanosensors and portable Raman spectroscopy, and evaluates their applications in agriculture, such as detecting plant stresses and monitoring crop physiology.

Tedrick Thomas Salim Lew
Rajani Sarojam
Michael S. Strano
Reviews30 Nov 2020
Nature Plants

Volume: 6, P: 1408-1417
Preparation and water desalination properties of bridged polysilsesquioxane membranes with divinylbenzene and divinylpyridine units

Bridged polysilsesquioxanes are promising materials for reverse osmosis membranes because they exhibit robust properties. To investigate the effects of the polarity and rigidity of organic components of the polymer on the water permeability of the membrane, two alkoxysilane monomers, 2,5-bis[2-(triethoxysilyl)vinyl]pyridine (BTES-VP) and 1,4-bis[2-(triethoxysilyl)vinyl]benzene (BTES-VB), were synthesized. Both membranes prepared from BTES-VP and BTES-VB rejected 95–97% of aqueous sodium chloride and displayed water permeances of 1.1 × 10⁻¹³ and 8.5 × 10⁻¹⁴ m³/(m²· Pa· s), respectively.

Kazuki Yamamoto
Ibuki Saito
Takahiro Gunji
Research27 Jul 2020
Polymer Journal

Volume: 52, P: 1367-1374
The strength of confidence is involved in controlling the intensity of attentional allocation

Kazuki Yoshida
Ryuji Saito
ResearchOpen Access21 Jan 2025
Scientific Reports

Volume: 15, P: 1-9
Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia

Ayako Nishizawa
Kazuki Kumada
Junichi Sugawara
ResearchOpen Access18 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
Chaperone therapy for Krabbe disease: potential for late-onset GALC mutations

Mohammad Arif Hossain
Katsumi Higaki
Norio Sakai
Research25 Jun 2015
Journal of Human Genetics

Volume: 60, P: 539-545
RiceAtlas, a spatial database of global rice calendars and production

Alice G. Laborte
Mary Anne Gutierrez
Andrew Nelson
ResearchOpen Access30 May 2017
Scientific Data

Volume: 4, P: 1-10
Structural study on mutant α-l-iduronidases: insight into mucopolysaccharidosis type I

Kanako Sugawara
Seiji Saito
Hitoshi Sakuraba
Research01 May 2008
Journal of Human Genetics

Volume: 53, P: 467-474

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