Nature Search

Programmable divergent electrochemical ring-opening multifunctionalization of strained rings

The ring-opening functionalization of strained rings represents a highly valuable transformation, but existing strategies predominantly focus on ring-opening difunctionalization. Now a multisite, programmable, divergent ring-opening functionalization of strained rings via the electro-oxidation of continuous C–C bond and multiple C(sp³)–H bonds has been developed.

Yajuan Li
Yatao Lang
Tao Shen
Research02 Apr 2026
Nature Chemistry

Volume: 18, P: 656-668
Improving seasonal prediction of global mean surface temperature by incorporating dynamic ENSO realistic forecasts

Ke-Xin Li
Fei Zheng
ResearchOpen Access24 Mar 2026
npj Climate and Atmospheric Science

P: 1-8
Maintaining sulfur supply to the symbiosome delays nodule senescence in soybean

Li et al. demonstrate that SULTR-mediated sulfur input is a pivotal step in regulating nodule senescence, and provide insights for developing strategies to enhance symbiotic nitrogen fixation in legumes by delaying nodule senescence.

Yuan Li
Miao-Miao Nie
Zhi-Chang Chen
ResearchOpen Access04 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Fangchinoline restores TFEB-driven lysosomal biogenesis and blocks H1N1 infection

Cui-qin Cheng
Fang Xie
Xin Jia
Research02 Apr 2026
Acta Pharmacologica Sinica

P: 1-13
Suppressing ASPARTIC PROTEASE 1 prolongs photosynthesis and increases wheat grain weight

Suppressing wheat ASPARTIC PROTEASE 1 promotes the homeostasis of PsbO, stabilizes the photosystem complex and elongates the duration of active photosynthesis, leading to increases in the CO₂ assimilation rate, kernel weight and yield.

Ke-Xin Niu
Chao-Yan Chang
Jin-Ying Gou
Research05 Jun 2023
Nature Plants

Volume: 9, P: 965-977
Effects of various static calibration postures on knee mechanics during locomotor tasks using statistical parametric mapping analysis

Yu-ting Zhao
Xia Wang
Zhi-peng Zhou
ResearchOpen Access14 Aug 2025
Scientific Reports

Volume: 15, P: 1-9
Publisher Correction: Cannabinoid CB₁ receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior

Chen-Jie Shen
Di Zheng
Xiao-Ming Li
Amendments and Corrections30 Jan 2019
Nature Medicine

Volume: 25, P: 350
Conjunctive encoding of exploratory intentions and spatial information in the hippocampus

The hippocampus maps space, but its role in encoding investigatory intentions is unclear. Here the authors show that certain CA1 neurons encode both spatial information and animals’ intention to explore, depending on input from lateral entorhinal cortex.

Yi-Fan Zeng
Ke-Xin Yang
Ning Zhou
ResearchOpen Access15 Apr 2024
Nature Communications

Volume: 15, P: 1-16
Pharmacokinetics and dopamine/acetylcholine releasing effects of ginsenoside Re in hippocampus and mPFC of freely moving rats

Jing Shi
Wei Xue
Ke-xin Li
Research03 Dec 2012
Acta Pharmacologica Sinica

Volume: 34, P: 214-220
Roboticized AI-assisted microfluidic photocatalytic synthesis and screening up to 10,000 reactions per day

The current throughput of conventional organic chemical synthesis is usually a few experiments for each operator per day. Here the authors develop a robotic system for ultra-high-throughput chemical synthesis, online characterization and large-scale condition screening of photocatalytic reactions.

Jia-Min Lu
Hui-Feng Wang
Qun Fang
ResearchOpen Access12 Oct 2024
Nature Communications

Volume: 15, P: 1-13
Increased NRG1-ErbB4 signaling in human symptomatic epilepsy

Jun-Ming Zhu
Ke-Xin Li
Xiao-Ming Li
ResearchOpen Access10 Mar 2017
Scientific Reports

Volume: 7, P: 1-7
Cannabinoid CB₁ receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior

Activating cannabinoid receptors in a newly identified neural circuit ameliorates depressive-like behaviors in mice.

Chen-Jie Shen
Di Zheng
Xiao-Ming Li
Research14 Jan 2019
Nature Medicine

Volume: 25, P: 337-349
Ideal nodal rings of one-dimensional photonic crystals in the visible region

Wei-Min Deng
Ze-Ming Chen
Jian-Wen Dong
ResearchOpen Access12 May 2022
Light: Science & Applications

Volume: 11, P: 1-8
Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4

Li Jiang
Si-Cheng Liang
Xiao-Chi Ma
ResearchOpen Access17 Apr 2015
Scientific Reports

Volume: 5, P: 1-7
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates

Jing-hong Chen
Ke-xin Li
Peng Luo
ResearchOpen Access15 Apr 2025
Acta Pharmacologica Sinica

Volume: 46, P: 2547-2563
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy

In mouse models, the authors find that NRG1–ErbB4 signaling contributes to epilepsy through regulating the excitability of fast-spiking parvalbumin interneurons. ErbB4 expression was also reduced in human epileptogenic tissue.

Ke-Xin Li
Ying-Mei Lu
Xiao-Ming Li
Research11 Dec 2011
Nature Neuroscience

Volume: 15, P: 267-273
Aging-related aneuploidy is associated with mitochondrial imbalance and failure of spindle assembly

Fa-Li Zhang
Wei-Dong Li
Wei Shen
ResearchOpen Access08 Jul 2023
Cell Death Discovery

Volume: 9, P: 1-12
Tumor-derived lactate fuels the STAT3-LCN2 pathway to promote bladder cancer malignancy and chemoresistance

Shih-Yu Yu
Hao-Yi Li
Yu-Cheng Lee
ResearchOpen Access24 Nov 2025
Scientific Reports

Volume: 15, P: 1-16
Uncovering the anticancer mechanism of Compound Kushen Injection against HCC by integrating quantitative analysis, network analysis and experimental validation

Li Gao
Ke-xin Wang
Guan-hua Du
ResearchOpen Access12 Jan 2018
Scientific Reports

Volume: 8, P: 1-15
Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia

Shu-qing Chu
Yi-jie Chen
Su-lin Zhang
Research01 Oct 2025
Acta Pharmacologica Sinica

Volume: 47, P: 504-517
The association between triglyceride–glucose index and the recurrence of myocardial infarction in young patients with previous coronary heart disease

Xue-Yao Yang
Ke Li
Hui-Juan Zuo
ResearchOpen Access26 Aug 2025
Scientific Reports

Volume: 15, P: 1-10
Estrogen-dependent depressor response of melatonin via baroreflex afferent function and intensification of PKC-mediated Na_v1.9 activation

Di Wu
Dan Zhao
Bai-yan Li
Research07 Feb 2022
Acta Pharmacologica Sinica

Volume: 43, P: 2313-2324
The baroreflex afferent pathway plays a critical role in H₂S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions

Ying Li
Yan Feng
Bai-yan Li
Research05 Nov 2020
Acta Pharmacologica Sinica

Volume: 42, P: 898-908
Internet addiction and its association with quality of life in patients with major depressive disorder: a network perspective

Wei Bai
Hong Cai
Yu-Tao Xiang
ResearchOpen Access04 Apr 2022
Translational Psychiatry

Volume: 12, P: 1-7
Advancing annual global mean surface temperature prediction to 2 months lead using physics based strategy

Ke-Xin Li
Fei Zheng
Noel Keenlyside
ResearchOpen Access19 Sept 2024
npj Climate and Atmospheric Science

Volume: 7, P: 1-11
Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells

Yi Liu
Ke-xin Zhu
Fa-jun Nan
Research16 Jan 2020
Acta Pharmacologica Sinica

Volume: 41, P: 813-824
Advances in cannabinoid receptors pharmacology: from receptor structural insights to ligand discovery

Si-yuan Shen
Chao Wu
Wei Yan
Reviews05 Feb 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1495-1510
The crosstalk between endothelial cells and vascular smooth muscle cells aggravates high phosphorus-induced arterial calcification

Xiao Lin
Su-Kang Shan
Ling-Qing Yuan
ResearchOpen Access26 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-15
Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice

Yan-yan Yu
Shi-chao Cui
Jing-ya Li
Research22 Jul 2020
Acta Pharmacologica Sinica

Volume: 42, P: 272-281
Single cell epigenomic and transcriptomic analysis uncovers potential transcription factors regulating mitotic/meiotic switch

Fa-Li Zhang
Yan-Qin Feng
Wei Shen
ResearchOpen Access17 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-12
Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea

Lin Yang
Jing Zhao
Jing Ai
Research20 Dec 2019
Acta Pharmacologica Sinica

Volume: 41, P: 620-628
Stretchable and self-healable spoof plasmonic meta-waveguide for wearable wireless communication system

A novel stretchable spoof plasmonic meta-waveguide with excellent stability, superior durability, and self-healing ability is achieved, which could ensure reliable microwave transmission in future flexible wireless communication systems.

Bu-Yun Yu
De-Wei Yue
Quan Li
ResearchOpen Access25 Oct 2022
Light: Science & Applications

Volume: 11, P: 1-13
Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation

Zheng-xia Zha
Yu Lin
Yan-li Liu
Research22 Jun 2022
Acta Pharmacologica Sinica

Volume: 44, P: 105-119
An enhanced deep learning method for the quantification of epicardial adipose tissue

Ke-Xin Tang
Xiao-Bo Liao
Jun Liu
ResearchOpen Access23 Oct 2024
Scientific Reports

Volume: 14, P: 1-14
Schisandrin B, a dual positive allosteric modulator of GABA_A and glycine receptors, alleviates seizures in multiple mouse models

Jun Wu
Miao Zhao
Hai-bo Yu
Research28 Nov 2023
Acta Pharmacologica Sinica

Volume: 45, P: 465-479
A fault diagnosis method for wireless sensor network nodes based on a belief rule base with adaptive attribute weights

Ke-Xin Shi
Shi-Ming Li
Wei He
ResearchOpen Access19 Feb 2024
Scientific Reports

Volume: 14, P: 1-20
Horizontally forced initiation of the Izu-Bonin-Mariana subduction zone

A three-stage process of contraction, rifting and final maturation best explains subduction zone initiation in Izu-Bonin-Mariana-type systems, according to numerical and geochemical modelling informed by existing geochemical and petrological data.

Liang Liu
Hong-Yan Li
Yi-Gang Xu
ResearchOpen Access20 Feb 2024
Communications Earth & Environment

Volume: 5, P: 1-11
Suicidality in clinically stable bipolar disorder and schizophrenia patients during the COVID-19 pandemic

Yu-Chen Li
Wei Bai
Yu-Tao Xiang
ResearchOpen Access29 Jul 2022
Translational Psychiatry

Volume: 12, P: 1-7
Molecular targets of Chinese herbs: a clinical study of hepatoma based on network pharmacology

Li Gao
Xiao-dong Wang
Xiong-zhi Wu
ResearchOpen Access04 May 2016
Scientific Reports

Volume: 6, P: 1-11
Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites

Ling-lei Kong
Li Gao
Guan-hua Du
Research15 Apr 2021
Acta Pharmacologica Sinica

Volume: 42, P: 1223-1234
Association between per- and polyfluoroalkyl substances exposure and risk of diabetes: a systematic review and meta-analysis

Si-Yu Gui
Jian-Chao Qiao
Cheng-Yang Hu
Reviews15 Aug 2022
Journal of Exposure Science & Environmental Epidemiology

Volume: 33, P: 40-55

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