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Electron-electron interactions in many-body systems may manifest themselves through the fractional quantum Hall effect. Here, the authors perform transport measurements in bilayer graphene, and observe particle-hole symmetric fractional quantum Hall states in theN=2 Landau level.

EGFR inhibitors are standard of care in patients with EGFR-mutant non-small cell lung cancer (NSCLC) but resistance often develops. Here the authors report that the evolution of EGFR inhibitor resistance in EGFR-mutant NSCLC results in a sensitivity to the compound, MCB-613, and investigate the underlying mechanism of action.

A unidirectional magnetoresistance observed in bilayer metal films could be used to add directional sensitivity to conventional magnetic sensors based on anisotropic magnetoresistance.

Orbital angular momentum transfer from optical vortex beams to electronic quantum Hall states is reported in a graphene sheet, showing a robust contribution to the radial photocurrent that depends on the vorticity of light.

Guided by density functional theory, a commercially viable refractory alloy is developed, which exhibits excellent room-temperature ductility and strength, and high strength at elevated temperatures.

Spins are transmitted over a distance of 5 μm through a piece of antiferromagnetic graphene. This shows that graphene can be a platform to explore the fundamental physics of spin transport in antiferromagnets for application in spintronics.

Spin–orbit torques in heavy metal/ferromagnetic layers have a complex dependence on the magnetization direction. This dependence can be exploited to increase the efficiency of spin–orbit torques.

Arctic marine ecosystems have experienced significant change through the Holocene. Here, the authors used sedaDNA from Northern Greenland to reconstruct marine mammal occurrence, demonstrating the impact of air temperature and sea ice cover over the past 12000 years.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

The combination of modular tangible interfaces and constrained optimization control enables users to operate shape-changing robots by matching their morphology and ensuring safety, allowing adaptation to different environments and application areas.

Here the authors report the synthesis of defect-rich boron nitride by flux reconstruction method, which exhibited good reactivity for semihydrogenation of low concentration acetylene in ethylene-abundant gas stream.

Strong electron–electron interactions in magic-angle twisted bilayer graphene can fundamentally change the topology of the system’s flat bands, producing a hierarchy of strongly correlated topological insulators in modest magnetic fields.

A 2D topological charge pump in a photonic waveguide array is used to observe boundary physics associated with the 4D quantum Hall effect experimentally.

A central goal of spintronics is electric control of magnetism. One particularly promising method makes use of spin-orbit torques which arise due to the combination of electric current, and the intrinsic spin-orbit effect in a material. Here, Grezes et al demonstrate non-volatile electrical control of the spin-orbit torque generated at the interface between an oxide and a metal.

A free-living trial in people with overweight or obesity found that minimally processed diets led to greater weight loss and cardiometabolic improvements than ultraprocessed diets following UK healthy eating guidelines at 8 weeks.

Strongly coupled light–matter systems could offer enhanced manipulation of topological phenomena. Now, tunable non-Hermitian effects are demonstrated with exciton–polaritons induced by a twist degree of freedom.

A room-temperature double-layer WS₂ microcavity is used to explore spin anisotropy and tune it with interlayer spacing.

Here authors show loss of AKAP11, a strong genetic risk factor for bipolar disorder and schizophrenia, disrupts PKA proteostasis and signaling, leading to widespread transcriptomic alterations across the brain, particularly in striatal neurons, as well as altered behavior.

Submarine glacial landforms are used to reconstruct the Holocene retreat dynamics and stability of Petermann Glacier in northwest Greenland. Here, a large grounding-zone wedge at the mouth of Petermann fjord indicates a period of glacier stability, with final retreat likely driven by marine ice cliff instability.

High-resolution STM/STS visualizes the fractionalization of flat moiré bands into discrete Hofstadter subbands in moiré graphene near the predicted second magic angle, and experimentally establishes several fundamental properties of the fractal Hofstadter energy spectrum.

The authors study a disordered β-Ta film, finding that quasiparticle recombination is governed by the phonon scattering time, which is faster than conventional recombination in ordered superconductors. The authors interpret the results in terms of quasiparticle localization, which helps to understand the quasiparticle relaxation in disordered superconducting circuits.

Time-resolved X-ray microscopy reveals the mechanism and speed of current-induced magnetization switching of Co/Pt dots under the combined effect of spin-orbit torques and Dzyaloshinskii–Moriya interaction.

Dynamic control of light flow in 2D synthetic landscapes is emerging as a valuable tool for the development of light-based technologies. Here the authors harness time-dependent non-Hermitian Hamiltonians to demonstrate dynamic control over the skin effect.

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

An electric field is shown to induce an in-plane effective magnetic field enabling the deterministic magnetization switching of a magnetic multilayer on a piezoelectric substrate.

Bird song is commonly seen as a male trait that plays a role in female attraction, but its origin and prevalence in females are unknown. Here, Odom et al.show that female song is widespread and that it was present in the common ancestor of modern songbirds.

In this study, the authors generated iPSC lines from more than 100 sporadic ALS cases, which recapitulated key disease phenotypes and enabled large-scale drug screening, identifying a promising combination therapy of baricitinib, memantine and riluzole.

Despite their name, the bulk electrical conductivity of most topological insulators is relatively high, masking many of the important characteristics of its protected, surface conducting states. Counter-doping reduces the bulk conductivity of Bi₂Se₃ significantly, allowing these surface states and their properties to be clearly identified.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

A complete physical map of the region encompassing the locus for hereditary breast and ovarian cancer should assist the long-awaited cloning of this important gene.

Magnetic anisotropy in mixed rare earth iron garnet films is shown to originate from the atomic ordering of the rare earth cations during growth of the film. Cation ordering on inequivalent sites provides a powerful strategy to engineer the magnetic properties of complex oxides.

Electrically switching perpendicular magnetized ferromagnets using spin-orbit torques without assisting magnetic fields is a major goal for spintronics. Recently, several works have proposed using out-of-plane spin polarized currents to achieve this, but these rely on antiferromagnetic metals with low Neel temperatures. Here, Wang et al show that such out-of-plane spin polarization driven switching can be achieved using the interface of an antiferromagnetic insulator and a heavy metal.

Real-space mapping of the quantum Hall state at the Dirac point in epitaxial graphene reveals unexpected localized lifting of the degeneracy of this level. This could be the result of moiré interference caused by the twisting of the top layer with respect to underlying layers, suggesting possible new ways to understand and control the unusual properties of graphene.

The influence of mRNA splicing on colon cancer development and progression is unclear. In this study, the authors demonstrate that the SRSF1 splicing factor is essential to sustain the stem cell phenotype of WNT-activated colorectal cancers.

Kevin Boehnke and Richard E. Harris introduced a course in meditation, yoga and mindfulness to the neuroscience programme at their institution.

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

Lattice distortions induced by ripples in two-dimensional molybdenum disulfide can reduce electron–phonon scattering, leading to improved charge carrier mobility and enhanced transistor performance.

Quantum computers may help to solve classically intractable problems, such as simulating non-equilibrium dissipative quantum systems. The critical dynamics of a dissipative quantum model has now been probed on a trapped-ion quantum computer.

Different models exist to characterize magnetic reconnection, a process that converts magnetic energy into plasma thermal and kinetic energy, but a quantitative theoretical predictive model of how rapidly it proceeds has been lacking. Here, a self-consistent theory of the reconnection rate derived from first principles, and confirmed with numerical simulations, provides a new understanding of reconnection in solar flares and geomagnetic substorms.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.