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Genome-wide association and fine-mapping analyses in approximately 260,000 Japanese individuals combined with a newly constructed Japanese-specific genotype reference panel identify hundreds of new loci and putative causal variants for 63 quantitative traits.

Here, the authors develop a water-resistant redox-active metal–organic framework (RAMOF) featuring charge storage capability in aqueous electrolytes, and demonstrate an aqueous RAMOF–air rechargeable battery and material recyclability of the RAMOF.

This study reveals that jellyfish swimming can be guided and predicted using electrical stimulation and machine learning, illustrating how embodied intelligence shapes both spontaneous and stimulus-evoked behaviors.

Resistance to ALK inhibitors such as lorlatinib often arise due to on-target mutations. Here, the authors show the multi-kinase inhibitor gilteritinib is effective against different mutations that arise during lorlatinib in ALK fusion positive lung cancer to cause resistance.

Effective antivirals are critical for combatting SARS-CoV-2 infections. Here, the authors develop two orally available small molecules, which specifically inhibit the activity of the SARS-CoV-2 main protease and potently block the infectivity and replication of various SARS-CoV-2 strains in cells and mice.

The ability of bone marrow to recruit transplanted hematopoietic stem cells decreases with age. Here, the authors demonstrate that this decline is caused by reduced sinusoidal shear stress due to increased non-neuronal acetylcholine degradation.

In an exploratory preplanned biomarker analysis of the phase 3 PARADIGM trial, a lack of resistance gene alterations in baseline circulating tumor DNA (negative hyperselection) was associated with prolonged overall survival after first-line panitumumab with chemotherapy in patients with RAS wild-type metastatic colorectal cancer.

Bacteria from hot springs are known for highly thermostable enzymes, which may have industrial potential. Here, a unique thermostable cellobiohydrolase is reported that can breakdown cellulose at temperature up to 95 degrees Celsius.

The mechanisms of angiogenesis in alveolar soft part sarcoma (ASPS) remain to be explored. Here, the authors highlight the role of the ASPSCR1::TFE3 fusion in regulating super-enhancer activity during the angiogenic process in ASPS.

How has the genome duplication impacted the diversification of sexual characteristics in the teleost lineage? This study shows that androgen receptor ohnologs in medaka appear to have diverged in their roles for regulating morphological and behavioural sexual characteristics after loss from an ancestral role in spermatogenesis.

It is desirable to deposit more energy in the dense plasma core to trigger the fusion ignition. Here the authors demonstrate enhanced energy coupling from laser to plasma core by using solid targets and guiding the transport of relativistic electron beam with external magnetic field.

Many causative genes are known for epileptic or developmental and epileptic encephalopathies (EE/DEE) yet a genetic diagnosis cannot be made for many patients. Here, the authors analyse whole exome sequencing data from a Japanese case−control cohort to identify common, rare and ultra-rare coding variants associated with EE/DEE.

Both poles of asteroid Ryugu, the target of space mission Hayabusa2, preserve the least processed material by space weathering. Here, the authors show detection of 700 nm absorption band in the polar spectra of Ryugu, that allows to constrain the hydrothermal history of its spectrally blue parent body.

Over the years the iron-based superconductors have become a platform to investigate many different phenomena such as the interplay between magnetism and superconductivity, nematicity and topological superconductivity. Here, the authors apply nuclear magnetic resonance to S-substituted FeSe in order to probe spin fluctuations, which indicate the presence of Bogoliubov Fermi surfaces.

Substituting hydroquinone into polyallylamine allows the resulting organic redox polymer to achieve 99% of its theoretical capacity in aqueous electrolytes. A polymer-air secondary battery fabricated with this redox polymer as the electrode-active material exhibited a constant discharge voltage, high cyclability, and high rate capability. In addition, facile acid treatment decomposes the redox polymer into its raw materials. This work demonstrates a polymer design strategy for integrating typically hydrophobic organic redox molecules into recyclable aqueous batteries.

Takeuchi et al perform cross-sectional and longitudinal analyses of associations between childhood socioeconomic status and psychometric intelligence as well as microstructural brain development in Japanese children. They report that higher socioeconomic status is associated with greater psychometric intelligence and altered microstructural properties in the fusiform gyrus which plays a role in reading and letter recognition.

Using hard X-rays for transient grating (TG) spectroscopy, fundamental excitations can be followed with femtosecond temporal and nanometer spatial resolution, selecting momenta, chemical elements and their chemical environment. The authors demonstrate the first experiment of all X-ray TG on an amorphous film of FeGd and on a silicon single crystal.

These authors contributed equally to this work:

Cross-luminescence (CL) in a barium fluoride arising from the recombination of a valence band electron and a core band hole, and intrinsically intense self-trapped exciton (STE) luminescence occurs. Herein, we report a redshift in the CL emission wavelength with high-pressure application via a sapphire anvil cell. Increasing the pressure decreases the core-valence bandgap due to the downward expansion of the valence band. The onset of a phase transition from a cubic crystal structure to an orthorhombic crystal structure at 3.7 GPa inhibited the recombination of conduction band electrons and self-trapped holes, leading to the disappearance of the STE emission.

Using conditional mutants of AID based on auxin-inducible degron system (AID2 cells), controlled immunoglobulin gene rearrangements in the B cell line DT40 facilitate the generation and stabilization of antigen-specific clones.

Katayama et al. report a vibrational spectroscopic study using ATR–FTIR of the human M2 muscarinic acetylcholine receptor (M2R). Their work involves an extensive comparison of agonists, antagonists, and inverse agonists, in which they show that they C = O stretching amide–I band is correlated with the ligand binding efficiency.