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Kinematic measurements of the Perseus galaxy cluster reveal two drivers of gas motions: a small-scale driver in the inner core associated with black-hole feedback and a large-scale driver in the outer core powered by mergers.

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

This study reveals that lysosomal dysfunction in senescent cells impairs lipid peroxidation and ferroptosis under cystine deprivation, uncovering a new mechanism of ferroptosis resistance linked to cellular senescence and providing a therapeutic strategy for age-related diseases.

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

It is important as well as challenging to map out redox activity at battery electrodes. Here, the authors present a scanning electrochemical cell microscope approach, which allows redox activity and ion flux processes at battery electrodes to be visualized with high space and time resolution.

XRISM observations show the presence of odd-numbered elements chlorine and potassium in Cas A. These findings suggest that stellar activity plays an important role in cosmic chemical evolution, enriching space with elements vital for planets and life.

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

By combining genome-wide clustered regularly interspaced short palindromic repeats with Cas9 screening and cryo-electron microscopy structure analysis, the authors identified transmembrane protein 63B as a lipid scramblase that detects structural changes in the lipid bilayer and scrambles lipids to regulate membrane lipid distributions.

The XRISM Resolve spectrum of the galactic neutron star X-ray binary, GX 13+1, reveals one of the densest winds ever seen in absorption lines.

Authors discover that the spin excitations of multiferroics convert the terahertz photon to the unidirectional charge current through the quantum geometrical aspect of optical process, paving the way to the terahertz photonics.

Mammalian genomes encode tens of thousands of ncRNAs that have important roles in regulation of gene expression and chromatin organization. Here, the authors present RADICLseq to map RNA-chromatin interactions in intact nuclei to shed light on these fine-tuned processes.

The reasons why influenza infection promotes a broader antibody response compared with vaccines are not fully understood. Here the authors show that unmasking of haemagglutinin epitopes and IL-4 signals in the germinal centre contribute to broader antibody responses after infection.

Whole-exome sequencing of colon organoids derived from patients with ulcerative colitis identifies somatic mutations in components of the IL-17 signalling pathway, which may confer a growth advantage to cells under inflammatory conditions.

A system of ultracold atoms in an optical lattice can be used as a quantum simulator for the Hubbard model with high controllability. Here, the authors report a laser spectroscopy study of an ytterbium ultracold bosonic gas across the weakly to strongly interacting regime.

Magnetoresistance, where the electric resistance of a material changes under an applied magnetic field, is typically an even function of the applied magnetic field, due to the combination of time reversal and spatial inversion symmetries. Here, Takiguchi et al show an odd-parity magnetoresistance of remarkable size in edge channels of a semiconductor quantum well.

Observations of a luminous quasar from the high-resolution spectrometer Resolve aboard XRISM revealed highly inhomogeneous wind structure outflowing from a supermassive black hole, which probably consists of up to a million clumps.

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Nishida et al. show that DNA demethylation and super-enhancer formation upregulates the transcription of inflammation genes, thereby promoting neutrophil-mediated lung metastasis in renal cell carcinoma.

Endometriosis is a major cause of infertility. Molecular mechanisms underlying the disease involve genetic and environmental risk factors. In a meta-analysis of eleven GWA studies, Sapkota and colleagues identify five novel risk loci, implicating steroid sex hormone pathways in the pathogenesis.

T follicular helper (T_FH) cells are important for the formation of germinal centers and antibody responses. Kubo and colleagues show that T_H1 cells can induce a protective antibody response in the complete absence of T_FH cells and germinal centers.

X-ray spectroscopic observations of the Centaurus galaxy cluster with the X-Ray Imaging and Spectroscopy Mission satellite show that the hot gas flows along the line of sight relative to the central galaxy.

Resistance to baloxavir marboxil, a recently approved drug to treat influenza infection, was thought to make the virus less fit. This study reports that resistant viruses isolated from Japanese patients have normal replicative abilities and pathogenicity in animal models and thus might spread in humans.

Inhibition of cell division maintains genome integrity in response to DNA damage. Here Chen et al. propose that DNA damage causes cell cycle arrest in the Arabidopsis root via Rep-MYB transcription factor-mediated repression of G2/M-specific gene expression in response to reduced cyclin-dependent kinase activity.

Jo, Inoue et al. use a machine-learning Bayesian causal forest algorithm to evaluate the effect of intensified myeloablative conditioning (MAC) on mortality following haematopoietic stem cell transplantation (HSCT). Intensified myeloablative conditioning (MAC) has heterogeneous effects on reducing mortality.

Butylated lignin was applied as a compatibilizing agent of polypropylene-based carbon fiber-reinforced plastics. The butylated lignin increased the tensile strength of the carbon fiber-reinforced plastic from 37.1 to 40.2 MPa, which was similar to what was achieved with a well-known oil-based compatibilizing agent (40.9 MPa).

An energetic eruptive filament on EK Draconis most probably launched a coronal mass ejection with a mass ten times larger than the largest solar coronal mass ejection. Studying such ejections provides insight into stellar angular momentum loss and the habitability of orbiting planets.