Nature Search

A young child formula with Limosilactobacillus reuteri and GOS modulates gut microbiome and enhances bone and muscle development: a randomized trial

Here, in a randomized clinical trial, the authors report that an experimental young child formula containing a combination of Limosilactobacillus reuteri DSM 17938 and galacto-oligosaccharides enhances bone and muscle development in early life through modulation of the microbiome.

Nicolas Bonnet
Maria Rosario Capeding
Marie-Noëlle Horcajada
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 17, P: 1-15
New Problem in Concept Formation

I. DENNIS
J. A. HAMPTON
S. E. G. LEA
Research11 May 1973
Nature

Volume: 243, P: 101-102
Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

Volume: 646, P: 1146-1155
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Modulation of metabolic, inflammatory and fibrotic pathways by semaglutide in metabolic dysfunction-associated steatohepatitis

A combination of animal studies, data from a clinical trial and insights from an observational cohort suggest that, in individuals with metabolic dysfunction-associated steatohepatitis, semaglutide improves liver histology by reverting patient proteomes to better mimic the proteome of individuals without the disease.

Maximilian Jara
Jenny Norlin
Lotte B. Knudsen
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3128-3140
International Commission on Large Dams: Congress at Delhi

F. M. LEA
News31 Mar 1951
Nature

Volume: 167, P: 505-506
Structural basis for therapeutic inhibition of complement C5

Structural and functional analyses of a new family of tick-derived C5 inhibitors in complex with inhibitor OmCI and therapeutic antibody eculizumab reveal diverse mechanisms for inhibition and provide insight into C5 activation by C5 convertases.

Matthijs M Jore
Steven Johnson
Susan M Lea
Research28 Mar 2016
Nature Structural & Molecular Biology

Volume: 23, P: 378-386
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of heparan sulfate cause autistic behaviours in mice.

Maria De Risi
Michele Tufano
Elvira De Leonibus
ResearchOpen Access09 Jun 2021
Nature Communications

Volume: 12, P: 1-17
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

The LITMUS consortium provides a resource of rodent MASLD models benchmarked against metabolic, histologic and transcriptomic features that are relevant for human MASLD. The work is useful for selecting relevant rodent models for studying this common disease.

Michele Vacca
Ioannis Kamzolas
Antonio Vidal-Puig
ResearchOpen Access12 Jun 2024
Nature Metabolism

Volume: 6, P: 1178-1196
Engineering biology applications for environmental solutions: potential and challenges

The scale of global environmental challenges requires a multi-pronged approach, which utilises all the technologies at our disposal. Here, authors provide their perspective on the potential of engineering biology for environmental biotechnology, summarizing their thoughts on the key challenges and future possibilities for the field.

David J. Lea-Smith
Francis Hassard
Natalio Krasnogor
ReviewsOpen Access14 Apr 2025
Nature Communications

Volume: 16, P: 1-12
Advancing telemedicine and task-sharing to improve access to psychotherapy for perinatal populations

Andrejek et al. evaluate the barriers and facilitators of leveraging telemedicine and task-sharing to improve access to psychotherapy for perinatal patients with symptoms of depression and anxiety in the SUMMIT trial. The qualitative implementation assessment demonstrates that both solutions are feasible, patient-centered approaches.

Nicole Andrejek
Zoë Lea
Daisy R. Singla
ResearchOpen Access30 Sept 2025
Communications Medicine

Volume: 5, P: 1-10
The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype

Senescence-associated secretory phenotype (SASP) involves secretion of factors such as pro-inflammatory cytokines. Here the authors show that MIR31HG regulates the expression and secretion of a subset of SASP components that induce paracrine invasion, through interaction with YBX1 and induction of IL1A translation.

Marta Montes
Michal Lubas
Anders H. Lund
ResearchOpen Access28 Apr 2021
Nature Communications

Volume: 12, P: 1-17
The role of anchor objects in scene function understanding

Lea Alexandra Müller Karoza
Sandro Luca Wiesmann
Melissa Lê-Hoa Võ
ResearchOpen Access23 Jun 2025
Scientific Reports

Volume: 15, P: 1-16
Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer’s and related dementias

Neguine Rezaii
Bonnie Wong
Kathy Newell
ResearchOpen Access03 Nov 2025
npj Dementia

Volume: 1, P: 1-11
Recommendations for producing knowledge syntheses to inform climate change assessments

Climate change assessment reports are increasing in complexity as the knowledge base grows exponentially. In this Perspective, the authors advocate, and provide recommendations, for knowledge synthesis to become more common as a way to better inform such assessments.

James D. Ford
Robbert Biesbroek
Max Callaghan
Reviews10 Jun 2025
Nature Climate Change

Volume: 15, P: 698-708
Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information

Regulation of gene expression and splicing are thought to be tissue-specific. Here, the authors obtain genomic and transcriptomic data from putamen and substantia nigra of 117 neurologically healthy human brains and find that splicing eQTLs are enriched for neuron-specific regulatory information.

Sebastian Guelfi
Karishma D’Sa
Mina Ryten
ResearchOpen Access25 Feb 2020
Nature Communications

Volume: 11, P: 1-16
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting autophagy and chromosomal integrity.

Søs Grønbæk Holdgaard
Valentina Cianfanelli
Francesco Cecconi
ResearchOpen Access13 Sept 2019
Nature Communications

Volume: 10, P: 1-19
Multiplexed assays of variant effect for clinical variant interpretation

Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et al. discuss the advances in MAVE technologies and guidance on how to use MAVE data in the clinic, which is helping to reveal variant pathogenicity, develop personalized drugs and inform targeted therapies.

Abbye E. McEwen
Malvika Tejura
Douglas M. Fowler
Reviews21 Jul 2025
Nature Reviews Genetics

Volume: 27, P: 137-154
Enhanced production of multi-strange hadrons in high-multiplicity proton–proton collisions

Quark–gluon plasma is an exotic state of matter that can emerge in heavy nuclei high-energy collisions. The ALICE collaboration reports the first observation of strangeness enhancement in proton–proton collisions, a possible signature of this state.

J. Adam
D. Adamová
M. Zyzak
ResearchOpen Access24 Apr 2017
Nature Physics

Volume: 13, P: 535-539
Snowmelt and laying date impact the parental care strategy of a high-Arctic shorebird

Léa Etchart
Nicolas Lecomte
Olivier Gilg
ResearchOpen Access05 Jun 2025
Scientific Reports

Volume: 15, P: 1-11
Health literacy in gastrointestinal diseases: a comparative analysis between patients with liver cirrhosis, inflammatory bowel disease and gastrointestinal cancer

Leonard Kaps
Lea Omogbehin
Christian Labenz
ResearchOpen Access06 Dec 2022
Scientific Reports

Volume: 12, P: 1-11
Smartphone-based study reminders can be a double-edged sword

Lea Nobbe
Jasmin Breitwieser
Garvin Brod
ResearchOpen Access21 Jun 2024
npj Science of Learning

Volume: 9, P: 1-10
Myocardial Gene Expression Associated with Genetic Cardiac Hypertrophy in the Absence of Hypertension

Jeremy P Dwyer
Matthew E Ritchie
Robert Di Nicolantonio
Research01 May 2008
Hypertension Research

Volume: 31, P: 941-955
Introduced species and extreme weather as key drivers of reproductive output in three sympatric albatrosses

Jaimie B. Cleeland
Deborah Pardo
Mark A. Hindell
ResearchOpen Access18 May 2020
Scientific Reports

Volume: 10, P: 1-11
Recognizing ancient papyri by a combination of spectroscopic, diffractional and chromatographic analytical tools

J. Łojewska
I. Rabin
M. Krutzsch
ResearchOpen Access06 Apr 2017
Scientific Reports

Volume: 7, P: 1-12
Lifestyle correlates of anthropometric estimates of body adiposity in an Italian middle-aged and elderly population: a covariance analysis

M L C Leite
A Nicolosi
Research24 Jan 2006
International Journal of Obesity

Volume: 30, P: 926-934

Search

A young child formula with Limosilactobacillus reuteri and GOS modulates gut microbiome and enhances bone and muscle development: a randomized trial

New Problem in Concept Formation

Polygenic and developmental profiles of autism differ by age at diagnosis

Genomics yields biological and phenotypic insights into bipolar disorder

Modulation of metabolic, inflammatory and fibrotic pathways by semaglutide in metabolic dysfunction-associated steatohepatitis

International Commission on Large Dams: Congress at Delhi

Structural basis for therapeutic inhibition of complement C5

Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

Engineering biology applications for environmental solutions: potential and challenges

Advancing telemedicine and task-sharing to improve access to psychotherapy for perinatal populations

The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype

The role of anchor objects in scene function understanding

Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer’s and related dementias

Recommendations for producing knowledge syntheses to inform climate change assessments

Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

Multiplexed assays of variant effect for clinical variant interpretation

Enhanced production of multi-strange hadrons in high-multiplicity proton–proton collisions

Snowmelt and laying date impact the parental care strategy of a high-Arctic shorebird

Health literacy in gastrointestinal diseases: a comparative analysis between patients with liver cirrhosis, inflammatory bowel disease and gastrointestinal cancer

Smartphone-based study reminders can be a double-edged sword

Myocardial Gene Expression Associated with Genetic Cardiac Hypertrophy in the Absence of Hypertension

Introduced species and extreme weather as key drivers of reproductive output in three sympatric albatrosses

Recognizing ancient papyri by a combination of spectroscopic, diffractional and chromatographic analytical tools

Lifestyle correlates of anthropometric estimates of body adiposity in an Italian middle-aged and elderly population: a covariance analysis

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