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Researchers developed a porous material ZU-921 that solves a key challenge in removing multiple different types of impurities through fine-tuning pore chemistry, enabling the one-step production of high-purity propylene.

p97-UFD1L-NPLOC4 unfolds proteins for proteasomal degradation, but whether it suffices to extract proteins from lipid bilayers is unclear. We show that the UBH-UBX module in FAF2 and its homologs double p97’s ATPase and unfolding activity, and drives membrane protein extraction.

PAK4 promotes Mdm2-mediated NLRP1 ubiquitination and degradation by phosphorylating Mdm2 at Ser186, thereby suppressing GEM-induced pyroptosis via the NLRP1/caspase-9/caspase-3/GSDME axis in pancreatic cancer cells

RSV hijacks cholesterol or autophagy pathways to facilitate optimal replication. Here, the authors show that RSV-mediated changes in lysosomal cholesterol metabolism promote RSV-F accumulation in lysosomes by blocking autophagy flux, thereby facilitating viral replication.

The mechanism of how different anion dopants influence the catalytic performance for sulfur species is currently lacking systematic theoretical studies. Here, an accurate p-p-s electronic coupling descriptor was proposed as a criterion to guide the design of anion-doped Li-S catalysts.

Xiang et al. use patient samples and mouse models of osteoarthritis to examine the link with muscle atrophy. They identify that, in osteoarthritis, senescent macrophages promote ferroptosis in skeletal muscle cells, and they show the therapeutic value of targeting this pathological mechanism.

Foundation models trained on DNA sequences have the potential to transform genomics, but systematic evaluations are scarce. Here, the authors benchmark five DNA foundation models across diverse genomic tasks, revealing key factors influencing their performance and practical application.

Hanging Coffins were a mortuary tradition practiced in southern China and Southeast Asia. Here, the authors show that different groups of ancient Hanging Coffin practitioners are genetically related, and that they are ancestors of present-day Bo people.

FHIRM-TPM 3.0 is a miniature microscope for multicolor two-photon imaging in freely moving mice. In addition to the multicolor imaging abilities achieved with the help of a specially designed optical fiber, the microscope is also compatible with multiple lenses for a choice of field of view and resolution.

This study presents a plausible emissions scenario aligned with China’s net-zero path, with CO₂ peaking in concentration by 2062 and net-zero in emissions by 2072. It projects 2.01 °C warming by 2100, with potential to stabilize below 2 °C after 2100.

Selective paraffin capture to afford high-purity olefins directly is critical but still challenging. Herein, the authors discover a distinctive ultramicroporous material featuring closely packed and linearly-extended isophthalic acid units and thus serving as a paraffin nano-trap for the efficient production of ultra-high purity olefins from paraffins.

ATG16L1 is a key autophagic protein. Here, the authors elucidate the molecular basis of ATG16L1 interactions with FIP200 and ATG8 family proteins, showing that the interaction of ATG16L1 with FIP200 is indispensable for the effective autophagic flux.

In-phase/quadrature (IQ) electro-optic modulators are underpinning devices for coherent transmission technology. Here the authors present IQ modulators in the lithium-niobate-on-insulator platform, which provide improved overall performance and advanced modulation formats for future coherent transmission systems.

Rat hepatitis E virus (HEV) can infect humans, but the extent of spillover isn’t well studied. Here the authors develop a serological test that distinguishes exposure to rat HEV from other HEV infection and show substantial spillover in a biodiversity hotspot in China. The method can support surveillance of rat HEV.

Boundary effects play a strong role in the electronic properties of structured manganites. Here, Du et al. demonstrate the existence of ferromagnetic metallic edge states and an enhanced metal–insulator transition temperature in patterned strips of manganite which emerge because of broken symmetry effects.

Organic materials potentially offer a low-cost, flexible and environment-friendly route to spintronics. Here, the authors demonstrate an organic spin-valve device in which an electric field can control both the magnitude and the sign of magnetoresistance.

In oxide materials, cation doping strongly influences the electronic correlations which promote diverse phenomena such as colossal magnetoresistance and superconductivity. Here, the authors use magnetic microscopy to image the effects of spatially ordered doping on electronic phase separation in oxide superlattices.

Radialenes have distinct structural, electronic and chemical properties from other hydrocarbons, but their synthesis remains a challenge. Here, the authors report a copper catalyzed one-step synthetic protocol of [4]radialene via the cyclotetramerization of phenylacetylene molecules upon thermal activation.

A radical-mediated dynamic remedial strategy based on bio-inspired disulfide metathesis has been developed to construct metal–organic frameworks with crystalline dynamicity. The disulfide exchange-based crystal dynamics of the metal–organic frameworks allows for sustained gas separation.

A three-photon miniature microscope with optimized light-collection efficiency facilitates imaging of neuronal activity throughout the cortex, as well as in the hippocampus, in freely moving mice.

RNF213 is a key player in fighting against various invasive pathogens in mammals. Here, the authors show that pathogenic Shigella flexneri can use its effector IpaH1.4 to directly target and subvert RNF213 to evade host antibacterial immunity.

Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.

The impact of diet on gut microbiota and metabolites in context of cancer immunotherapy remains elusive. Here the authors reveal ginger-derived exosome-like nanoparticle (GELN) aly-miR159a-3p enhances anti-PD-L1 therapy by increasing microbiota-dependent docosahexaenoic acid (DHA) level thus limiting tumor cell PD-L1 expression.

Accurate end-to-end deep learning models for adsorption prediction in porous materials would help its discovery. Here, the authors present DeepSorption, a spatial atom interaction learning network to predict structure-adsorption from atomic coordinates and chemical element types.

The distinction of liver lesions is critical for the accurate diagnosis and treatment of liver cancer. Here, the authors develop LiLNet, a deep learning-based system to identify focal liver lesions as well as benign and malignant liver tumours from CT images with high accuracy across multiple patient cohorts.

The detection of aberrations in circulating tumour DNA represents a non-invasive method to survey the oncogenes and tumour suppressors that are modified within a patient’s cancer. Here, the authors analysed more than 10,000 patients using a targeted sequencing panel and report on the frequencies of the mutations that they found.

In the IMpower151 trial, the drug combination previously shown to be effective in the IMpower150 trial was not significantly effective in a Chinese population.

PPEFs are highly conserved phosphatases. Here, authors use cryo-EM to solve the holoenzyme structures of the initially characterized PPEF family member, Drosophila RDGC, with/without Ca²⁺, uncovering a dual Ca²⁺-sensor-mediated activation mechanism.

Single-cell RNA-sequencing of seven mouse developmental stages identifies lineage-specific and shared regulatory programs controlling cell-fate decisions. Cross-species analysis associates differentiation potency with ribosomal protein gene expression.

Training foundation models often requires a costly budget and excessive computational resources. In this study, a low-cost instruction learning framework is proposed that could enable the rapid adoption of visual-language pathology applications.

The therapeutic approaches directly targeting activated β-catenin in liver cancers are restricted by toxicities. Here the authors identify that the solute carrier transporter SLC13A3 is upregulated by activation of β-catenin and silencing of SLC13A3 induces ferroptosis, which could be exploited as a therapeutic opportunity in β-catenin-driven liver cancers.

In atherosclerotic plaques, transformation of macrophages into foam cells is a key step in initiating the inflammatory response. Here Fan et al. show that casein kinase 2-interacting protein-1 (CKIP-1) limits foam cell formation and atherosclerosis by preventing expression of the scavenger receptor LOX-1 through REGγ-mediated degradation of Oct-1.

Solid-phase synthesis strategy is promising for fabricating desired complex metal nanoparticles on supports. Here, the authors synthesize CoFe@FeOx core-shell nanoparticles as the separator coatings via precise solid-phase method which effectively regulates polysulfides for lithium/ sodium-sulfur batteries.

Vibralactone is a strong lipase inhibitor and a bicyclic β-lactone containing an oxepinone ring, whose biosynthetic construction was unknown. Here the authors identify an oxepinone-building flavin monooxygenase VibO that is involved in the biosynthesis of vibralactone, and determine its X-ray crystal structure.

Single-cell RNA sequencing technology offers a unique opportunity to dissect cell heterogeneity of animals. Here, the authors construct a Xenopus cell landscape including larval and adult organs to dissect cell heterogeneity of the amphibian.