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Colourful patterns in two-dimensional lead halide perovskites are created by letting them self-etch into tiny squares that can template epitaxial growth.

Two-dimensional metal halide perovskites exhibit diverse structures, but tuning their intralayer structure is challenging. Now, ammonium-terminated bidentate linkers have been used to develop 2D perovskites. These materials exhibit superior thermal resistance and improved photovoltaic performance compared with their Ruddlesden–Popper and Dion–Jacobson counterparts.

Human stem cell–derived β cells accumulate high basal PEP, which disrupts glucose-stimulated insulin release. Restoring PKM1 lowers basal PEP and improves glucose responses, advancing the maturation of stem cell–derived islets for diabetes therapy.

Ionic liquid additives increase the power conversion efficiency of perovskite solar cells, but their effect on perovskite crystallization remains unclear. Xu et al. provide mechanistic insights and demonstrate improved operational stability under continous illumination and 90 °C thermal stress.

Mechanistic insight into how SARS-CoV-2 nsp14 methyltransferase activity installs m⁷G on host RNAs to drive stress-granule assembly.

An industry-compatible disorder-to-disorder synthesis produces wafer-scale, ultraclean monolayer amorphous carbon in seconds that can be used as a membrane for generating high-precision proton beams.

Single-cell transcriptomic profiling of immune cells in the blood and liver of a human decedent receiving a pig liver xenograft reveals impaired adaptive immunity and monocyte features that may induce T cell exhaustion and contribute to platelet activation.

Diabetes can contribute to pancreatic cancer development as well as be a consequence of it. Here, the authors report that diabetes-induced senescence of endothelial cells promotes pancreatic cancer progression.

Authors propose an entropy engineering strategy to realize the carrier-phonon decoupling in SrTiO₃-based perovskite thermoelectrics, reducing the lattice thermal conductivity nearly to the amorphous limit and improving the weighted mobility.

Structural and functional understanding of the afferent inputs to histaminergic neurons remains incomplete and lacks systematic characterization. Herein, the authors establish a comprehensive and precise whole-brain atlas of long-range inputs to mouse histaminergic neurons and investigate the representative upstream histaminergic neural circuits in regulating the sleep-wake cycle.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

This study reports on biologically sourced polymuconate polymers with weakened C–C backbone bonds, designed for closed-loop chemical recycling to monomers. Synthesized via free-radical polymerization, these materials achieve tunable mechanical properties comparable to those of commercial plastics. A techno-economic analysis shows that recycling significantly reduces costs and environmental impacts, enhancing the competitiveness of these polymers in the sustainable plastics market.

Authors use a high-entropy engineering approach to produce fully amorphous BiTO films by exfoliation and annealing, creating crystalline regions, leading to flexible ceramics with dielectric properties.

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

Asymmetric catalysis plays a crucial role in the synthesis of optically active organic molecules, but its application to stereogenic-at-metal complexes is more challenging. Here, the authors report the asymmetric synthesis of stereogenic-at-iridium complexes through kinetic resolution via a Pd-catalyzed Suzuki-Miyaura cross-coupling reaction.

Existing optogenetic methods to induce calcium mobilisation lack selectivity and specificity. Here, the authors design and engineer a single-component light-operated calcium channel to provide optical control over calcium signals and calcium-dependent physiological responses: LOCa.

Photodiodes with an intrinsic narrow spectral response make it possible to discriminate between red, green and blue light without the need for any optical filters.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

E. coli is common in humans, animals and the environment but the extent of circulation between ecological niches is unclear. Here, the authors sample ~1,000 E. coli strains from different urban aquatic ecosystems in Hong Kong and describe genomic relatedness of markers of antimicrobial resistance.

The structural transformation of crystals triggered by external stimuli is a fascinating area in materials science and supramolecular chemistry, though it is challenging to maintain crystallinity during an organic reaction. Here the authors show an example of a triethylamine vapor-induced cyclization reaction in a cocrystal, leading to its conversion into polycrystals.

Authors reveal microstructural origin of enhanced dielectric energy storage and develop a framework directly relating local inhomogeneity to dielectric properties. The results offer insights into understanding complex relaxor ferroelectrics.

Yu et al. developed AIPatient, a virtual patient that uses a large language model-based AI in curating a medical knowledge base that holds realistic and personality-aware clinical conversations. The system shows high accuracy in answering questions and medical-term recognition, with readable, reliable, and consistent outputs for medical training.

Multiple domestication-related traits in cultivated soybeans are pleiotropic effects of a locus composed of two tandemly duplicated long noncoding RNAs that act via sRNA repression of MYB transcription factors.

The STING-relayed inflammation response has been increasingly identified as one of the key drivers of NAFLD progression. Here the authors show that an E3 ubiquitin ligase, RNF13, can ameliorate NAFLD phenotypes by facilitating the TRIM29-mediated degradation of STING.

A portable multiplexed assay allows for the rapid detection, via plasmonic-gold-enhanced near-infrared fluorescence, of SARS-CoV-2 RNA at single-copy sensitivity and single-nucleotide specificity for the discrimination of variants of the virus.

Here Tai et al. unveil elevated formation of the C-terminal binding protein (CtBP)–tripartite-motif-containing protein 28 (TRIM28) complex in breast cancer cells and mutual protection between CtBP and TRIM28. This complex is required for mammary gland development and its high levels lead to breast cancer metastasis by repressing autophagy.

Polydienes are essential in industry but rely on a complex synthesis involving catalysts and solvents. Now it is shown that photo-melt-bulk polymerization enables the solvent- and catalyst-free synthesis of controlled high-molecular-weight polydienes by combining chain growth and the coupling of stable biradicals, advancing sustainable materials development.

Ultrahigh electromechanical response is accomplished by inducing extreme structural instability from competing antiferroelectric and ferroelectric orders.

Protective immunity against SARS-CoV-2 relies on both antibodies and a T cell dependent response, however, direct experimental evidence for the contribution of cellular immunity is limited. Here authors present a mouse model that is susceptible to SARS-CoV-2 and lacks B cells to demonstrate the emergence of efficient cellular immune response against SARS-CoV-2 upon vaccination or viral challenge.

In the lungs, recently identified epithelial structures known as hillocks can act as injury-resistant reservoirs of stem cells.

White-light emission from materials and devices usually occurs omni-directional through space. Here, the authors show that sintering carbon dots with TiO₂ forms a microlens-shape surface that enables directional emission with 1/60 solid angle.

Structural variations in gastric cancer impact progression. Here, the authors perform whole-genome sequencing on 168 gastric cancer patients and identified tandem-duplications of super-enhancer ZFP36L2 in 10% of gastric cancer, and mutational signatures in tumors with cadherin 1 mutations that associated with poor prognoses.

A 1 Mb non-volatile computing-in-memory system, which integrates a resistive memory array with control and readout circuits using an established 65 nm foundry CMOS process, can offer high energy efficiency and low latency for Boolean logic and multiply-and-accumulation operations.

Transposon-associated inverted repeats play a role in drought resistance and yield-related traits in maize.

This study reports that incorporating non-polar nanodomains into antiferroelectrics greatly enhanced the energy density and efficiency.

A molecular aggregate formed in a two-dimensional organic–inorganic hybrid perovskite superlattice with a near-equilibrium distance is shown to have a near-unity photoluminescence quantum yield like that of single molecules, despite being in an aggregated state.

The genome of the scallop Patinopecten yessoensis is sequenced. This bivalve mollusc has a slow-evolving genome with features such as karyotype and Hox gene expression that may be close to that of the ancestral bilaterian.

The authors propose a strategy for designing chemical short-range ordering in high-entropy ferroelectric ceramics, where elements with chemical short-range order exhibit lower local ferroelectric potential barriers.