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A self-powered symbiotic transcatheter pacemaker that regenerates energy via electromagnetic induction from the cardiac motion demonstrates a month-long operation in a porcine model of arrhythmia and surpasses the critical energy condition for lifelong service.

Metal nanoclusters are explored for their precise structures and compelling properties. Here, the authors synthesize a gold cluster with unique structural features, including giant staple motifs, tetrahedral-coordinateμ₄-S atoms, and a helical closest-packed crystallographic pattern that influences the cluster’s photoluminescence.

In a randomized controlled trial involving patients with heart failure with reduced ejection fraction, treatment with Qiliqiangxin, a traditional Chinese medicine derived from 11 types of plants, decreased the incidence of cardiac events, as compared to placebo.

Broad and potent neutralizing antibodies to SARS-CoV-2 variants can be efficiently identified via accurate deep-mutational-scanning-based prediction of viral evolution and delivered to mice using mRNA–lipid nanoparticles.

To overcome low intersystem crossing efficiency and exciton instability in organic photosensitizers, amphiphilic polymer hosts self-assemble phosphorescent molecules. This stabilizes triplet states, enabling efficient CO₂ photoreduction to CO.

Creating different pore environments within a covalent organic framework (COF) leads to useful multicompartment structure and multiple functions. Here, the authors propose a strategy to construct amphiphilic COFs with separated hydrophilic and hydrophobic nanochannels by precisely controlling the distribution of hydrophilic and hydrophobic segments in two different kinds of pores.

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

β-Hydrogen elimination is a fundamental reaction in palladium catalysis, however, the eliminated β-hydrogen is usually attached to a sp³-carbon. Here, the authors report a palladium-catalyzed cross-coupling reaction involving a β-vinylic hydrogen elimination from an allylic palladium intermediate.

Understanding correlations between molecular structures and macroscopic properties is critical in realising highly efficient organic photovoltaics. Here, the authors conduct a comprehensive study based on four non-fullerene acceptors revealing how the extended conjugation, asymmetric terminals and alkyl chain length can affect device performance.

A deep mutational scanning approach identifies mutations that allow subvariants of the prevalent JN.1 SARS-CoV-2 strain to evade Omicron-induced neutralizing antibodies, indicating a need for careful monitoring of this lineage in vaccine development.

The increase in detoxification gene expression is a common transcriptome marker for longevity interventions. Here, the authors show that nomilin extends lifespan and healthspan in animals through activation of PXR regulated detoxification functions.

Biochemical and structural studies of the interactions between antibodies and spike proteins from SARS-CoV-2 Omicron subvariants indicate how these variants have evolved to escape antibody-mediated neutralization.

Clinically identified mutations in CTCF have been linked to adverse developmental outcomes. Here, the authors explore the regulatory roles of the CTCF^R567W point mutation, by introducing it into both murine models and human embryonic stem cell-derived cortical organoid models.

Convergent mutations in hotspots of the SARS-CoV-2 Omicron receptor-binding domain can cause immune evasion and maintain sufficient ACE2-binding capability.

Exposure to early variants of SARS-CoV-2 results in immune imprinting in mouse models and in humans, reducing neutralizing antibody titres against Omicron variants, which could be mitigated with multiple updated boosters.

A strategy that depends on attenuated brassinosteroid signalling is described for the design of semi-dwarf wheat varieties with improved grain yield compared with that of green revolution varieties.

Using a single strategy to make a number of related intermediates is a useful strategy in the total synthesis. Here, the authors report the synthesis of a number of natural products, employing two diastereomerically complementary metal-catalyzed cyclizations as the key step to access a number of frameworks.

Here, Wang et al. use metagenomic sequencing to explore the impact of antibiotic treatment for Helicobacter pylori on the gut virome community in infected patients, showing that recurrent treatment leads to a lower virus community diversity and altered virus-bacteria interactions, compared with treatment naive patients.

Modulating the electronic structure of active metal sites is crucial to enhance the activity of anion-exchange membrane water electrolyzers. Here, the authors elaborate Cr-doped amorphous metal oxide catalysts with excellent activity and stability.

Molecular level control is required to capture the folding and supramolecular assembly of collagen in mimetic materials. Here, the authors report on the creation of a synthetic collagen which assembles into banded fibers, recaptures structural properties of natural collagen and which can act as a testbed for design and experimentation

Biomedical glues often face a challenge in providing strong adhesion and providing remodelling capabilities. Here the authors report on the development of a biocompatible and biodegradable protein-based coacervate adhesive and demonstrate application in haemostasis and wound healing using pig models.

The discovery of efficient drugs is a main challenge in cancer therapy. Here, the authors report a synthetic retinoid, WYC-209 with anti-tumor and anti-metastatic activity mediated by the retinoic acid receptor signaling pathway.

Chiral amines find use as chiral ligands, resolving reagents and versatile building blocks as well as in pharmaceuticals and agrochemicals. Here, the authors developed Pyrinap ligands for the copper-catalyzed enantioselective A³-coupling of terminal alkynes, aldehydes, and amines affording optically active propargylic amines.

Intermediate-depth earthquakes within the flat slab subducting beneath Peru occur and rupture within a relatively narrow region characterised by flexural strain, according to the seismicity distribution and coseismic slip distributions of four large earthquakes

Molecular motion has attracted a wide range of interest for different applications. Here, the authors develop nanoparticles with internal molecular motion upon near infrared absorption and use the nanoparticles for photoacoustic imaging and demonstrate this application in vivo.

The selective conversion of abundant and inexpensive alkane feedstocks into value-added speciality chemicals is a significant and challenging goal, and methods for catalytically converting alkanes into useful linear alkylsilanes are unknown, to date. Now, a strategy combining alkane dehydrogenation with regioselective olefin isomerization–hydrosilylation to produce linear alkylsilanes is described.

Daphenylline is an alkaloid containing a tetra-substituted arene within a sterically compact hexacyclic scaffold. Here, the first total synthesis of daphenylline is described. A gold-catalysed 6-exo-dig cyclization reaction was exploited to construct the bridged 6,6-bicycle at an early stage, the aromatic moiety was forged through a photoinduced olefin isomerization/6π electrocyclization cascade followed by oxidative aromatization.