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Here authors generate a multi-omics atlas of the perinatal Bama miniature pig brain, revealing a conserved developmental inflection point marked by large-scale transcriptomic and proteomic shifts associated with synaptogenesis and gliogenesis.

Pulmonary arterial hypertension (PAH) is a fatal disease involving disrupted metabolic and mitochondrial regulation. Here the authors show that REV-ERBα protects against PAH by repressing BNIP3-driven mitophagy in pulmonary vascular smooth muscle cells, revealing a potential circadian-based therapeutic target.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Capacitive sensors based on electronic polarization typically exhibit low sensitivity as their dielectric modulation is confined to a single mode. Here, the authors develop a dielectric-gradient all-fiber non-ionic electronic skin that converts interfacial impedance into signal amplification for tactile sensing.

This study reveals an sRNA-centered signaling pathway that activates nitrate respiration and enhances Cronobacter sakazakii virulence in oxygen-limited host environments, offering important insights into therapeutic strategies.

Here, the authors show that the PLA2G6 protein is a component of the IP3R1–GRP75–VDAC1 complex at the mitochondria-associated endoplasmic reticulum (ER) membrane, maintaining the integrity and function of ER–mitochondria contacts.

Scaling is a major challenge in engineered systems. This study employs in situ synchrotron X-ray scattering to reveal how organic matter alters nucleation and crystallization pathways, thereby regulating gypsum scaling on desalination membranes.

Conventional CMOS imagers are limited in mechanical flexibility and large-area scalability. Here, the authors develop a large-area, flexible photoelectrical impedance tomography-based imager, which can be further integrated for high-fidelity robotic three-axis tactile sensing.

Many deep learning approaches for fluorescence image restoration are task-specific and lack generalisability. Here, the authors present FluoResFM, a foundation model for multi-task and cross-distribution fluorescence microscopy image restoration. This model achieves superior restoration performance across diverse tasks, objects and imaging conditions.

Tuning the emission of metal nanoclusters is a challenge. Here, the authors report on solvation-induced isomerization and modulation of electron transfer dynamics to achieve controllable emission across the entire visible range.

Polybrominated diphenyl ethers (PBDEs) are linked to dyslipidemia, but why individuals respond differently is unclear. Here, the authors use a national biomonitoring cohort to reveal how specific genetic variants interact with PBDE exposure to increase risk, identifying a key mechanism that disrupts cholesterol metabolism.

This study reveals how the cBAF chromatin remodeling complex organizes stem cell environments and guides cell fate decisions by recruiting distinct partner proteins to maintain adult tissue homeostasis.

A dated phylogeny of 16,585 vascular plant species native to China reveals three major centres of endemism, including a potential new global biodiversity hotspot.

Bilayer CrTe₂ films grown via molecular beam epitaxy are found to host room-temperature multiferroicity and strong magnetoelectric coupling.

Floquet engineering in monolayer graphene reveals a gap opening at Floquet band crossings and coherent Floquet sidebands resolved by time- and angle-resolved photoemission spectroscopy.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

An in situ computational spectrometer, implemented on a fully integrated 576-Kb memristor chip, can reconstruct a single spectrum in 125.0 ns and consumes only 6.7 nJ of energy, achieving software-equivalent accuracy.

From the early 2010s to 2021, fine particles and fossil-fuel carbon dioxide in two Chinese cities declined, showing national clean-air policies improved both climate and air quality, according to tree-ring radiocarbon and urban air pollutant datasets

ASXL1 is often mutated in myeloid cancers. Here, the authors describe the molecular and structural mechanism by which ASXL1 associates with the transcriptional coactivator BRD4, helping to explain their high correlation in cancers.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Cheng, Wang, Feng et al. analyze over 350,000 UK Biobank participants to investigate the associations of social isolation and loneliness with cancer incidence. They find that social isolation, but not loneliness, is associated with an increased risk of developing cancer, with stronger effects observed in female and specific cancer types.

In this study, the authors have determined the crystal structure of full-length RecA from K. pneumoniae, revealing for the first time a β-strand conformation for the flexible Cterminal tail. Using a combination of biochemical techniques, they then show that this tail inhibits the formation of RecA filament, DNA binding, and DNA strand exchange during homologous recombination, but promotes LexA self-cleavage and enhances the SOS response.

A click-locking strategy inspired by click chemistry is reported that enables automated, high-throughput and industrially scalable synthesis of single-atom catalysts. By combining molecular clicking auxiliaries with robotic platforms, this approach delivers atom-precise catalysts with high activity and stability, as well as kilogram-scale manufacturability across electrocatalytic, photocatalytic and thermocatalytic reactions.

Atmospheric water harvesting (AWH) offers sustainable freshwater but faces persistent microbial safety concerns. A mussel-inspired hygroscopic aerogel achieves rapid water uptake with solar-driven bacterial inactivation, enabling a scalable AWH system.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

In this work, authors show that Legionella YopJ-family acetyltransferase effector subverts host immunity through a dual mechanism against the JAK-STAT pathway; inactivating JAK1 activity by lysine acetylation and blocking its corresponding receptor binding via direct interaction.

Radiation-induced lung injury (RILI), a serious complication of radiation exposure, is associated with cGAS-STING pathway overactivation. Here, the authors developed a nanogel based on microalgal extracellular vesicles and a cGAS inhibitor to prevent and treat RILI and its progression to fibrosis.

Noise-induced hearing loss is commonly attributed to direct damage to sensory hair cells. Here, the authors reveal that non-sensory supporting cells play a critical role in the damage through Gasdermin D-mediated exacerbation of hair cell oxidative stress.

An in situ epitaxial method can be used to grow thin films of antimony trioxide directly on two-dimensional semiconductors, such as tungsten diselenide, creating transfer-free dielectric gate stacks.

The efficiency of selenium photovoltaics is hindered by the poor crystallization of the Se film. Wen, Li, Lu and colleagues use light to initiate Se crystallization, suppressing dewetting and enabling the formation of a continuous film, which achieves a certified efficiency of 10.3%.

Phospholipid scrambling at the endoplasmic reticulum is essential for establishing a dynamic equilibrium to maintain cellular homeostasis.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.