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Showing 1–7 of 7 results
Advanced filters: Author: Luoran Shang Clear advanced filters

  • This study shows that liquid–liquid phase separation can help create and regulate pH differences across cell-like coacervate droplets, which can mimic simple cellular functions by organizing enzyme reactions and supporting basic biological processes.

    • Chong Wang
    • Zhonglin Fang
    • Luoran Shang
    ResearchOpen Access
    Nature Communications
    P: 1-14

  • This protocol describes how to produce cell-laden microfibers using capillary microfluidic devices. The devices enable spinning of increasingly complex microfibers, which can function as building blocks for 3D cell culture and tissue engineering.

    • Yunru Yu
    • Luoran Shang
    • Yuanjin Zhao
    Protocols
    Nature Protocols
    Volume: 13, P: 2557-2579

  • Alkaline phosphatase (ALP) is one of the most extensively distributed enzymes existed in living species, which could act as crucial prognostic indicators for various diseases. Here, we present novel hybrid photonic alginate hydrogel microparticles for ALP detection. An intermediary chemical, the pyrophosphate ion (PPi), was introduced to trigger the phase transition of the copper alginate hydrogel, while ALP can react with PPi and suppress the process. This response can be converted into dual optical readouts, a fluorescence signal and a structural color signal. Quantitative determination of ALP was established based on this dual-indicator system with high accuracy and reliability.

    • Yuetong Wang
    • Dagan Zhang
    • Yuanjin Zhao
    ResearchOpen Access
    NPG Asia Materials
    Volume: 14, P: 1-9

  • A flexible hemline-shaped microfiber featuring periodic parallel microcavities with sharp edges and wedges was developed using microfluidics to achieve unidirectional liquid transport along arbitrary pathways.

    • Chaoyu Yang
    • Yunru Yu
    • Yuanjin Zhao
    Research
    Nature Chemical Engineering
    Volume: 1, P: 87-96

  • Oral drug delivery is a commonly used strategy to deliver therapeutics. However, the harsh environment in the digestive tract prevents the oral administration of many drugs and can negatively affect drug efficacy. This Review discusses how biological materials and living microorganisms can be designed into bioinspired oral delivery devices that can overcome many of the challenges associated with oral delivery.

    • Xiaoxuan Zhang
    • Guopu Chen
    • Yuanjin Zhao
    Reviews
    Nature Reviews Bioengineering
    Volume: 1, P: 208-225