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Showing 1–50 of 96 results

Advanced filters: Author: Masayuki Otsuka Clear advanced filters

Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

P: 1-18
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation

The glutamate transporter GLAST in astrocyte regulates synapse function by glutamate clearance. Here, the authors show that Down syndrome cell adhesion molecule (DSCAM) in Purkinje cells controls synaptogenesis through the intercellular association with GLAST in the developing cerebellum.

Ken-ichi Dewa
Nariko Arimura
Mikio Hoshino
ResearchOpen Access01 Feb 2024
Nature Communications

Volume: 15, P: 1-18
Antitumor immunostimulatory effect via cell-killing action of a novel extracorporeal blood circulating photodynamic therapy system using 5-aminolevulinic acid

Hidetaka Maegawa
Masayuki Kohashi
Kenta Kaneda
ResearchOpen Access07 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Impact of single dose of pegfilgrastim on peripheral blood stem cell harvest in patients with multiple myeloma or malignant lymphoma

Hideki Goto
Masashi Sawa
Takanori Teshima
ResearchOpen Access25 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
An unbiased tissue transcriptome analysis identifies potential markers for skin phenotypes and therapeutic responses in atopic dermatitis

Atopic dermatitis (AD) with complex manifestations and genetic associations. Here the author profile the transcriptome of 951 skin samples from patients with AD to link skin phenotypes, clinical severity, and efficacy of dupilumab treatment to specific types of immune responses and gene features to serve clues for personalized medicine.

Ayano Fukushima-Nomura
Hiroshi Kawasaki
Masayuki Amagai
ResearchOpen Access02 Jun 2025
Nature Communications

Volume: 16, P: 1-22
Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy

This study identifies TTTCA- and TTTTA-repeat expansions in benign adult familial myoclonic epilepsy. Cortical neurons from affected people exhibit RNA foci containing these expanded repeats, suggesting RNA toxicity as the mechanism underlying disease pathogenesis.

Hiroyuki Ishiura
Koichiro Doi
Shoji Tsuji
Research05 Mar 2018
Nature Genetics

Volume: 50, P: 581-590
Clinical characteristics of Campylobacter bacteremia: a multicenter retrospective study

Yuki Otsuka
Hideharu Hagiya
Fumio Otsuka
ResearchOpen Access12 Jan 2023
Scientific Reports

Volume: 13, P: 1-6
Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma

Resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) is prevalent. Here the authors establish a biobank of patient-derived EGFR-mutant lung cancer organoids and identify a subgroup of EGFR-TKI-resistant lung adenocarcinoma organoids, which exhibit a basal-shift phenotype and vulnerability to CDK4/6 inhibitors.

Taro Shinozaki
Kazuhiro Togasaki
Toshiro Sato
ResearchOpen Access11 May 2025
Nature Communications

Volume: 16, P: 1-15
Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer

Shu Yazaki
Rui Kitadai
Kouya Shiraishi
ResearchOpen Access28 Nov 2025
npj Breast Cancer

Volume: 11, P: 1-11
Filtering out mislabeled training instances using black-box optimization and quantum annealing

Makoto Otsuka
Kento Kodama
Masayuki Ohzeki
ResearchOpen Access29 Oct 2025
Scientific Reports

Volume: 15, P: 1-14
A new fat-dissociation method to detect lymph nodes in colorectal cancer: a prospective randomized study

Shiki Fujino
Norikatsu Miyoshi
Nariaki Matsuura
ResearchOpen Access19 Nov 2020
Scientific Reports

Volume: 10, P: 1-7
Evaluation of intraocular gas using magnetic resonance imaging after pars plana vitrectomy with gas tamponade for rhegmatogenous retinal detachment

Makoto Gozawa
Masayuki Kanamoto
Masaru Inatani
ResearchOpen Access30 Jan 2020
Scientific Reports

Volume: 10, P: 1-7
Novel liver fibrosis model in Macaca fascicularis induced by thioacetamide

Megumi Matsuo
Soichiro Murata
Hideki Taniguchi
ResearchOpen Access12 Feb 2020
Scientific Reports

Volume: 10, P: 1-7
Returning genetic risk information for hereditary cancers to participants in a population-based cohort study in Japan

Kinuko Ohneda
Yoichi Suzuki
Masayuki Yamamoto
ResearchOpen Access17 Jan 2025
Journal of Human Genetics

Volume: 70, P: 147-157
CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant

Ikeda et al. report that HLA-DRB1 can serve as a leukemia-specific target for CAR T or natural killer cell-based therapy in patients with AML after allogeneic hematopoietic stem cell transplantation.

Shunya Ikeda
Kana Hasegawa
Naoki Hosen
Research24 Mar 2025
Nature Cancer

Volume: 6, P: 595-611
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Biometamaterials: Black Ultrathin Gold Film Fabricated on Lotus Leaf

Yuusuke Ebihara
Ryoichi Ota
Kotaro Kajikawa
ResearchOpen Access04 Nov 2015
Scientific Reports

Volume: 5, P: 1-6
Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Whole-exome sequencing of colon organoids derived from patients with ulcerative colitis identifies somatic mutations in components of the IL-17 signalling pathway, which may confer a growth advantage to cells under inflammatory conditions.

Kosaku Nanki
Masayuki Fujii
Toshiro Sato
Research18 Dec 2019
Nature

Volume: 577, P: 254-259
Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model

How antibody reaches tissues from circulation is critical for understanding antibody-mediated immunity. Here the authors show that IgG extravasation in the skin is mediated by endothelial caveolin transport independently of FcR, and is targetable by imatinib, which reduces IgG-dependent pathology in a mouse model of pemphigus.

Sachiko Ono
Gyohei Egawa
Kenji Kabashima
ResearchOpen Access30 Sept 2019
Nature Communications

Volume: 10, P: 1-13
Clinical significance of circulating-tumour DNA analysis by metastatic sites in pancreatic cancer

Kumiko Umemoto
Yu Sunakawa
Chigusa Morizane
Research13 Feb 2023
British Journal of Cancer

Volume: 128, P: 1603-1608
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2

Isolates of authentic SARS-CoV-2 variants BA.1 and BA.2 exhibit similar infectivity and pathogenicity and show susceptibility to neutralizing therapeutic antibodies and antiviral compounds in mouse and hamster models.

Ryuta Uraki
Maki Kiso
Yoshihiro Kawaoka
Research16 May 2022
Nature

Volume: 607, P: 119-127
Cell–matrix interface regulates dormancy in human colon cancer stem cells

A genetic lineage-tracing system in human colorectal organoids identifies a population of dormant cancer cells that persists during chemotherapy and enables cancer regrowth, and the cell-adhesion molecule COL17A1 has a key role in the process of breaking dormancy.

Yuki Ohta
Masayuki Fujii
Toshiro Sato
Research07 Jul 2022
Nature

Volume: 608, P: 784-794
Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy

Hiroyuki Ono
Hideharu Abe
Toshio Doi
ResearchOpen Access12 Jul 2018
Scientific Reports

Volume: 8, P: 1-14
Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis

Atopic dermatitis is an inflammatory skin disease featuring systemic involvement. Here authors show that the two major clinical manifestations of the disease, erythema and papulation, are distinguished by differential interplay between local skin and systemic immunity, uncovered by integrated transcriptomics.

Aiko Sekita
Hiroshi Kawasaki
Haruhiko Koseki
ResearchOpen Access02 Oct 2023
Nature Communications

Volume: 14, P: 1-16
Ultrasensitive detection of SARS-CoV-2 nucleocapsid protein using large gold nanoparticle-enhanced surface plasmon resonance

Taka-aki Yano
Taira Kajisa
Takeshi Yasui
ResearchOpen Access20 Jan 2022
Scientific Reports

Volume: 12, P: 1-8
A phase II study of the safety of olanzapine for oxaliplatin based chemotherapy in coloraectal patients

Junichi Nishimura
Akiko Hasegawa
Masayuki Ohue
ResearchOpen Access25 Feb 2021
Scientific Reports

Volume: 11, P: 1-6
Clinical characteristics of advanced non-small cell lung cancer patients with EGFR exon 20 insertions

Chie Morita
Tatsuya Yoshida
Yuichiro Ohe
ResearchOpen Access21 Sept 2021
Scientific Reports

Volume: 11, P: 1-7
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Soichi Ogishima
Satoshi Nagaie
Masayuki Yamamoto
ResearchOpen Access10 Dec 2021
Human Genome Variation

Volume: 8, P: 1-8
Visualization and targeting of LGR5⁺ human colon cancer stem cells

LGR5⁺ cells in human colorectal cancer tissue xenografted into mice act as cancer stem cells, and differentiated cancer cells can revert to cancer stem cells and express LGR5 after ablation of existing LGR5⁺ cells.

Mariko Shimokawa
Yuki Ohta
Toshiro Sato
Research29 Mar 2017
Nature

Volume: 545, P: 187-192
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Nobunao Wakabayashi
Ken Itoh
Masayuki Yamamoto
Research28 Sept 2003
Nature Genetics

Volume: 35, P: 238-245
Polyoxazoline-conjugated porcine serum albumin as an artificial plasma expander for dogs

Wataru Okamoto
Tomone Usui
Teruyuki Komatsu
ResearchOpen Access14 Jun 2023
Scientific Reports

Volume: 13, P: 1-15
Conformational Change and Orientation Fluctuations of Isotactic Polystyrene Prior to Crystallization

Go Matsuba
Keisuke Kaji
Masayuki Imai
Research01 Sept 1999
Polymer Journal

Volume: 31, P: 722-727
Nacα protects the larval fat body from cell death by maintaining cellular proteostasis in Drosophila

Protein homeostasis is crucial for maintaining cellular homeostasis. Here, the authors show that proteotoxic stress caused by Nacalpha mutants specifically and progressively induces cell death in the apoptosis-resistant Drosophila larval fat body.

Takayuki Yamada
Yuto Yoshinari
Takashi Nishimura
ResearchOpen Access01 Sept 2023
Nature Communications

Volume: 14, P: 1-19
Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library

The strong hemolytic activity and mammalian cytotoxicity of gramicidin A, a peptide antibiotic, has hindered its non-topical clinical application. Here, the authors report a high-throughput strategy for the discovery of gramicidin A analogues with altered biological activity profiles.

Yuri Takada
Hiroaki Itoh
Masayuki Inoue
ResearchOpen Access01 Oct 2020
Nature Communications

Volume: 11, P: 1-10
Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E

The depsipeptide Lysocin E has antibacterial activity against methicillin-resistant Staphylococcus aureus. Here, the authors developed a high-throughput one-bead-on-compound method for the synthesis and screening lysocin E derivatives, with several hits being more active than the parent compound.

Hiroaki Itoh
Kotaro Tokumoto
Masayuki Inoue
ResearchOpen Access05 Jul 2019
Nature Communications

Volume: 10, P: 1-11
MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice

The micro-RNA miR-33 is encoded by an intron of the gene encoding sterol regulatory-binding protein 2 (SREBP-2) and controls cholesterol homoeostasis. Here, Horie et al.identify SREBP-1 as a target of miR-33 and show that deletion of miR-33 promotes diet-induced obesity and liver steatosis in mice.

Takahiro Horie
Tomohiro Nishino
Koh Ono
ResearchOpen Access03 Dec 2013
Nature Communications

Volume: 4, P: 1-12
Prediction of seasonal climate-induced variations in global food production

Increasing volatility in food markets and the rising incidence of climatic extremes could lead to more frequent spikes in food prices. A global assessment of the reliability of crop simulations in reproducing past failures in major crop types suggests that seasonal forecasts can be useful for monitoring global food production.

Toshichika Iizumi
Hirofumi Sakuma
Toshio Yamagata
Research21 Jul 2013
Nature Climate Change

Volume: 3, P: 904-908
Genome sequencing provides high diagnostic yield and new etiological insights for intellectual disability and developmental delay

Kohei Hamanaka
Atsushi Fujita
Naomichi Matsumoto
ResearchOpen Access26 Aug 2025
npj Genomic Medicine

Volume: 10, P: 1-12
Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro

Yuji Haraguchi
Tatsuya Shimizu
Teruo Okano
Protocols05 Apr 2012
Nature Protocols

Volume: 7, P: 850-858
Comprehensive risk management for the prevention of cerebro- cardiovascular diseases in Japan

Tamio Teramoto
Masayuki Yokode
Shigeru Mizyzaki
Editorial13 Jul 2017
Hypertension Research

Volume: 40, P: 847-855
Functional evaluation of rat hearts transplanted after preservation in a high-pressure gaseous mixture of carbon monoxide and oxygen

Naoyuki Hatayama
Masayuki Inubushi
Xiao-Kang Li
ResearchOpen Access26 Aug 2016
Scientific Reports

Volume: 6, P: 1-10
Mutations in exon 7 and 8 of p53 as poor prognostic factors in patients with non-small cell lung cancer

Cheng-long Huang
Toshihiko Taki
Masayuki Miyake
Research02 Jun 1998
Oncogene

Volume: 16, P: 2469-2477
Evaluation of Bleb Fluid After Baerveldt Glaucoma Implantation Using Magnetic Resonance Imaging

Kentaro Iwasaki
Masayuki Kanamoto
Masaru Inatani
ResearchOpen Access12 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions

Dat Nguyen Tien
Masako Kishihata
Noboru Ashida
ResearchOpen Access28 May 2014
Scientific Reports

Volume: 4, P: 1-7
Efficacy of elotuzumab for multiple myeloma in reference to lymphocyte counts and kappa/lambda ratio or B2 microglobulin

Yutaka Shimazu
Junya Kanda
Junya Kuroda
ResearchOpen Access29 Mar 2023
Scientific Reports

Volume: 13, P: 1-12
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
Oral administration of ferulic acid or ethyl ferulate attenuates retinal damage in sodium iodate-induced retinal degeneration mice

Masayuki Kohno
Kunihiro Musashi
Koji Kawakami
ResearchOpen Access26 May 2020
Scientific Reports

Volume: 10, P: 1-9

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