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The recently discovered phenomena arising from 2D nanomaterials have led to an increased interest in the fabrication of other ultrathin materials from those typically only observed in the bulk. Here, the authors demonstrate the synthesis of micron-sized, single-crystalline ZnO nanosheets via solution based methods.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Evo 2 is an artificial intelligence-based biological foundation model trained on 9 trillion DNA base pairs spanning all domains of life that predicts functional properties from genomic sequences and provides a rich generative model for researchers in biology.

The experimental demonstration of a continuous and irreversible transfer of cold atoms from a ‘source mode’ to a ‘laser mode’ represents a step closer to a fully continuous atom laser.

Host–guest chemistry in hollow coordination cages can be exploited for a range of applications, but is often limited by inner cavity dimensions. Here, Schmitt and co-workers fabricate supramolecular keplerates that possess ultra-large cross-sectional diameters and are composed of multiple sub-cages.

Nickel(II) dihalide precatalysts with bidentate nitrogen ligands are widely used in cross-coupling reactions, notably in combination with photosensitizers, forming catalytic systems that currently drive major conceptual and synthetic thrusts within organic chemistry. Here the authors show a general mechanism by which these precatalysts are converted to the reduced, catalytically active species, using a range of characterization and spectroscopic techniques.

An extreme flare has been seen from a supermassive black hole at redshift z = 2.6. First detected in 2018, it is 30 times brighter than similar events. The most likely cause is the shredding of a star of 30 solar masses or more.

Meta-analysis shows people’s views on climate change have only a small impact on their tendencies to act in climate-friendly ways. These views are affected more by ideology and political orientation than education, sex and experience of extreme weather.

Warm and moist air-mass intrusions into the Arctic are more frequent than the past decades. Here, the authors show that warm air mass intrusions from northern Eurasia inject record amounts of aerosols into the central Arctic Ocean strongly impacting atmospheric chemistry and cloud properties.

Interacting electrons in Hofstadter bands can form symmetry-broken topological states. These are now revealed in magic-angle twisted bilayer graphene, and their properties are influenced by non-uniform quantum geometry.

Analyses of data on 21 billion friendships from Facebook in the United States reveal associations between social capital and economic mobility.

Social disconnection across socioeconomic lines is explained by both differences in exposure to people with high socioeconomic status and friending bias—the tendency for people to befriend peers with similar socioeconomic status even conditional on exposure.

Nucleation and growth of mineral crystals plague surfaces in contact with supersaturated fluids such as heat exchangers. Here, authors achieve near complete ( > 92%) mitigation of CaCO3 precipitation via alternating electric field and elucidate the mechanism through ion displacement and EDL charging.

The social cost of carbon (SCC) is usually calculated by an approach that gives less importance to future generations and does not consider well-being distribution. This study presents an alternative that takes these aspects into account.

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

If the world can meet the target of limiting global warming to 1.5 °C, economic damage will probably be greatly reduced, especially in poorer countries.

Understanding the drivers of opposition to renewable energy infrastructure is increasingly important. Here the authors find an association between wind farm opposition and belief in conspiracy theories and test the effectiveness of information provision in countering it.

Sea spray aerosol (SSA) are an important way through which oceans can influence the atmosphere’s radiative properties. Here, the authors present measurements taken over a 42,000 km ship cruise in the Atlantic and Pacific Ocean and show that SSA number concentrations vary over a 24-hour cycle, possibly linked to surface water bubble-bursting dynamics.

Will voluntary carbon markets genuinely tackle climate change or could they encourage further emissions?

Observations from the Lucy spacecraft of the small main-belt asteroid (152830) Dinkinesh reveals unexpected complexity, with a longitudinal trough and equatorial ridge, as well as the discovery of the first contact binary satellite.

Despite the potential of fluorinated compounds in pharmaceuticals and agrochemicals, the formation of C–F bonds remains challenging. It has now been shown that aryl sulfonium salts, which can be made by site-selective C–H functionalization, have advantageous photoredox reactivity compared to conventional (pseudo)halides and can be used for late-stage C–H fluorination.

Topological quantum computation schemes — where quantum information is stored non-locally — provide, in theory, an elegant way of avoiding the deleterious effects of decoherence, but they have proved difficult to realize experimentally. A proposal to engineer topological phases into networks of one-dimensional semiconducting wires should bring topological quantum computers a step closer.

Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.

A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.

Origami is widely practiced in the design of foldable structures for smart applications and usually consists of stiff sheets that only deform along prescribed creases. Pinsonet al. take a statistical physics approach to design and characterize arbitrary patterns as a function of folding energy.

A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

The Arctic is changing faster than anywhere else on Earth. Interactions between clouds and aerosols play a role in these changes. We report how the quantities and origins of aerosols that affect cloud ice formation change over a full sea ice cycle

Ultracold polar molecules are an excellent platform for quantum science but experiments so far see fast trap losses that are poorly understood. Here the authors investigate collisional losses of nonreactive RbCs, and show they are consistent with the sticky collision hypothesis, but are slower than the universal rate.

Many bacteria can take up exogenous DNA, in a process that often requires surface appendages composed of thousands of protein subunits called pilins. Here, Braus et al. show that a minor pilin binds directly to DNA and is important for DNA uptake in the pathogen Legionella pneumophila.

APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE2 homozygotes had an exceptionally low risk.

Most kimberlites erupting in the past billion years on Earth did so about 30 million years after continental breakup, with dynamical and analytical models suggesting a control from rifting-related mantle delamination.

The development of a first-in-class non-covalent small-molecule inhibitor of SARS-CoV-2 replication that targets the viral guanine-N7 methyltransferase NSP14 is reported.

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

A single electromagnetically trapped proton is sympathetically cooled to below ambient temperature by coupling it through a superconducting LC circuit to a laser-cooled cloud of Be⁺ ions stored in a spatially separated trap.

Although the synthetic chemistry of carbon dioxide has generally been limited to two-electron pathways, single-electron mechanisms would open avenues to new reactivity. Now, the coupling of carbon dioxide and amines to produce α-amino acids can be achieved by an organic photoredox catalyst in continuous flow.

Methods for high-throughput and high-resolution dissection of enhancers in Drosophila are described by two independent groups.

Experiments using high-intensity X-ray pulses incident on high-pressure hydrocarbons suggest that diamond formation can occur at shallower depths in icy planets and may play a role in the internal convection that generates their magnetic fields.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

A small-molecule activator specific for PKM2 binds to a site distinct from the endogenous activator fructose-1,6-bisphosphate, promoting tetramerization and constitutive activation of PKM2, to inhibit xenograft tumor growth in mice.

Charlet, Grinevich et al. show that social touch between female rats activates parvocellular oxytocin neurons; these neurons control social behavior by coordinating the responses of the much larger population of magnocellular oxytocin neurons.