Nature Search

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis

Fatty liver disease exacerbates atherosclerosis, but the underlying mechanisms remain unclear. Here, the authors show that D-dopachrome tautomerase (D-DT/MIF-2) acts as an atypical chemokine, promoting both atherosclerosis and hepatic lipid accumulation.

Omar El Bounkari
Chunfang Zan
Jürgen Bernhagen
ResearchOpen Access07 Mar 2025
Nature Communications

Volume: 16, P: 1-30
deepmriprep: voxel-based morphometry preprocessing via deep neural networks

deepmriprep leverages neural networks to enable voxel-based morphometry preprocessing of MRI data that is 37× faster than existing methods while achieving comparable accuracy in segmentation, registration and final statistical maps across large datasets.

Lukas Fisch
Nils R. Winter
Tim Hahn
ResearchOpen Access30 Jan 2026
Nature Computational Science

Volume: 6, P: 250-259
Epigenetically driven and early immune evasion in colorectal cancer evolution

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

Eszter Lakatos
Vinaya Gunasri
Trevor A. Graham
ResearchOpen Access05 Nov 2025
Nature Genetics

Volume: 57, P: 3039-3049
Learning curve evaluation upskilling retinal imaging using smartphones

Linus G. Jansen
Payal Shah
Maximilian W. M. Wintergerst
ResearchOpen Access16 Jun 2021
Scientific Reports

Volume: 11, P: 1-8
Mammal responses to global changes in human activity vary by trophic group and landscape

Analysing camera-trap data of 163 mammal species before and after the onset of COVID-19 lockdowns, the authors show that responses to human activity are dependent on the degree to which the landscape is modified by humans, with carnivores being especially sensitive.

A. Cole Burton
Christopher Beirne
Roland Kays
ResearchOpen Access18 Mar 2024
Nature Ecology & Evolution

Volume: 8, P: 924-935
Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma

Graham and colleagues analyzed locally advanced esophageal adenocarcinoma clinical trial patient samples and identified major changes in gene expression profiles and immune microenvironment composition independent of changes in clonal composition.

Melissa Barroux
Jacob Househam
Trevor A. Graham
ResearchOpen Access14 May 2025
Nature Cancer

Volume: 6, P: 820-837
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

This genome-wide study of age at first sexual intercourse and first birth identifies 371 signals driven by reproductive biology, externalising behaviour and environmental effects, with later onset associated with lower incidence of some diseases.

Melinda C. Mills
Felix C. Tropf
Felix R. Day
Research01 Jul 2021
Nature Human Behaviour

Volume: 5, P: 1717-1730
Decoding chromatin states by proteomic profiling of nucleosome readers

A multidimensional proteomics analysis of the interactions between around 2,000 nuclear proteins and over 80 modified dinucleosomes representing promoter, enhancer and heterochromatin states provides insights into how chromatin states are decoded by chromatin readers.

Saulius Lukauskas
Andrey Tvardovskiy
Till Bartke
ResearchOpen Access06 Mar 2024
Nature

Volume: 627, P: 671-679
Coupling to octahedral tilts in halide perovskite nanocrystals induces phonon-mediated attractive interactions between excitons

Time-resolved measurements show that coupling between electrons and phonons in lead halide perovskites can mediate attractive interactions between excitons, although the interaction strength depends on the specific material.

Nuri Yazdani
Maryna I. Bodnarchuk
Aaron M. Lindenberg
ResearchOpen Access09 Nov 2023
Nature Physics

Volume: 20, P: 47-53
The co-evolution of the genome and epigenome in colorectal cancer

A study maps genetic and epigenetic heterogeneity of primary colorectal adenomas and cancers at single-clone resolution through spatial multi-omic profiling of individual glands and adjacent normal tissue.

Timon Heide
Jacob Househam
Andrea Sottoriva
ResearchOpen Access26 Oct 2022
Nature

Volume: 611, P: 733-743
Phenotypic plasticity and genetic control in colorectal cancer evolution

Intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.

Jacob Househam
Timon Heide
Trevor A. Graham
ResearchOpen Access26 Oct 2022
Nature

Volume: 611, P: 744-753
Immunosuppressive niche engineering at the onset of human colorectal cancer

Integration of mathematical modeling, ecological analyses of patient biopsies, and neoantigen heterogeneity suggests recruitment of immunosuppressive cells is key to initializing transformation from adenoma to carcinoma in human colorectal cancer.

Chandler D. Gatenbee
Ann-Marie Baker
Alexander R. A. Anderson
ResearchOpen Access04 Apr 2022
Nature Communications

Volume: 13, P: 1-16
Nanocrystal superlattices as phonon-engineered solids and acoustic metamaterials

Phonon engineering enables tailored heat-transfer properties, controlled elastic and acoustic vibration propagation, and custom phonon-electron and phonon-photon interactions. Here, the authors present an approach for the observation and tunability of vibrational modes of nanocrystal superlattices.

Nuri Yazdani
Maximilian Jansen
Vanessa Wood
ResearchOpen Access17 Sept 2019
Nature Communications

Volume: 10, P: 1-6
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Analyses of expression profiles from whole blood of 31,684 individuals identify cis-expression quantitative trait loci (eQTL) effects for 88% of genes and trans-eQTL effects for 37% of trait-associated variants.

Urmo Võsa
Annique Claringbould
Lude Franke
Research02 Sept 2021
Nature Genetics

Volume: 53, P: 1300-1310
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

Xueyi Shen
David M. Howard
Andrew M. McIntosh
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-16
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Many genetic variants identified in genome-wide association studies are associated with gene expression. Here, Porcu et al. propose a transcriptome-wide summary statistics-based Mendelian randomization approach (TWMR) that, applied to 43 human traits, uncovers hundreds of previously unreported gene–trait associations.

Eleonora Porcu
Sina Rüeger
Zoltán Kutalik
ResearchOpen Access24 Jul 2019
Nature Communications

Volume: 10, P: 1-12
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling

Patients with primary sclerosing cholangitis (PSC), a chronic cholestatic liver disease, display changes in the gut microbiota and in bile acid composition. Schneider, Candels and colleagues identify a role for microbiota-dependent regulation of bile acid synthesis through farnesoid X receptor signalling, which is relevant for PSC disease progression.

Kai Markus Schneider
Lena Susanna Candels
Christian Trautwein
Research22 Sept 2021
Nature Metabolism

Volume: 3, P: 1228-1241
OTTERS: a powerful TWAS framework leveraging summary-level reference data

Here, the authors present a TWAS framework OTTERS that adapts multiple polygenic risk score methods to estimate eQTL weights from summary-level eQTL data. Both simulation and real studies show OTTERS is powerful across a wide range of genetic architectures.

Qile Dai
Geyu Zhou
Jingjing Yang
ResearchOpen Access07 Mar 2023
Nature Communications

Volume: 14, P: 1-13
Publisher Correction: Identification of 371 genetic variants for age at first sex and birth linked to externalising behavior

Melinda C. Mills
Felix C. Tropf
Felix R. Day
Amendments and Corrections28 Jul 2021
Nature Human Behaviour

Volume: 5, P: 1111
Assessment of body composition in the advanced stage of castration-resistant prostate cancer: special focus on sarcopenia

Judith Stangl-Kremser
Rodrigo Suarez‐Ibarrola
Pascal Baltzer
Research19 Nov 2019
Prostate Cancer and Prostatic Diseases

Volume: 23, P: 309-315
Promoting sustainable behavior: addressing user clusters through targeted incentives

Laura Höpfl
Maximilian Grimlitza
Maria Wirzberger
ResearchOpen Access12 Sept 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-12
A-Maze-Ox: a novel gas-exchange-area-adjustable oxygenator for extremely preterm infants—design and proof of concept

Franziska Schubert
Jan Heyer
Mark Schoberer
ResearchOpen Access17 Jan 2026
Pediatric Research

P: 1-8
Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study

Siwei Liu
Ingrid Agartz
Therese AMJ van Amelsvoort
ResearchOpen Access22 Oct 2025
Molecular Psychiatry

Volume: 31, P: 1707-1722
Cold-atom quantum simulators of gauge theories

Large-scale quantum simulations of gauge theories are relevant to high-energy and condensed matter physics. This Review covers recent developments in simulating lattice gauge theories using cold atoms.

Jad C. Halimeh
Monika Aidelsburger
Bing Yang
Reviews15 Jan 2025
Nature Physics

Volume: 21, P: 25-36
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
Amendments and CorrectionsOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-2
Multimodal workflows optimally predict response to repetitive transcranial magnetic stimulation in patients with schizophrenia: a multisite machine learning analysis

Mark Sen Dong
Jaroslav Rokicki
Nikolaos Koutsouleris
ResearchOpen Access25 Apr 2024
Translational Psychiatry

Volume: 14, P: 1-11
Nanocrystal phononics

Colloidal nanocrystals can form into periodic superlattices exhibiting collective vibrations from the correlated motion of the nanocrystals. This Perspective discusses such collective vibrations and their as-of-yet untapped potential applications for phononic crystals, acoustic metamaterials and optomechanical systems.

Maximilian Jansen
William A. Tisdale
Vanessa Wood
Reviews26 Jan 2023
Nature Materials

Volume: 22, P: 161-169
The German Network for Personalized Medicine to enhance patient care and translational research

A. L. Illert
A. Stenzinger
N. P. Malek
Correspondence06 Jun 2023
Nature Medicine

Volume: 29, P: 1298-1301
Colloidal quantum dot electronics

This Review examines the use of colloidal quantum dots in the development of next-generation electronics, including luminescent, optoelectronic, memory and thermoelectric devices.

Mengxia Liu
Nuri Yazdani
Edward H. Sargent
Reviews12 Aug 2021
Nature Electronics

Volume: 4, P: 548-558
Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients

Pei Shang
Ada Man-Choi Ho
Doo-Sup Choi
ResearchOpen Access03 Jun 2022
Translational Psychiatry

Volume: 12, P: 1-10
Lipid-encapsulated siRNA for hepatocyte-directed treatment of advanced liver disease

Marius Maximilian Woitok
Miguel Eugenio Zoubek
Francisco Javier Cubero
ResearchOpen Access11 May 2020
Cell Death & Disease

Volume: 11, P: 1-14
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Research23 Jan 2020
Molecular Psychiatry

Volume: 25, P: 1430-1446
Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes

Michael G. Gottschalk
Jan Richter
Katharina Domschke
ResearchOpen Access04 Feb 2019
Translational Psychiatry

Volume: 9, P: 1-13
Regulatory landscape of providing information on newborn screening to parents across Europe

Věra Franková
Riona O. Driscoll
Katrin Õunap
Research10 Oct 2020
European Journal of Human Genetics

Volume: 29, P: 67-78
Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control

Jana Müller
Charlotte Kreutz
Markus Weiler
ResearchOpen Access27 Jan 2021
Scientific Reports

Volume: 11, P: 1-10
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Transdiagnostic evaluation of epigenetic age acceleration and burden of psychiatric disorders

Natan Yusupov
Linda Dieckmann
Elisabeth B. Binder
ResearchOpen Access17 Apr 2023
Neuropsychopharmacology

Volume: 48, P: 1409-1417
Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Amendments and Corrections18 May 2020
Molecular Psychiatry

Volume: 26, P: 5465

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