Nature Search

The Dynamic Structure of Regioregulated Poly(4-methylthiazole-2,5-diyl)

Seiichiro Mori
Takakazu Yamamoto
Yoshio Inoue
Research19 Mar 2008
Polymer Journal

Volume: 40, P: 475-478
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Target protein-oriented isolation of Hes1 dimer inhibitors using protein based methods

Midori A. Arai
Kaori Morita
Masami Ishibashi
ResearchOpen Access28 Jan 2020
Scientific Reports

Volume: 10, P: 1-9
The Notch inhibitor cowanin accelerates nicastrin degradation

Midori A. Arai
Ryuta Akamine
Masami Ishibashi
ResearchOpen Access29 Mar 2018
Scientific Reports

Volume: 8, P: 1-10
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulina

Midori A. Arai
Yuna Makita
Masami Ishibashi
ResearchOpen Access08 Dec 2020
Scientific Reports

Volume: 10, P: 1-8
Isolation of nocobactin NAs as Notch signal inhibitors from Nocardia farcinica, a possibility of invasive evolution

Midori A. Arai
Itsuki Ebihara
Masami Ishibashi
Research14 Dec 2020
The Journal of Antibiotics

Volume: 74, P: 255-259
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
An activated mutant of R-Ras inhibits cell death caused by cytokine deprivation in BaF3 cells in the presence of IGF-I

Jotaro Suzuki
Yoshito Kaziro
Hiroshi Koide
Research02 Oct 1997
Oncogene

Volume: 15, P: 1689-1697
Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation

Shiina Suzuki
Shun Saito
Midori A. Arai
Research08 Nov 2023
The Journal of Antibiotics

Volume: 77, P: 30-38
Preparation of Soluble Polypyrrole with -C≡C-p-C₆H₄-hexyl Side Chains at the N-Position and Its Self-assembling Behavior

Risako Yamashita
Take-aki Koizumi
Takakazu Yamamoto
Research26 Sept 2007
Polymer Journal

Volume: 39, P: 1202-1206
Preparation of New π-Conjugated Thiophene-Pyrrole Copolymers Having Ethynyl Substituents at the N-Position of Pyrrole

Takakazu Yamamoto
Risako Yamashita
Research11 Jun 2008
Polymer Journal

Volume: 40, P: 775-778
Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41

Shun Saito
Shiina Suzuki
Midori A. Arai
Research02 Aug 2022
The Journal of Antibiotics

Volume: 75, P: 509-513
Aspergillus terreus IFM 65899-THP-1 cells interaction triggers production of the natural product butyrolactone Ia, an immune suppressive compound

Yukiko Ujie
Shun Saito
Midori A. Arai
ResearchOpen Access16 Nov 2024
Scientific Reports

Volume: 14, P: 1-11
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Ub-ProT reveals global length and composition of protein ubiquitylation in cells

Ubiquitylation is a dynamic post-translational modification involved in the regulation of numerous cellular processes. Here the authors describe Ub-ProT: a method to measure the length of substrate-attached ubiquitin chains in biological samples, and demonstrate a critical role for chain length in directing substrates to specific cellular pathways.

Hikaru Tsuchiya
Daocharad Burana
Yasushi Saeki
ResearchOpen Access06 Feb 2018
Nature Communications

Volume: 9, P: 1-10
A Reversible Rocksalt to Amorphous Phase Transition Involving Anion Redox

Atsushi Sakuda
Koji Ohara
Hikari Sakaebe
ResearchOpen Access10 Oct 2018
Scientific Reports

Volume: 8, P: 1-6
Reduced PLP1 expression in induced pluripotent stem cells derived from a Pelizaeus–Merzbacher disease patient with a partial PLP1 duplication

Keiko Shimojima
Takahito Inoue
Toshiyuki Yamamoto
Research14 Jun 2012
Journal of Human Genetics

Volume: 57, P: 580-586
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Environmental RNA interference in two-spotted spider mite, Tetranychus urticae, reveals dsRNA processing requirements for efficient RNAi response

Nicolas Bensoussan
Sameer Dixit
Vojislava Grbic
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-16
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Green fluorescent protein-based lactate and pyruvate indicators suitable for biochemical assays and live cell imaging

Kazuki Harada
Takami Chihara
Takashi Tsuboi
ResearchOpen Access11 Nov 2020
Scientific Reports

Volume: 10, P: 1-11
Real-time observations of lithium battery reactions—operando neutron diffraction analysis during practical operation

Sou Taminato
Masao Yonemura
Ryoji Kanno
ResearchOpen Access30 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
SnRK2 protein kinases represent an ancient system in plants for adaptation to a terrestrial environment

Akihisa Shinozawa, Ryoko Otake et al. report on an ancient subclass of the SNF1-related protein kinase 2 family involved in ABA signaling, which protect moss from drought stress. They propose that this signaling module evolved in early land plants to regulate dehydration-response.

Akihisa Shinozawa
Ryoko Otake
Yoichi Sakata
ResearchOpen Access21 Jan 2019
Communications Biology

Volume: 2, P: 1-13

Search

The Dynamic Structure of Regioregulated Poly(4-methylthiazole-2,5-diyl)

DOCK2 is involved in the host genetics and biology of severe COVID-19

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Target protein-oriented isolation of Hes1 dimer inhibitors using protein based methods

The Notch inhibitor cowanin accelerates nicastrin degradation

Blood DNA virome associates with autoimmune diseases and COVID-19

Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulina

Isolation of nocobactin NAs as Notch signal inhibitors from Nocardia farcinica, a possibility of invasive evolution

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

An activated mutant of R-Ras inhibits cell death caused by cytokine deprivation in BaF3 cells in the presence of IGF-I

Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation

Preparation of Soluble Polypyrrole with -C≡C-p-C₆H₄-hexyl Side Chains at the N-Position and Its Self-assembling Behavior

Preparation of New π-Conjugated Thiophene-Pyrrole Copolymers Having Ethynyl Substituents at the N-Position of Pyrrole

Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41

Aspergillus terreus IFM 65899-THP-1 cells interaction triggers production of the natural product butyrolactone Ia, an immune suppressive compound

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Ub-ProT reveals global length and composition of protein ubiquitylation in cells

A Reversible Rocksalt to Amorphous Phase Transition Involving Anion Redox

Reduced PLP1 expression in induced pluripotent stem cells derived from a Pelizaeus–Merzbacher disease patient with a partial PLP1 duplication

Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Environmental RNA interference in two-spotted spider mite, Tetranychus urticae, reveals dsRNA processing requirements for efficient RNAi response

Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Green fluorescent protein-based lactate and pyruvate indicators suitable for biochemical assays and live cell imaging

Real-time observations of lithium battery reactions—operando neutron diffraction analysis during practical operation

SnRK2 protein kinases represent an ancient system in plants for adaptation to a terrestrial environment

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