Nature Search

Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunotherapy

Leukemic stem cells (LSCs) drive relapse and therapy resistance in acute myeloid leukemia (AML). Here, the authors show that increasing the stiffness of LSCs reduces their stemness and enhances their susceptibility to natural killer cell-mediated immunotherapy in AML.

Mingming Zhu
Haoxiang Yang
Fang Ni
ResearchOpen Access01 Dec 2025
Nature Communications

Volume: 16, P: 1-19
Library-based virtual match-between-runs quantification in GlyPep-Quant improves site-specific glycan identification

The poor interpretation of glycopeptide spectra limits the site-specific glycan quantification at the proteomics scale. Here, the authors develop GlyPep-Quant, a glycopeptide quantification tool using library-based match-between-runs strategy, to enhance coverage of site-specific glycan analysis.

He Zhu
Zheng Fang
Mingliang Ye
ResearchOpen Access14 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone

The corticotropic-releasing hormone enhances the bone-marrow homing and engraftment of human haematopoietic stem and progenitor cells via the mechanical remodelling of the cell’s cytoskeleton and the extracellular matrix.

Mingming Wu
Haoxiang Yang
Fang Ni
Research23 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 754-771
Screening of F-containing electrolyte additives and clarifying their decomposition routes for stable Li metal anodes

A F-containing additive with efficient LiF contribution is urgent for Li metal batteries. The authors report a hexafluoroglutaric anhydride additive with a 91% conversion, enabling the Li metal anode with a LiF-rich interphase in regular electrolyte.

Jijiang Liu
Wei Hao
Zheng Liang
ResearchOpen Access29 Oct 2024
Nature Communications

Volume: 15, P: 1-12
Efficacy of High-intensity Statin Use for Transient Ischemic Attack Patients with Positive Diffusion-weighted Imaging

Bo Song
Yuan Cao
Yuming Xu
ResearchOpen Access04 Feb 2019
Scientific Reports

Volume: 9, P: 1-5
The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes

A study finds that RUVBL2 is a conserved component of eukaryotic circadian clocks and suggests that slow ATPase activity, which was initially discovered in cyanobacteria, is a shared feature of eukaryotic clocks.

Meimei Liao
Yanqin Liu
Eric Erquan Zhang
ResearchOpen Access26 Mar 2025
Nature

Volume: 642, P: 165-173
Metal artifact reduction through MVCBCT and kVCT in radiotherapy

Gao Liugang
Sun Hongfei
Lin Tao
ResearchOpen Access21 Nov 2016
Scientific Reports

Volume: 6, P: 1-11
Publisher Correction: The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes

Meimei Liao
Yanqin Liu
Eric Erquan Zhang
Amendments and CorrectionsOpen Access19 Jun 2025
Nature

Volume: 643, P: E12
Retraction Note: A switch in the poly(dC)/RmlB complex regulates bacterial persister formation

Xu Chen
Gen Li
Kouhong Sun
Amendments and CorrectionsOpen Access11 Jul 2019
Nature Communications

Volume: 10, P: 1
Glyco-Decipher enables glycan database-independent peptide matching and in-depth characterization of site-specific N-glycosylation

Poor peptide fragmentation and unusual glycan structures limit mass spectrometry-based analysis of intact N-glycopeptides. Here, the authors develop Glyco-Decipher, a glycan-independent peptide search tool, to tackle these issues and improve the coverage of site-specific glycan analysis.

Zheng Fang
Hongqiang Qin
Mingliang Ye
ResearchOpen Access07 Apr 2022
Nature Communications

Volume: 13, P: 1-15
CAR-T cell therapy-related cytokine release syndrome and therapeutic response is modulated by the gut microbiome in hematologic malignancies

The success rate of chimeric antigen receptor T cell therapy is high in blood cancers, yet individual patient characteristics might reduce therapeutic benefit. Here authors show that therapeutic response in multiple myeloma, acute lymphoblastic leukemia and non-Hodgkin lymphoma, and occurrence of severe cytokine release syndrome in multiple myeloma are associated with specific gut microbiome alterations.

Yongxian Hu
Jingjing Li
He Huang
ResearchOpen Access09 Sept 2022
Nature Communications

Volume: 13, P: 1-14
Bioinspired ultra-stretchable and anti-freezing conductive hydrogel fibers with ordered and reversible polymer chain alignment

High-performance stretchable conductive fibers are desired for the development of stretchable electronic devices but preparation of conductive hydrogel fibers is challenging. Inspired by spider silk the authors demonstrate here a spinning method to prepare stretchable conductive hydrogel fibers with ordered polymer chain alignment.

Xue Zhao
Fang Chen
Mingming Ma
ResearchOpen Access04 Sept 2018
Nature Communications

Volume: 9, P: 1-8
Author Correction: CAR-T cell therapy-related cytokine release syndrome and therapeutic response is modulated by the gut microbiome in hematologic malignancies

Yongxian Hu
Jingjing Li
He Huang
Amendments and CorrectionsOpen Access27 Mar 2024
Nature Communications

Volume: 15, P: 1
HBV reactivation in patients with chronic or resolved HBV infection following BCMA-targeted CAR-T cell therapy

Shan Fu
Qiqi Zhang
He Huang
Research31 Mar 2023
Bone Marrow Transplantation

Volume: 58, P: 701-709
The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction

The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-1 transcription, and show that inhibition of SUV39H in mice is cardioprotective.

Guang Yang
Xinyu Weng
Aijun Sun
ResearchOpen Access31 Mar 2017
Nature Communications

Volume: 8, P: 1-15
Epirubicin induces cardiotoxicity through disrupting ATP6V0A2-dependent lysosomal acidification and triggering ferroptosis in cardiomyocytes

Mingming Zhang
Xin Wu
Junhong Wang
ResearchOpen Access24 Jul 2024
Cell Death Discovery

Volume: 10, P: 1-11
A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands

The peptide-centric local stability assay (PELSA) can be used to determine ligand-binding targets and binding regions on a proteome-wide scale with high sensitivity.

Kejia Li
Shijie Chen
Mingliang Ye
Research10 Dec 2024
Nature Methods

Volume: 22, P: 278-282
RETRACTED ARTICLE: A switch in the poly(dC)/RmlB complex regulates bacterial persister formation

The mechanisms underlying bacterial persisters formation remain poorly understood. Here, Chen et al. identify a complex formed by extracellular poly(dC) and the binding protein RmlB that controls Pseudomonas aeruginosa persister formation in response to environmental stimuli.

Xu Chen
Gen Li
Kouhong Sun
ResearchOpen Access03 Jan 2019
Nature Communications

Volume: 10, P: 1-14
Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis

Lina Sun
Zhiwen Fan
Yong Xu
ResearchOpen Access21 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

Mingming Zhang
Fang Cai
Weihong Song
ResearchOpen Access03 Dec 2014
Scientific Reports

Volume: 4, P: 1-6
Preoperative comprehensive risk estimation for axillary lymph node metastasis in breast cancer: development and verification of a network-based prediction model

Baoqi Sun
Guangdong Shao
Guolou Li
ResearchOpen Access09 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
Cardiac-specific overexpression of Ndufs1 ameliorates cardiac dysfunction after myocardial infarction by alleviating mitochondrial dysfunction and apoptosis

Bingchao Qi
Liqiang Song
Yan Li
ResearchOpen Access11 Jul 2022
Experimental & Molecular Medicine

Volume: 54, P: 946-960
Combining Sentinel-2 and diverse environmental data largely improved aboveground biomass estimation in China’s boreal forests

Pan Liu
Chunying Ren
Huixin Ren
ResearchOpen Access11 Nov 2024
Scientific Reports

Volume: 14, P: 1-17
Cytotoxic glutarimide-containing polyketides isolated from Streptomyces sp. JCM 4793

Lin-Fang Tang
Wu-Lai Jihuo
Yan-Yun Che
Research30 May 2024
The Journal of Antibiotics

Volume: 77, P: 627-633
Ferroptosis is involved in focal segmental glomerulosclerosis in rats

Yue Shi
Xiujie Shi
Yu Zhang
ResearchOpen Access14 Dec 2023
Scientific Reports

Volume: 13, P: 1-11
Epigenetic regulation of lung cancer cell proliferation and migration by the chromatin remodeling protein BRG1

Zilong Li
Jun Xia
Yong Xu
ResearchOpen Access06 Nov 2019
Oncogenesis

Volume: 8, P: 1-14
MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response

Liming Yu
Fei Fang
Yong Xu
ResearchOpen Access15 Mar 2017
Scientific Reports

Volume: 7, P: 1-13
Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity

Lu Fang
Changjie Liu
Lemin Zheng
ResearchOpen Access23 Aug 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-17
Heterologous expression of the TaPI-PLC1-2B gene enhanced drought and salt tolerance in transgenic rice seedlings

Ahui Zhao
Chao Cui
Mingming Yang
Research17 Oct 2022
Heredity

Volume: 129, P: 336-345
Correction: Corrigendum: Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis

Lina Sun
Zhiwen Fan
Yong Xu
Amendments and CorrectionsOpen Access27 Jul 2016
Scientific Reports

Volume: 6, P: 1
Serum lipid profiles and risk of colorectal cancer: a prospective cohort study in the UK Biobank

Zhe Fang
Mingming He
Mingyang Song
ResearchOpen Access03 Nov 2020
British Journal of Cancer

Volume: 124, P: 663-670
The tea plant reference genome and improved gene annotation using long-read and paired-end sequencing data

Enhua Xia
Fangdong Li
Xiaochun Wan
ResearchOpen Access15 Jul 2019
Scientific Data

Volume: 6, P: 1-9

Search

Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunotherapy

Library-based virtual match-between-runs quantification in GlyPep-Quant improves site-specific glycan identification

Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone

Screening of F-containing electrolyte additives and clarifying their decomposition routes for stable Li metal anodes

Efficacy of High-intensity Statin Use for Transient Ischemic Attack Patients with Positive Diffusion-weighted Imaging

The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes

Metal artifact reduction through MVCBCT and kVCT in radiotherapy

Publisher Correction: The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes

Retraction Note: A switch in the poly(dC)/RmlB complex regulates bacterial persister formation

Glyco-Decipher enables glycan database-independent peptide matching and in-depth characterization of site-specific N-glycosylation

CAR-T cell therapy-related cytokine release syndrome and therapeutic response is modulated by the gut microbiome in hematologic malignancies

Bioinspired ultra-stretchable and anti-freezing conductive hydrogel fibers with ordered and reversible polymer chain alignment

Author Correction: CAR-T cell therapy-related cytokine release syndrome and therapeutic response is modulated by the gut microbiome in hematologic malignancies

HBV reactivation in patients with chronic or resolved HBV infection following BCMA-targeted CAR-T cell therapy

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction

Epirubicin induces cardiotoxicity through disrupting ATP6V0A2-dependent lysosomal acidification and triggering ferroptosis in cardiomyocytes

A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands

RETRACTED ARTICLE: A switch in the poly(dC)/RmlB complex regulates bacterial persister formation

Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis

Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

Preoperative comprehensive risk estimation for axillary lymph node metastasis in breast cancer: development and verification of a network-based prediction model

Cardiac-specific overexpression of Ndufs1 ameliorates cardiac dysfunction after myocardial infarction by alleviating mitochondrial dysfunction and apoptosis

Combining Sentinel-2 and diverse environmental data largely improved aboveground biomass estimation in China’s boreal forests

Cytotoxic glutarimide-containing polyketides isolated from Streptomyces sp. JCM 4793

Ferroptosis is involved in focal segmental glomerulosclerosis in rats

Epigenetic regulation of lung cancer cell proliferation and migration by the chromatin remodeling protein BRG1

MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response

Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity

Heterologous expression of the TaPI-PLC1-2B gene enhanced drought and salt tolerance in transgenic rice seedlings

Correction: Corrigendum: Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis

Serum lipid profiles and risk of colorectal cancer: a prospective cohort study in the UK Biobank

The tea plant reference genome and improved gene annotation using long-read and paired-end sequencing data

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