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Anthropogenic activities pose threats to riverine fish communities and result in reduced yields. However, this study shows that biodiversity and habitat complexity can buffer human impacts and help stabilize fish communities across spatial scales.

All-inorganic perovskite solar cells promise strong stability but still suffer from moisture-driven surface damage and limited efficiency. Zhang et al. form a one-dimensional/three-dimensional interface using a tailored salt to stabilize the material and boost performance.

Li, Tao, and colleagues present epi-Patho-DBiT to spatially map chromatin accessibility and histone modifications in archived human lymphoma tissues, revealing epigenetic drivers of lymphoma development, progression and transformation.

2D In₂Se₃ holds potential for 2D electronic devices, but its large-scale synthesis is challenging. The authors report the low-temperature deposition of wafer-scale non-ferroelectric κ-phase In₂Se₃ thin films and the fabrication of n-type transistor arrays, showing an average mobility of 39 cm²/Vs and on/off ratios of ≈10⁸.

Ma et al. report a laser polishing and surface reconstruction strategy to improve the surface quality of micron-thick Pb-Sn narrow-bandgap perovskites, enabling single-junction and all-perovskite tandem solar cells with efficiencies of 23.47% (certified) and 29.80%, respectively, by the antisolvent-free method.

James Webb Space Telescope observations show powerful high-redshift quasar outflows, supporting quasar feedback as a key mechanism driving rapid star-formation quenching in early massive galaxies.

Persistent luminescence is promising for photodynamic therapy in deep-seated tumors, but the uncontrollability of light within the body complicates precise spatiotemporal regulation. Here, the authors report X-ray preactivated elimusertib-loaded tumor-targeted photodynamic nanoparticles with controllable “on-off-on” afterglow properties for the treatment of deep-seated tumors.

A shift in organic carbon to total phosphorus (C_org/P_total) ratios in marine siliciclastic strata from approximately 455 million years ago suggests an earlier-than-previously-thought spread of land plants and their impact on the Earth system, based on analogy with extant C/P ratios of terrestrial and marine organic matter.

Functionalizing unactivated carbon–hydrogen bonds is a powerful and atom efficient method to introduce functionality into a molecule. Here, the authors show activation and intramolecular amination of primary C–H bonds using a silver catalyst.

Toxicity of antibody drug conjugates (ADCs) is often caused by off-target shedding of therapeutic payloads due to linker instability. Here, the authors demonstrate that site-specific ligase-dependent conjugation of therapeutic payloads to engineered trastuzumab via a ring-opening linker improves stability compared to conventional HER2- targeting ADCs.

Influenza virus ribonucleoprotein complexes (RNPs) are essential for replication and transcription. Here, authors solve the cryo-EM structure of influenza mini-vRNP to reveal detailed FluPol–NP–RNA coupling and suggest a conformational shift in RNPs during the viral life cycle.

DBiTplus represents an integrated experimental and computational workflow that unifies sequencing-based and imaging-based spatial omics, demonstrated by combining transcriptomic profiling and multiplexed protein imaging on the same tissue section.

A mitochondrion-localised BAHD acyltransferase (3β-tigloyloxytropane synthase, TS) from Atropa belladonna is responsible for the formation of 3β-tigloyloxytropane, the key intermediate in calystegine biosynthesis.

A mechano-intelligent transmission mechanism based on the slipknot delivers precise force signals for clinical practice and robotic operations such as minimally invasive surgery and tendon-driven robotics.

A deep generative model is developed for de novo molecular design and optimization by leveraging electron density. Wet-laboratory assays validated its reliability to generate diverse bioactive molecules—orthosteric and allosteric, inhibitors and activators.

Developing anti-gout medications that simultaneously reduce uric acid and exert anti-inflammatory effects is of interest for managing gout progression. Here, the authors employ a dual-target pharmacophore model to design derivatives of β-carboline-1-propionic acid and identify a drug candidate demonstrating potent uric acid-lowering activity in male hyperuricemia mouse models and mitigating NLRP3-mediated inflammation.

A high-resolution global climate simulation of tidally locked rocky planets orbiting around M dwarfs with explicit convection resolves the behaviour of their clouds, determining the cloud properties and suggesting the frequent appearance of cloud streets affecting the planetary energy balance.

The tailoring of reticular materials is key for enhancing the complexity and diversity of their structure and function. Now, a series of isomeric pillar-layered metal–organic frameworks with tunable topologies have been prepared through altering the layer stacking, which enables variability on the backbone structure, pillar spatial arrangements and pore structure.

Wearable sensors typically require innovative methods of energy harvesting for low-power electronics. Here, the authors present an adaptive power management system with a trimodal energy harvesting approach.

Full-color and high-resolution micro-quantum dot light emitting diodes (Micro-QLED) panel is fabricated by combining blue Micro-QLED electroluminescence (EL) device and red-green quantum dot color converter (QDCC).

Xiao et al. characterize 19 previously unidentified IscB proteins, 10 of which show activity in mammalian cells. They engineer one of the proteins into a robust in vivo genome-editing tool with a broad target-adjacent motif scope and further develop it into a base editor.

The development of the fruiting body (perithecium) in ascomycete fungi involves sexual differentiation processes. Here, the authors show that a non-pheromone receptor, Gip1, regulates two early stages of sexual differentiation in the wheat scab fungus Fusarium graminearum by activating cAMP signaling and Gpmk1 pathways.

Oxidative damage to intracellular membrane proteins is critical to cells. Here, the authors use a water-oxidizing photocatalyst, generating ∙OH even under hypoxia, to show that membrane-specific protein oxidation triggers pyroptosis via non-canonical inflammasomes.

Comparative analyses of rice centromeres from 70 high-quality genomes of the Oryza AA group provide insights into rice centromere evolution and genetic factors that shape these genomic regions.

The use of a new hole transport material called spiro-Naph allows the realization of efficient large-area perovskite solar cells.

Non-Abelian band topology reveals the global quantum geometry of multiple Bloch bands and unveils a new paradigm for topological physics. Here, authors find rich T-broken non-Abelian topological phases and their transitions with an unexpected connection to multigap antichiral edge states.

A key feature of the evolutionary transformation of grass cell walls is the cross-linking of interwoven arabinoxylans via ferulate units. This study discovered an unexpected sucrose ferulate cycle that mediates the feruloylation of arabinoxylan.

Population analysis of 516 wild and domesticated broomcorn millet genomes and a graph-based pangenome based on de novo assemblies of 32 representative accessions identify genomic variations associated with domestication traits.

CO₂ hydrogenation has attracted intense scientific attention yet suffers from the disadvantage of poor activity and low selectivity. Here, the authors report that Cu single atom catalysts with tailored coordination environments on C₃N₄ serve as highly selective catalysts for CO₂ hydrogenation.

Bacterial invasion can lead to multiple host cell responses. Here, the authors show that in a model of uropathogenic E. coli, RhoB is upregulated and induces autophagosome formation in a complex with Beclin1 and Hsp90, promoting bacterial clearance.

The inclusion of platinum-group metals for CO2 reduction electrocatalyst design may trigger the unwanted hydrogen evolution reaction. However, here the authors show that single-atom Pd and Pt on facet-selective Cu can selectively boost CO2 to CH4 or C2H4 conversion through dual-site pathways.

Elevated type 2 functionality in CAR T cell infusion products is significantly associated with maintenance of a median B cell aplasia duration of 8.4 years in paediatric patients with acute lymphocytic leukaemia.

By engineering the crystallization process of Sn–Pb mixed perovskite films, all-perovskite tandem solar cells fabricated using an antisolvent-free method deliver a certified power conversion efficiency of 28.87% and retain 87% of this efficiency after 450 h of operation.

Inflammatory monocytes in the brain meninges promote stress-induced fear behaviour, and the pathways involved can be modulated using psychedelic compounds.

Phototherapy of deep tumors suffers from many obstacles, such as limited near-infrared tissue penetration depth and low accumulation efficiency within the target sites. Here, the authors report stimuli sensitive tumor-targeted photodynamic nanoparticles with persistent luminescence for the treatment of deep tumors.

Analysis of 4,578 Mycobacterium tuberculosis isolates reveals the evolutionary history of the four tuberculosis genotypes in China, from emergence 1,000 years ago to expansion, population peaks and, more recently, dominance of the indigenous sublineage L2.3.

A positive relationship between carbonate weathering and vegetation greenness has been found, indicating a greening Earth has reversed the trend of decreasing weathering under the warming climate. Therefore, future vegetation restoration is important for carbon capture by mineral weathering.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

Liu et al., report extensive maps of chromatin interactions, single-cell expression, and other molecular features in human arterioles and uncover mechanisms linking noncoding genetic variants to gene expression and the development of hypertension.

Using JWST, more than 40 individual stars have been detected in a distant galaxy, dating back to when the Universe was only half of its current age. The stars appear to be red (super)giants that are magnified by factors of hundreds.