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Showing 1–7 of 7 results
Advanced filters: Author: Nathan E. Reticker-Flynn Clear advanced filters

  • Interactions of cells with extracellular matrix are important in normal physiology and cancer metastasis. Here, an extracellular matrix molecule array is developed and used to show that conserved changes in adhesive properties are associated with metastasis, including binding to fibronectin in combination with galectin-3, galectin-8 or laminin.

    • Nathan E. Reticker-Flynn
    • David F. Braga Malta
    • Sangeeta N. Bhatia
    Research
    Nature Communications
    Volume: 3, P: 1-12

  • The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.

    • Xiangyue Zhang
    • Christopher S. McGinnis
    • Edgar G. Engleman
    Research
    Nature
    Volume: 650, P: 470-480

  • Microorganisms in the human gut can affect immune-system cells. Gut bacterial strains have been discovered that boost immune cells that have cell-killing capacity and that can target cancer and protect against infection.

    • Nathan E. Reticker-Flynn
    • Edgar G. Engleman
    News & Views
    Nature
    Volume: 565, P: 573-574

  • Cytokines are immune signaling molecules that are frequently dysregulated in disease. Here, the authors create engineered cytokine ‘adaptors,’ molecular switches that simultaneously block a target cytokine while inducing local activation of alternative cytokine receptors.

    • Gita C. Abhiraman
    • Karsten D. Householder
    • K. Christopher Garcia
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • We provide two procedures to cover distinct approaches for the initiation of lymph node metastases in mice: one for studying the metastatic cascade in tumorigenic cells and the other for studying the effect of metastatic formations in the host.

    • Cort B. Breuer
    • Zhewen Xiong
    • Nathan E. Reticker-Flynn
    Protocols
    Nature Protocols
    Volume: 20, P: 3170-3187