Nature Search

Targeting sorting nexin 3 to treat pulmonary fibrosis by dual modulating Wnt/β-catenin signaling

Dinghu Ma
Wenjing Yu
Jing Lu
ResearchOpen Access15 Jan 2026
Cell Death & Disease

Volume: 17, P: 1-19
Targeting TNK2/ACK1 reverses the immunosuppressive tumor microenvironment and synergizes with immunochemotherapy in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is highly lethal, with treatment effectiveness, including immunotherapy, limited by immunosuppressive tumor microenvironment. This study identifies TNK2/ACK1 as a driver of immune evasion in pancreatic cancer via STAT5A-HVEM signaling that disables CD8⁺ T cells while TNK2 inhibition restores antitumor immunity and synergizes with anti-PD-1 and chemotherapy in PDAC models.

Chao Wu
Weishuai Liu
Jihui Hao
ResearchOpen Access06 Dec 2025
Nature Communications

Volume: 17, P: 1-22
Comprehensive analysis reveals potential therapeutic targets and an integrated risk stratification model for solitary fibrous tumors

Solitary fibrous tumours are mesenchymal tumours with an unpredictable progression and current medical treatments for relapsed SFTs remain ineffective. Here, the authors identified potential therapeutic targets and risk factors for SFTs and created an integrated risk model using 101 patients, and validated in 3 independent cohorts to successfully predict tumour progression.

Renjing Zhang
Yang Yang
Ziming Du
ResearchOpen Access18 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Retraction Note: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis

Chongbiao Huang
Hui Li
Jihui Hao
Amendments and CorrectionsOpen Access02 Jan 2026
Signal Transduction and Targeted Therapy

Volume: 11, P: 1
Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression

Breast cancer cells interact with cancer-associated adipocytes in the microenvironment. Here, the authors report that the cross-talk between these two cell types is dependent on Zeb1, which remodels the tumor-associated adipose microenvironment to confer breast cancer progression.

Lixia Cao
Wei Sun
Shuang Yang
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-22
Mapping gender patterns in “dynamic cultural spaces”: the case of Beijing’s open-air antiques “ghost market” at Panjiayuan

Guanliang Liu
Peiqing Cao
Mathew P. White
ResearchOpen Access19 Jul 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-16
Overactive Neuronal eEF2K/eEF2 signaling is associated with cognitive impairment and apathy-like behavior

Hannah M. Jester
Noelle Nicol
Tao Ma
ResearchOpen Access14 Dec 2025
Molecular Psychiatry

P: 1-18
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence

Yingxi Li
Xiyang Li
Yi Shi
ResearchOpen Access29 Nov 2019
Signal Transduction and Targeted Therapy

Volume: 4, P: 1-11
Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1

The transcription factor Zeb1 is known to promote tumorigenesis and stemness in breast cancer. Here the authors show that tumor endothelial Jagged1 induces activation of Notch1 signaling and increases Zeb1 expression in neighboring breast cancer stem cells, promoting tumor aggressiveness.

Huimin Jiang
Chen Zhou
Shuang Yang
ResearchOpen Access12 Oct 2020
Nature Communications

Volume: 11, P: 1-16
Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment

Chengxiang Xia
Tongjie Wang
Jinyong Wang
Research24 Feb 2020
Leukemia

Volume: 34, P: 2375-2383
Giant room temperature electrocaloric effect in a layered hybrid perovskite ferroelectric: [(CH₃)₂CHCH₂NH₃]₂PbCl₄

Most known electrocaloric materials show relatively poor cooling performance near room temperature, hindering their applications. Here, the authors achieve large electrocaloric effect near room temperature in a hybrid perovskite ferroelectric, useful for high-performance solid-state refrigeration.

Xitao Liu
Zhenyue Wu
Junhua Luo
ResearchOpen Access24 Sept 2021
Nature Communications

Volume: 12, P: 1-7
Breast cancer cell-derived adrenomedullin confers cancer-associated adipose remodeling through the cAMP/Creb1/Zeb1 axis

Xiao Chen
Lixia Cao
Shuang Yang
Research06 Oct 2025
British Journal of Cancer

Volume: 133, P: 1815-1828
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

Under conditions of energy starvation, the p38β–PRAK pathway is activated and inhibits mTORC1 by phosphorylating the small GTPase Rheb. This finding links a major stress response pathway with energy homeostasis.

Min Zheng
Yan-Hai Wang
Jiahuai Han
Research20 Feb 2011
Nature Cell Biology

Volume: 13, P: 263-272
Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus

Aymeric de Parseval
Udayan Chatterji
John H Elder
Research12 Dec 2004
Nature Structural & Molecular Biology

Volume: 12, P: 60-66
Small protein ERSP encoded by LINC02870 promotes triple negative breast cancer progression via IRE1α/XBP1s activation

Xiaolu Wang
Qianqian Wang
Junjian Wang
Research11 Jan 2025
Cell Death & Differentiation

Volume: 32, P: 1014-1025
Targeting autophagy peptidase ATG4B with a novel natural product inhibitor Azalomycin F4a for advanced gastric cancer

Lin Zhong
Bin Yang
Junjian Wang
ResearchOpen Access18 Feb 2022
Cell Death & Disease

Volume: 13, P: 1-13
Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3

Jing Lu
Suowen Xu
Peiqing Liu
Research04 May 2021
Cell Death & Differentiation

Volume: 28, P: 2871-2887
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity

Wenwei Luo
Jingyan Li
Zhuoming Li
ResearchOpen Access26 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-13
Correction to: TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways

Wenzhi Shen
Renle Du
Rong Xiang
Amendments and CorrectionsOpen Access04 Mar 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-2
Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis

Chongbiao Huang
Hui Li
Jihui Hao
Amendments and CorrectionsOpen Access05 Jan 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1
Correction: MZF1 mediates oncogene-induced senescence by promoting the transcription of p16^INK4A

Dan Wu
Hua Tan
Peiqing Sun
Amendments and Corrections29 Nov 2024
Oncogene

Volume: 44, P: 272-275
Tumor-derived interleukin 35 mediates the dissemination of gemcitabine resistance in pancreatic adenocarcinoma

Huizhi Sun
Yi Ge
Chongbiao Huang
Research20 Jan 2024
Oncogene

Volume: 43, P: 776-788
Profile distribution of soil moisture response to precipitation on the Pisha sandstone hillslopes of China

Pan Zhang
Peiqing Xiao
Weiying Sun
ResearchOpen Access04 Jun 2020
Scientific Reports

Volume: 10, P: 1-10
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

The authors report that the cGAS–STING pathway drives a form of autophagy that is independent of interferon induction and distinct from the conventional autophagy.

Xiang Gui
Hui Yang
Zhijian J. Chen
Research06 Mar 2019
Nature

Volume: 567, P: 262-266
Correction to: CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism

Zhen Zhang
Jianjun Li
Shuang Yang
Amendments and CorrectionsOpen Access19 Jun 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1
RETRACTED ARTICLE: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis

Chongbiao Huang
Hui Li
Jihui Hao
ResearchOpen Access14 Jul 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-12
ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM

Xiang Zhang
Zhen Zhang
Shuang Yang
ResearchOpen Access19 Jan 2018
Cell Death & Disease

Volume: 9, P: 1-15
Ultrafast near-infrared pyroelectric detector based on inhomogeneous plasmonic metasurface

We propose a plasmonic effect-assisted pyroelectric detector covered by an inhomogeneous Al metasurface, which exhibits ultrafast response speed and extended near-infrared response spectrum.

Youyan Lu
Liyun Liu
Xiaoyi Liu
ResearchOpen Access06 Sept 2024
Light: Science & Applications

Volume: 13, P: 1-10
Correction to: Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2

Guanwen Wang
Juan Wang
Peiqing Sun
Amendments and Corrections10 Feb 2021
Oncogene

Volume: 40, P: 2335
The toxic effects of electronic cigarette aerosol and cigarette smoke on cardiovascular, gastrointestinal and renal systems in mice

Aijing Xu
Kun Duan
Jianwen Chen
ResearchOpen Access31 Jul 2023
Scientific Reports

Volume: 13, P: 1-14
CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism

Zhen Zhang
Jianjun Li
Shuang Yang
ResearchOpen Access11 Mar 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-13
Glucocorticoid activates STAT3 and NF-κB synergistically with inflammatory cytokines to enhance the anti-inflammatory factor TSG6 expression in mesenchymal stem/stromal cells

Peiqing Huang
Rongrong Sun
Yufang Shi
ResearchOpen Access18 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-9
Correction: CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism

Zhen Zhang
Jianjun Li
Shuang Yang
Amendments and CorrectionsOpen Access04 Oct 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-3
Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation

Liang Lu
Sulin Zhang
Xiaoyan Shen
ResearchOpen Access11 May 2017
Cell Death & Disease

Volume: 8, P: e2767
MZF1 mediates oncogene-induced senescence by promoting the transcription of p16^INK4A

Dan Wu
Hua Tan
Peiqing Sun
Research12 Nov 2021
Oncogene

Volume: 41, P: 414-426
TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness

Renle Du
Wenzhi Shen
Yunping Luo
ResearchOpen Access13 Dec 2019
Signal Transduction and Targeted Therapy

Volume: 4, P: 1-12
Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2

Guanwen Wang
Juan Wang
Peiqing Sun
Research28 Sept 2020
Oncogene

Volume: 39, P: 7034-7050
Her2 promotes early dissemination of breast cancer by suppressing the p38-MK2-Hsp27 pathway that is targetable by Wip1 inhibition

Juan Wang
Guanwen Wang
Peiqing Sun
Research26 Aug 2020
Oncogene

Volume: 39, P: 6313-6326
WIP1 promotes cancer stem cell properties by inhibiting p38 MAPK in NSCLC

Kaiyuan Deng
Liang Liu
Peiqing Sun
ResearchOpen Access15 Apr 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-10
miR-30 disrupts senescence and promotes cancer by targeting both p16^INK4A and DNA damage pathways

Weijun Su
Lixin Hong
Peiqing Sun
Research15 Jun 2018
Oncogene

Volume: 37, P: 5618-5632
TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways

Wenzhi Shen
Renle Du
Rong Xiang
ResearchOpen Access22 Jul 2016
Signal Transduction and Targeted Therapy

Volume: 1, P: 1-10
Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors

Rongqun Guo
Fangxiao Hu
Jinyong Wang
ResearchOpen Access15 Nov 2019
Cell Research

Volume: 30, P: 21-33
ZEB1 induces ER-α promoter hypermethylation and confers antiestrogen resistance in breast cancer

Jianbo Zhang
Chen Zhou
Shuang Yang
ResearchOpen Access06 Apr 2017
Cell Death & Disease

Volume: 8, P: e2732
Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy

Ying Gao
Yajun Liu
Min Li
ResearchOpen Access11 Aug 2016
Cell Death & Disease

Volume: 7, P: e2330
TGFBR1*6A as a modifier of breast cancer risk and progression: advances and future prospects

Kojo Agyemang
Allan M. Johansen
Boris Pasche
ReviewsOpen Access19 Jul 2022
npj Breast Cancer

Volume: 8, P: 1-9

Search

Filter By:

Search

Quick links