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Showing 1–12 of 12 results
Advanced filters: Author: Pengchen Ma Clear advanced filters

  • An RNA codon-expansion strategy enables incorporation of non-canonical amino acids into proteins of interest orthogonally to existing methods by inserting pseudouridine codons into specific mRNA transcripts and using an engineered decoder tRNA.

    • Jiangle Liu
    • Xueqing Yan
    • Peng R. Chen
    Research
    Nature
    Volume: 643, P: 1410-1420

  • Chiral lactams are important pharmacophores and strategies for their synthesis through direct C–H functionalization are highly sought after. Now, intramolecular C–H amidation of dioxazolones via biocatalytic nitrene transfer enables the synthesis of enantioenriched lactams with various ring sizes.

    • Satyajit Roy
    • David A. Vargas
    • Rudi Fasan
    Research
    Nature Catalysis
    Volume: 7, P: 65-76

  • Pseudokinases are non-canonical protein-kinase-like proteins deficient in kinase activity, few of which have enzymatic activity that differs from phosphorylation. Now a pseudokinase-enabled cyclization activity for the biosynthesis of ribosomally synthesized and post-translationally modified peptides has been observed. Here pseudokinases can catalyse a Michael addition for (ene)thioether crosslinking through a sandwich-like substrate-assisted process.

    • Ling Hu
    • Miao Li
    • Wen Liu
    Research
    Nature Chemistry
    Volume: 18, P: 152-163

  • The condensation domains of non-ribosomal peptide synthetases use a concerted reaction mechanism in which the active site histidine probably serves as a crucial stabilizing hydrogen bond acceptor for the developing ammonium.

    • Angelos Pistofidis
    • Pengchen Ma
    • T. Martin Schmeing
    Research
    Nature
    Volume: 638, P: 270-278

  • A new pyrrolysyl-tRNA synthetase/PyltRNA (PylRS/PyltRNA) pair that is mutually orthogonal to existing PylRS/PyltRNA pairs has now been discovered and optimized. This system could enable the site-specific incorporation of a greater number of distinct non-canonical amino acids into a protein.

    • William S. C. Ngai
    • Peng R. Chen
    News & Views
    Nature Chemistry
    Volume: 10, P: 802-803

  • A deep-learning-based strategy is used to design artificial luciferases that catalyse the oxidative chemiluminescence of diphenylterazine with high substrate specificity and catalytic efficiency.

    • Andy Hsien-Wei Yeh
    • Christoffer Norn
    • David Baker
    ResearchOpen Access
    Nature
    Volume: 614, P: 774-780

  • In situ profiling of lysosomal proteomes is impeded by the acidic and digestive environment of lysosomes. Now, a bioorthogonal photocatalytic system (CAT-Lyso) is developed that is compatible with these conditions, enabling the proximity labelling of lysosomal proteomes within living cells.

    • Yan Zhang
    • Ziqi Liu
    • Xinyuan Fan
    Research
    Nature Catalysis
    Volume: 8, P: 162-177

  • As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?” — here is what they said.

    • Lona M. Alkhalaf
    • Cheryl Arrowsmith
    • Georg Winter
    Special Features
    Nature Chemical Biology
    Volume: 21, P: 6-15