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Here, the authors present a high-throughput genetic screen to identify genes that regulate human myoblast fusion.

Here, the authors investigate the molecular role of the CHAMP1 gene/protein in preclinical models of human muscle development and disease.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Here, the authors structurally and biochemically characterise the YcfA-YcfC enzyme system, crucial for biosynthesis of the anticancer and antimicrobial agent 6-thioguanine.

Complex molecule synthesis involves speculative retrosynthetic planning and resource-intensive experimental evaluation. Now, a complementary strategy is reported that combines human-generated synthetic plans with computational prediction to accelerate this process. A machine learning model was trained to predict the yield of radical cyclization and guide the syntheses of clovane sesquiterpenoids.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The kinase Lkb1 is expressed in various metabolic tissues and is known to regulate cellular and systemic energy homeostasis. Here, the authors delete Lkb1 specifically in mature adipocytes of mice to show that Lkb1 regulates brown adipose tissue expansion and expression of UCP1.

Direct modulation of protein by artificial catalysts as enzyme mimetics remains hindered by the lack of highly efficient catalytic centers. Here, the authors present the development of artificial protein modulators (APROMs) with protein phosphatase-like characteristics, catalytically reprogram the biological function of α-synuclein.

Core-shell designs enhance the luminescence of lanthanide-doped upconversion nanoparticles (UCNPs), but the effect of shell coverage was insufficiently characterized. Here the authors demonstrate, on a series of core-shell UCNPs with various shell coverage ratios, an on-off effect by which luminescence is enhanced only when a full coverage is achieved.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

Comprehensive epigenomic maps of various rice varieties are still unavailable. Here, the authors report the development of eChIP as a fast and low-input upgrade of regular plant ChIP-seq protocol for epigenome analysis of 20 rice varieties and annotate over 80% of the genome with different epigenome properties for transcriptional regulation.

Xu, Lin, Li, Shen, et al. investigate the incidence, risk factors, and molecular mechanisms of VEGF(R) inhibitor-induced arthritis. They find that VEGF(R) inhibitor treatment increases arthritis inflammatory pathway activation in bone.

Membrane distillation can use low-grade heat for salt water desalination, but the materials used can often suffer from limited permeance. Here, a strategy is proposed to construct a pore surface and size functionality gradient in a covalent organic framework, enabling a flux of 600 l m^–2 h^–1 with NaCl rejection of 99.99%.

Retinitis pigmentosa (RP) is the most common type of inherited retinal dystrophy without effective treatments. Here, authors apply prime editing (PE) system to correct the point mutation in a preclinical RP mouse model. In vivo treatment achieves genome editing and restores mice vision.

Here the authors report that a thermophilic archaeal TnpB enables efficient gene editing in the natural host: they see that the TnpB has different TAM requirements for eliciting cell death and for facilitating gene editing. They show that TnpB can be harnessed for flexible single-nucleotide editing with templated repair.

In a prespecified interim analysis of the multicenter, randomized, phase 3 FLAMES trial, maintenance therapy with a PARP inhibitor in patients with ovarian cancer showed prolonged progression-free survival compared with placebo in all subgroups defined by BRCA or homologous recombination status.

In vivo assessment of nuclease off-target activity has primarily been indirect or through ChIP-based detection of double-strand break DNA repair factors, which can be cumbersome. Here, the authors show that GUIDE-tag, enables one-step off-target genome editing analysis in mouse liver and lung.

Multidentate molecular additives are widely used to passivate perovskite, yet the role of chelate effect is still unclear. Here, the authors investigate a wide range of additives with different coordination number and functional moieties to establish correlation between coordination affinity and perovskite crystallisation dynamics.

Enhancing retrosynthetic efficiency requires overcoming the vast complexity of chemical space, the limited known interconversions between molecules, and the challenges posed by limited experimental datasets. Here, the authors introduce generative machine learning methods for retrosynthetic planning that generate reaction templates.

Spatial organization of regulatory elements and its impact on gene expression in plants remain unclear. Here, the authors construct maize chromatin interaction maps using chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) and show their associations with gene expression and agronomic traits.

Achieving bright and efficient blue emission in metal halide perovskite light-emitting diodes has proven to be challenging. Here, the authors demonstrate high EQE and spectrally stable blue light-emitting diodes based on mixed halide perovskites, with emission from 490 to 451 nm by using a vapour-assisted crystallization technique.

The Tibetan plateau is manifested by contrasting along-strike lithospheric structures, but the correlation with multi-terrane configuration remains challenging. Here, the authors show the crucial roles of the original geometric shape of accreted terranes in regulating the lithospheric evolution of Tibetan plateau.

A modular assembly strategy has been demonstrated to construct metal nanoparticles functionalized mesoporous carbon two-dimensional (2D) nanosheets by organizing zero-dimensional (0D) spherical monomicelle modules on the 2D supporting blocks. The resultant materials exhibit an excellent electrocatalytic activity for oxygen reduction reaction, which holds a great potential as a catalyst for fuel cells.

Bottom-up design of functional device components based on nanometer-sized building blocks relies on accurate control of their self-assembly behavior. Here, the authors demonstrate a solvent-mediated polymerization of atom-precise gold–silver nanoclusters into macroscopic single crystals with highly anisotropic p-type semiconducting characteristics.

Hollow UCNPs with tunable cavity size were synthesized, which can be used as ratiometric luminescent thermometers over a wide temperature range.

Modification of RNA with m6A has been shown to be important during spermatogenesis. Here they identify post-transcriptional functions of PRRC2A, showing it promotes transcriptome transition from spermatogonia to spermatocytes and the translation of genes related to cell division.

A solution-processed perovskite diode that functions as both optical transmitter and receiver can be used to build a monolithic pulse sensor and a bidirectional optical communication system.

Three new red-excitable monomeric fluorescent proteins obtained by structure-guided mutagenesis of mNeptune are described in this work. The authors show the use of one of them, mCardinal, to visualize the differentiation of myoblasts into myocytes in living mice.