Nature Search

Philip D. Lawley (1927–2011)

Chemist who discovered that cancer is caused by damage to DNA.

Stanley Venitt
David H. Phillips
Comments & Opinion01 Feb 2012
Nature

Volume: 482, P: 36
Loss of KDM6A-mediated genomic instability and metabolic reprogramming regulates response to therapeutic perturbations in bladder cancer

Genes encoding key epigenetic regulators, including Lysine Demethylase 6A (KDM6A), are frequently mutated in bladder cancer. Here, the authors show that loss of KDM6A promotes formation of extrachromosomal circular DNA (eccDNA), genomic instability, and metabolic reprogramming, driving resistance to cisplatin chemotherapy while simultaneously enhancing sensitivity to immune checkpoint inhibitors.

Pratishtha Singh
Ranit D’Rozario
Sangeeta Goswami
ResearchOpen Access07 Jan 2026
Nature Communications

P: 1-23
Native diversity buffers against severity of non-native tree invasions

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Camille S. Delavaux
Thomas W. Crowther
Daniel S. Maynard
ResearchOpen Access23 Aug 2023
Nature

Volume: 621, P: 773-781
James Lovelock reflects on Gaia's legacy

Scientist who features in an exhibition opening today in London, talks about Gaia, climate change and whether peer review is necessary.

Philip Ball
News09 Apr 2014
Nature
James Randi (1928–2020)

Illusionist who exposed fraud to showcase the perils of credulity.

Philip Ball
Comments & Opinion29 Oct 2020
Nature

Volume: 587, P: 34
Biological insights into schizophrenia from ancestrally diverse populations

Genome-wide association studies incorporating data for populations of African ancestry provide an expanded view of the genetic basis of schizophrenia, which has previously been studied mainly in European and East Asian cohorts.

Tim B. Bigdeli
Chris Chatzinakos
Panos Roussos
Research21 Jan 2026
Nature

P: 1-10
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

P: 1-18
A water-soluble copolymer for storage and electron conversion in photocatalytic on-demand hydrogen evolution

The study presents a recyclable polymer system that stores solar energy and releases it as hydrogen on demand, offering an efficient and sustainable route for renewable energy storage and fuel generation.

Marco Hartkorn
Robin Kampes
Sven Rau
ResearchOpen Access28 Jan 2026
Nature Communications

Volume: 17, P: 1-8
Developing a complete AI-accelerated workflow for superconductor discovery

Jason B. Gibson
Ajinkya C. Hire
Richard G. Hennig
ResearchOpen Access27 Jan 2026
npj Computational Materials

P: 1-10
Pattern of Synthesis of Deoxyribonucleic Acid in Bacillus Cereus Growing Synchronously out of Spores

I. ELIZABETH YOUNG
PHILIP C. FITZ-JAMES
Research07 Feb 1959
Nature

Volume: 183, P: 372-373
Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 trial

In a randomized phase 2 trial in patients with acute coronary syndrome and high levels of the inflammation biomarker C-reactive protein, treatment with low-dose interleukin-2 increased the numbers of regulatory T cells and reduced arterial inflammation, compared to placebo.

Rouchelle S. Sriranjan-Rothwell
Tian X. Zhao
Leanne Masters
ResearchOpen Access08 Jan 2026
Nature Medicine

P: 1-9
Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study

Vassy, Dornisch and colleagues developed a genomics-based prostate cancer risk model to support a randomized clinical trial of precision screening in a national healthcare system.

Jason L. Vassy
Anna M. Dornisch
Tyler M. Seibert
Research26 Jan 2026
Nature Cancer

P: 1-16
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
NEUROLOGY May 17, 1973, 2:00 P.M. Continental Parlor 7–8

Philip R Dodge
Research01 Apr 1973
Pediatric Research

Volume: 7, P: 57-58
Modelling Hepatic Endoderm Development: Highly Efficient Differentiation of Human Embryonic Stem Cells to Functional Hepatic Endoderm Requires ActivinA and Wnt3a Signalling.

David Hay
Judy Fletcher
John Iredale
ResearchOpen Access10 Jan 2008
Nature Precedings

P: 1
Modelling Hepatic Endoderm Development: Highly Efficient Differentiation of Human Embryonic Stem Cells to Functional Hepatic Endoderm Requires ActivinA and Wnt3a Signalling.

David Hay
Judy Fletcher
John Iredale
ResearchOpen Access26 Dec 2007
Nature Precedings

P: 1
Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial

The R21/Matrix-M vaccine, but not the ME-TRAP vaccine, was protective against intradermal challenge with Plasmodium falciparum sporozoites, while neither was protective against direct venous inoculation, potentially explaining previously observed differences in protection.

Melissa C. Kapulu
Francesca Orenge
Philip Bejon
ResearchOpen Access06 Jan 2026
Nature Medicine

Volume: 32, P: 178-185
Retraction Note: Antibodies against endogenous retroviruses promote lung cancer immunotherapy

Kevin W. Ng
Jesse Boumelha
George Kassiotis
Amendments and CorrectionsOpen Access14 Jan 2026
Nature

Volume: 649, P: 1330
Seismotectonics of the El Asnam earthquake

M. Ouyed
M. Meghraoui
H. Philip
Research02 Jul 1981
Nature

Volume: 292, P: 26-31
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Science must move with the times

Research cannot fulfil its social contract and reach new horizons by advancing on the same footing into the future, argues Philip Ball in the last essay of a series on how the past 150 years have shaped today’s science system, to mark Nature’s anniversary.

Philip Ball
Comments & Opinion05 Nov 2019
Nature

Volume: 575, P: 29-31
A smooth filament origin for distant prolate galaxies seen by JWST and HST

JWST has revealed many prolate, filamentary galaxies at z ≈ 3–8. Hydrodynamical simulations reproduce this trend only in warm or wave dark matter models, where smooth filamentary accretion dominates over the hierarchical fragmentation seen with cold dark matter.

Alvaro Pozo
Tom Broadhurst
Rogier Windhorst
Research08 Dec 2025
Nature Astronomy

P: 1-11
Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis

Sinead King
John O’Connor
Tamsyn E. Van Rheenen
ResearchOpen Access15 Jan 2026
Molecular Psychiatry

P: 1-13
Macromolecular Components of Chlorella Pyrenoidosa

PHILIP NEWMARK
JACK D. STEPHENS
GAIL L. BOWER
Research26 Sept 1959
Nature

Volume: 184, P: 963-965
POSTER SYMPOSIUM: SURFACTANT REPLACEMENT

Philip Ballard
Barry Smith
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 115-116
Maddox by his successor

Philip Campbell
News17 Apr 2009
Nature

Volume: 458, P: 985-986
Effect of climate on traits of dominant and rare tree species in the world’s forests

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Iris Hordijk
Lourens Poorter
Thomas W. Crowther
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-15
An outer membrane vesicle vaccine prevents lung pathology in a macaque model of pneumonic melioidosis

Currently, there is no licensed vaccine for Burkholderia pseudomallei, the causative agent of melioidosis. Here, the authors evaluate the efficacy and safety of an outer-membrane vesicle vaccine in macaques and demonstrate that it prevents lung pathology.

Sarah M. Baker
Erik W. Settles
Lisa A. Morici
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 17, P: 1-12
Comparative evaluation of 5 combination adjuvants on immunogenicity and efficacy of approved seasonal influenza vaccines

Jenny Hernandez-Davies
Jiin Felgner
D. Huw Davies
ResearchOpen Access27 Jan 2026
npj Vaccines

Volume: 11, P: 1-18
Genomic footprints of activated telomere maintenance mechanisms in cancer

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Lina Sieverling
Chen Hong
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-13
Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

Alessandra Eva
Keith C. Robbins
Stuart A. Aaronson
Research14 Jan 1982
Nature

Volume: 295, P: 116-119
An oscillating trend in Phanerozoic non-skeletal carbonate mineralogy

Philip A. Sandberg
Research01 Sept 1983
Nature

Volume: 305, P: 19-22
How the Royal Institution made science a seasonal spectacle

From flaming raisins to robots and rockets, the institution’s Christmas Lectures have educated and entertained for two centuries.

Philip Ball
Comments & Opinion08 Dec 2025
Nature

Volume: 648, P: 267-269
Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV

Using data from the CoVPN 3008 study, the authors show that the neutralizing antibody correlate of risk holds in people living with HIV. However, the nAb correlate was weaker and shorter-lived in a vaccine-immunity versus hybrid-immunity population.

Nonhlanhla N. Mkhize
Bo Zhang
Peter B. Gilbert
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-19
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Ken Suzuki
Konstantinos Hatzikotoulas
Eleftheria Zeggini
ResearchOpen Access19 Feb 2024
Nature

Volume: 627, P: 347-357
Stratigraphic record of Early Eocene Hyopsodus and the geometry of mammalian phylogeny

Philip D. Gingerich
Research08 Mar 1974
Nature

Volume: 248, P: 107-109
The Brain of the Heterostraci (Agnatha)

H. PHILIP WHITING
L. B. HALSTEAD TARLO
Research21 Aug 1965
Nature

Volume: 207, P: 829-831
Genomic basis for RNA alterations in cancer

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Claudia Calabrese
Natalie R. Davidson
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature

Volume: 578, P: 129-136
Metabolic engineering: The concept coalesces

Philip Lessard
Research01 Dec 1996
Nature Biotechnology

Volume: 14, P: 1654-1655
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Clustered arrangement of immunoglobulin λ constant region genes in man

Philip A. Hieter
Gregory F. Hollis
Philip Leder
Research10 Dec 1981
Nature

Volume: 294, P: 536-540
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Yiqun Zhang
Fengju Chen
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-14
Correction: Corrigendum: Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

Miguel A. Lanaspa
Takuji Ishimoto
Richard J. Johnson
Amendments and Corrections04 Dec 2013
Nature Communications

Volume: 4, P: 1
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Is volcanic ash a pneumoconiosis risk?

Francis H. Y. Green
Val Vallyathan
Philip Parshley
Research17 Sept 1981
Nature

Volume: 293, P: 216-217
An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy

Genome-wide analysis in individuals of African ancestry identifies a nonsense variant in CD36 associated with increased risk of dilated cardiomyopathy (DCM), partly accounting for the higher incidence of DCM in African-ancestry populations.

Jennifer E. Huffman
Liam Gaziano
Krishna G. Aragam
ResearchOpen Access31 Oct 2025
Nature Genetics

Volume: 57, P: 2682-2690
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Esther Rheinbay
Morten Muhlig Nielsen
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature

Volume: 578, P: 102-111

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