Nature Search

Slow release devices: STD protection at last?

Robert P. Lanza
William L. Chick
Research01 Apr 1996
Nature Biotechnology

Volume: 14, P: 437-438
Expanding global access to mRNA vaccines

mRNA vaccines combine rapid design, scalable manufacturing and strong safety profiles with applications across infectious diseases, cancer and autoimmune disorders. However, global access to mRNA vaccines remains limited. This Review explores how achieving equitable access depends on overcoming technical, logistical, economic and regulatory barriers through innovations in thermostability, delivery systems, alternative RNA platforms, artificial intelligence-driven design and optimization, and coordinated policy strategies.

Behnaz Eshaghi
Robert Langer
Ana Jaklenec
Reviews26 Mar 2026
Nature Reviews Bioengineering

P: 1-22
Rapid test to detect agents that damage human DNA

ROBERT B. PAINTER
Research17 Feb 1977
Nature

Volume: 265, P: 650-651
Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery

This study introduces the Lipid Nanoparticle Database (LNPDB) and web tool that consolidates lipid nanoparticle structure-function data. LNPDB facilitates molecular dynamics and deep learning approaches to advance data-driven design for nucleic acid delivery.

Evan Collins
Jungyong Ji
Wonpil Im
ResearchOpen Access28 Jan 2026
Nature Communications

Volume: 17, P: 1-14
Towards intelligent and miniaturized drug delivery devices

Intelligent and miniaturized drug delivery devices leveraging advances in biotechnology, artificial intelligence, electronics and materials science enable treatments with increased precision and responsiveness, with applications in cancer, diabetes, cardiovascular disease and other diseases.

Xinwei Wei
John B. Buse
Zhen Gu
Reviews25 Mar 2026
Nature

Volume: 651, P: 897-908
On the tear resistance of skin

It is known that skin has a large tear resistance, but little is known of the mechanism behind this. Here, the authors carry out a structural analysis of rabbit skin to show how the deformation of collagen fibrils in the skin results in a strong resistance to tear propagation.

Wen Yang
Vincent R. Sherman
Marc A. Meyers
ResearchOpen Access27 Mar 2015
Nature Communications

Volume: 6, P: 1-10
Multiple self–healing squamous epitheliomata (ESS1) mapped to chromosome 9q22–q31 in families with common ancestry

David R. Goudie
Martin A.R. Yuille
Malcolm A. Ferguson-Smith
Research01 Feb 1993
Nature Genetics

Volume: 3, P: 165-169
Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy

Cisca Wijmenga
Jane E. Hewitt
Rune R. Frants
Research01 Sept 1992
Nature Genetics

Volume: 2, P: 26-30
Consequences of narrow cyclotron emission from Hercules X–1

ROBERT P. WEAVER
Research10 Aug 1978
Nature

Volume: 274, P: 571-572
Simulation of Bilirubin Detoxification in the Newborn Using an Extracorporeal Bilirubin Oxidase Reactor

Claudy J-P Mullon
Christine M Tosone
Robert Langer
Research01 Nov 1989
Pediatric Research

Volume: 26, P: 452-457
PULMONARY May 17, 1973, 2:00 P.M. Continental Ballroom 6

Robert B Mellins
Research01 Apr 1973
Pediatric Research

Volume: 7, P: 59-168
Action of γ-Aminobutyric Acid on Cancer borealis Muscle

ROBERT S. EISENBERG
DAVID HAMILTON
Research08 Jun 1963
Nature

Volume: 198, P: 1002-1003
Breeding Habits of the Greenland Whale

ROBERT W. GRAY
Research13 Apr 1929
Nature

Volume: 123, P: 564-565
Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons

The delivery of mRNAs into neurons at inflammatory sites in vivo can be enhanced by engineering leucocytes to produce extracellular vesicles incorporating mRNA-packaging retrovirus-like capsids.

Wenchao Gu
Sijin Luozhong
Shaoyi Jiang
Research19 Feb 2024
Nature Biomedical Engineering

Volume: 8, P: 415-426
Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines

This work presents a degradable ionizable lipid, AMG1541, for mRNA vaccines that significantly enhances potency and enables similar protective immunity at doses 100-fold lower than current standards, while also reducing toxicity and improving clearance in vivo.

Arnab Rudra
Akash Gupta
Daniel G. Anderson
Research07 Nov 2025
Nature Nanotechnology

Volume: 20, P: 1831-1842
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events

Marco Guerrini
Daniela Beccati
Ram Sasisekharan
Research23 Apr 2008
Nature Biotechnology

Volume: 26, P: 669-675
Kinetics of the radiative and nonradiative recombination in polar and semipolar InGaN quantum wells

Lucja Marona
Dario Schiavon
Piotr Perlin
ResearchOpen Access27 Jan 2020
Scientific Reports

Volume: 10, P: 1-10
Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci

Disparities in risk and outcomes of pediatric acute lymphoblastic leukemia (ALL) are apparent between different ancestries. Here the authors identify genetic variants with African ancestry-specific risks for developing pediatric B-cell ALL that are also linked to greater 5-year mortality risk.

Cindy Im
Andrew R. Raduski
Logan G. Spector
ResearchOpen Access22 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Oxygen control of cytochrome c oxidase synthesis in isolated mitochondria from Saccharomyces cerevisiae

GERT S. P. GROOT
ROBERT O. POYTON
Research15 May 1975
Nature

Volume: 255, P: 238-240
Oral immunization with an anti–idiotypic antibody to the exoglycolipid antigen protects against experimental Chlamydia trachomatis infection

Judith A. Whittum-Hudson
Ling-Ling An
A. Bruce Macdonald
Research01 Oct 1996
Nature Medicine

Volume: 2, P: 1116-1121
Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo

Michael Simons
Elazer R. Edelman
Robert D. Rosenberg
Research03 Sept 1992
Nature

Volume: 359, P: 67-70
A tough biodegradable elastomer

Yadong Wang
Guillermo A. Ameer
Robert Langer
Research01 Jun 2002
Nature Biotechnology

Volume: 20, P: 602-606
Multi-pulse drug delivery from a resorbable polymeric microchip device

Amy C. Richards Grayson
Insung S. Choi
Robert Langer
Research19 Oct 2003
Nature Materials

Volume: 2, P: 767-772
Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines

Chun Wang
Qing Ge
David Putnam
Research15 Feb 2004
Nature Materials

Volume: 3, P: 190-196
Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation

Gastrointestinal motility disorders affect over 20% of the population, yet current therapies provide limited relief. Here, the authors show that in a swine model a closed-loop GI neuroprosthesis restores peristalsis and enhances metabolic responses via targeted electrical and chemical stimulation

Shriya Srinivasan
Marc-Joseph Antonini
Giovanni Traverso
ResearchOpen Access10 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice

Sepsis may progress into lethal septic shock, but the cellular mechanisms are still unclear. Here the authors show that, in septic mice, platelets activate perivascular mast cells to cause systemic hypotension and vascular pathology, while inhibiting platelets or mast cell activation suppresses septic shock induction, thereby implicating potential therapy targets.

Hae Woong Choi
Joo Hwan Noh
Jörn Karhausen
ResearchOpen Access03 Dec 2025
Nature Communications

Volume: 17, P: 1-15
Engineered prime editors with minimal genomic errors

Engineered prime editor systems with reduced occurrences of unwanted insertions or deletions during genome editing are developed.

Vikash P. Chauhan
Phillip A. Sharp
Robert Langer
ResearchOpen Access17 Sept 2025
Nature

Volume: 646, P: 1254-1260
Controlled release of a therapeutic protein

Lyophilized macromolecules complexed with zinc and encapsulated within degradable microspheres are slowly released for at least one month (pages 795–799).

Robert Langer
News & Views01 Jul 1996
Nature Medicine

Volume: 2, P: 742-743
The potential of miniaturized ingestible electronics

Ingestible electronic devices could transform gastrointestinal medicine by combining diagnostic and therapeutic functions into a single miniature device. But challenges related to device miniaturization, power-efficient integrated circuit design and data security remain to be addressed.

Giovanni Traverso
Paul Sheehan
Anantha Chandrakasan
Comments & Opinion30 Jan 2026
Nature Electronics

Volume: 9, P: 5-7
A personal account of translating discoveries in an academic lab

Robert Langer shares the experiences and lessons learned through his involvement with more than two dozen biotech startups.

Robert Langer
Comments & Opinion10 Jun 2013
Nature Biotechnology

Volume: 31, P: 487-489
A coastal coccolithophore maintains pH homeostasis and switches carbon sources in response to ocean acidification

Calcifying species have diverse responses to ocean acidification, but the underlying mechanisms are not well-constrained. Here, Liu et al. show that O. neapolitana maintains its calcification site pH and utilizes more CO₂ compared to HCO₃⁻ to support its growth under high-CO₂ conditions.

Yi-Wei Liu
Robert A. Eagle
Justin B. Ries
ResearchOpen Access20 Jul 2018
Nature Communications

Volume: 9, P: 1-12
Perspective: Special delivery for the gut

Wanted: biomaterials for a risky journey. Giovanni Traverso and Robert Langer explain the gastrointestinal frontier.

Giovanni Traverso
Robert Langer
Comments & Opinion25 Mar 2015
Nature

Volume: 519, P: S19
Extremely strong carbon monoxide emission from the Cloverleaf quasar at a redshift of 2.5

Richard Barvainis
Linda Tacconi
Paul Coleman
Research13 Oct 1994
Nature

Volume: 371, P: 586-588
A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines

Automated fabrication of microneedle patch mRNA vaccines for COVID-19 may improve vaccine access.

Aurélien vander Straeten
Morteza Sarmadi
Ana Jaklenec
Research24 Apr 2023
Nature Biotechnology

Volume: 42, P: 510-517
Adrenocortical tissue formed by transplantation of normal clones of bovine adrenocortical cells in scid mice replaces the essential functions of the animals' adrenal glands

Michael Thomas
S. Robert Northrup
Peter J. Hornsby
Research01 Sept 1997
Nature Medicine

Volume: 3, P: 978-983
Reconstructing the early evolution of Fungi using a six-gene phylogeny

Timothy Y. James
Frank Kauff
Rytas Vilgalys
Research19 Oct 2006
Nature

Volume: 443, P: 818-822
Targets of homeotic gene control in Drosophila

Alex P. Gould
Jenny J. Brookman
Robert A. H. White
Research22 Nov 1990
Nature

Volume: 348, P: 308-312
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy

A deep-learning method designs lipid nanoparticles that deliver mRNA to the ferret lung.

Jacob Witten
Idris Raji
Daniel G. Anderson
Research10 Dec 2024
Nature Biotechnology

Volume: 43, P: 1790-1799
Degradable poly(β-amino ester) microparticles for cleansing products and food fortification

This study reports the preparation of degradable poly(β-amino ester) microparticles as a promising replacement for nondegradable microplastics in cleansing products and food fortification, demonstrating effective cleansing, toxic element removal and robust nutrient protection with efficient release.

Linzixuan Zhang
Ruiqing Xiao
Ana Jaklenec
ResearchOpen Access06 Dec 2024
Nature Chemical Engineering

Volume: 2, P: 77-89
An elastic second skin

A skin-conforming crosslinked polymer layer formulated for easy topical application mimics the properties of normal, youthful skin and improves the appearance of herniated lower eyelid fat pads.

Betty Yu
Soo-Young Kang
Robert Langer
Research09 May 2016
Nature Materials

Volume: 15, P: 911-918
Emergency delivery of particulate drugs by active ejection using in vivo wireless devices

A wireless, minimally invasive emergency rescue device is developed for the active burst-release of stable particulate forms of peptide and hormone drugs into subcutaneous sites in mice.

Siddharth R. Krishnan
Laura O’Keeffe
Daniel G. Anderson
Research09 Jul 2025
Nature Biomedical Engineering

Volume: 10, P: 144-160
Polymers for the sustained release of proteins and other macromolecules

ROBERT LANGER
JUDAH FOLKMAN
Research28 Oct 1976
Nature

Volume: 263, P: 797-800
Agonist regulation of the human platelet α-adrenergic receptor

BARRY COOPER
ROBERT I. HANDIN
R. WAYNE ALEXANDER
Research17 Aug 1978
Nature

Volume: 274, P: 703-706
Isolation of a biologically active macrophage receptor for the third component of complement

Robert J. Schneider
Anthony Kulczycki Jr
John P. Atkinson
Research30 Apr 1981
Nature

Volume: 290, P: 789-792
mRNA therapy at the convergence of genetics and nanomedicine

Since the early 1990s, the intersection of genetics and nanomedicine has found a home in the clinic as one of the game changers of the past decade, holding great promise in fighting diseases by rapidly developing much-needed therapeutic platforms, from cancer to infectious or genetic diseases. And this revolution was just triggered by the amazing evolving world of messenger RNA and its ‘cues’.

João Conde
Robert Langer
José Rueff
Comments & Opinion17 Mar 2023
Nature Nanotechnology

Volume: 18, P: 537-540
Two-dimensional chiral crystals of phospholipid

Robert M. Weis
Harden M. McConnell
Research05 Jul 1984
Nature

Volume: 310, P: 47-49
Effect of precipitation on the albedo susceptibility of clouds in the marine boundary layer

Robert Pincus
Marcia B. Baker
Research17 Nov 1994
Nature

Volume: 372, P: 250-252
On-patient medical record and mRNA therapeutics using intradermal microneedles

Intradermal microneedles for the co-delivery of mRNA and near-infrared fluorescent microparticles are used in combination with deep learning-based image analysis for the simultaneous administration of therapeutics and registry of patient information records into the skin.

Jooli Han
Maria Kanelli
Ana Jaklenec
ResearchOpen Access24 Feb 2025
Nature Materials

Volume: 24, P: 794-803
Boosting hydrogel conductivity via water-dispersible conducting polymers for injectable bioelectronics

Injectable bioelectronics face low conductivity due to poor polymer dispersibility. Here, authors engineer dopants in conductive polymers to boost their water dispersibility 5-fold and conductivity 20-fold, enabling biodegradable, 3D-printable hydrogels for wearables and implantable devices.

Hossein Montazerian
Elham Davoodi
Wei Gao
ResearchOpen Access22 Apr 2025
Nature Communications

Volume: 16, P: 1-15
Cataclysmic conferences show convergence

Robert P. Harkness
Brian McMahon
News & Views29 May 1980
Nature

Volume: 285, P: 286-287

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