Search

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Authors evaluate and present the safety and immunogenicity results of an influenza vaccine, showing protection against H5N1 challenge. The study demonstrates proof-of-concept, highlighting the potential for a key component of a future universal flu vaccine.

Combining magnetic materials with superconductors in heterostructures is a promising pathway for realizing topological superconductivity. Here, Zahner et al show that the boundary formed between monolayer and bilayer manganese deposited on top of superconducting Tantalum can host spin polarized edge modes, the result of different topological superconducting phases of the monolayer and bilayer regions.

Across 17 forest plots (2.7 million trees, 5,400 species), competition dominated overall, but facilitation was relatively stronger near the equator and declined towards higher latitudes, partly linked to temperature, legumes, mycorrhizal associations and canopy nursing effect.

The Mouse Cancer Cell line Atlas (MCCA) provides major advances towards a mechanistic understanding of cancer genomes.

Researchers reveal that TNF alpha unmasks a metabolic impairment in the enteric malate-aspartate shuttle. This dysfunction acts as a key pathological bridge linking intestinal inflammation to the neurodegeneration seen in Parkinson’s disease.

Groundwater, enhanced through managed aquifer recharge, is crucial for alleviating water stress. This study demonstrates that isotopic tracers, including tritium from nuclear power plant effluents, can be used to map groundwater flow in Swiss alluvial systems, revealing insights into groundwater travel time distributions and informing sustainable groundwater management globally.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Ultrafast near-field microscopy unites femtosecond optical spectroscopy with nanometre spatial resolution to image non-equilibrium material dynamics beyond the diffraction limit. This Primer outlines theory, instrumentation, signal interpretation and representative applications, providing a practical foundation for generating and analysing ultrafast nano-movies of quantum materials.

Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.

A common technique to cool down molecular ions is through collisions with a buffer gas, but that is limited by the achievable temperature of the medium. Now, an experiment demonstrates the evaporative cooling of molecular ions below previously reached temperatures.

Here, the authors mapped signal flow over days from intracranial brain recordings in humans. Across vigilance stages, limbic structures sent twice as many signals as they received from the neocortex, challenging the long-standing hypothesis of flow reversal in sleep.

In this work, an exotic nuclear decay in one dimension is simulated using IonQ trapped-ion quantum computers. The coherent evolution of many decay channels is classically hard and quantum simulation of these processes may impact future searches for new physics.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

A universal approach to construct low-resistance oxide layer by multiple tunnelling paths is proposed for efficient and durable Si-based photocathode. This approach can speed up the pace of development of practical photoelectrochemical devices.

Saturable absorption, a technologically relevant property of graphene, is usually explained with Pauli blocking of optically driven carriers in the strong-excitation regime. Here, Winzeret al. reveal a new saturation regime at low excitations, resulting in a double-bended saturation behaviour.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Here, the authors reveal how twisting MoSe₂/WS₂ layers controls exciton behaviour. Combining theory and ultrafast spectroscopy, they show that lattice reconstruction creates distinct bright and long-lived excitons without hybridization effects.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

This combined experimental and theoretical study of a collinear antiferromagnet reveals a large magnetic exchange driven structural shift and non-coplanar domain wall junctions, which exhibit a topological orbital magnetization.

While the emergence of immune checkpoint inhibitors has improved outcomes in patients with small cell lung cancer (SCLC), tumour that develop means of immune evasion become resistant. Here, the authors report that ERBB2 signalling induces loss of MHC Class I expression and subsequently immune evasion in preclinical models of SCLC.

Addressing how the nitrogen-induced changes in plant diversity differ from those in soil organisms is critical. This global meta-analysis suggests that nitrogen enrichment has stronger negative effects on plant diversity but modest to negligible effects on soil bacterial and fungal diversity.

To enable a sensed RNA to activate diverse RNA effectors, the authors engineer a programmable dual-site ribozyme that, upon RNA trigger binding, self-cleaves to release an embedded RNA. It enables trigger-dependent release of diverse ncRNAs and controls CRISPR-Cas9 editing in zebrafish and human cells.

Sepsis causes endothelial dysfunction that drives vascular failure and organ injury. Here the authors show that neutralizing truncated procalcitonin reduced pro-inflammatory activation and leakage in the endothelium, resulting in preserved organ integrity, improved clinical outcomes and predicted survival in septic mice.

Here, the authors use a mouse model of multiple sclerosis to show that CD38⁺Foxp3⁺ T_reg cells persist in postinflammatory CNS tissues and are needed for maintaining immune homeostasis. These localized stress-tolerant T_reg cells have developed mechanisms to exploit the limited availability of IL-2 in this tissue.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Attosecond pulse generation needs improvements both in terms of tunability and photon flux for next level attosecond experiments. Here the authors show how to control the HHG emission and its spectral-temporal characteristics by driving the IAP generation with synthesized sub-cycle optical pulses.

N-Myristoylation by NMT1 is an essential modification in humans safeguarding transient membrane anchorage of proteins. Here, the authors use cryo-EM to visualize the foundation for the co-translational modification activity of NMT1 on the ribosome.

Mineral carbonation could enable gigatonne-scale CO₂ removal. Here, the authors use molecular simulations to map a full CO₂ mineralization pathway at a wetting surface, revealing key reactive sites and optimal pH conditions for efficient carbonation.

Coherently projecting a quantum state may allow it to be probed from a distance. This is now demonstrated for a Yu–Shiba–Rusinov state using a quantum corral.

The isotopic label tritium can be selectively added into aromatic organic compounds by a homogenous hydrogenolysis reaction using aryl thianthrenium salts, tritium gas and a molecular palladium catalyst.

Taveneau et al. leverage artificial-intelligence-driven protein design to create inhibitors that control RNA-targeting enzymes in cells, revealing a strategy to rapidly design off-switches for RNA-editing systems.

In a hybrid superconductor–ferromagnet device, the dynamic stray fields of current-driven vortices unidirectionally excite coherent short-wavelength magnons.

Concrete durability is crucial for infrastructure longevity. Here the authors use atomistic simulations to show how aluminum alters the bonding and surface energetics of cement hydrates, explaining its paradoxical dual role in durability.

The extreme hot and dry conditions of 2023 reduced soil respiration and enhanced net forest carbon sequestration in Canada, offsetting wildfire emissions, according to satellite-based and in situ observations of CO₂ fluxes.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Topologically trivial and Majorana bound states can show spectral weight near the ends of a chain of magnetic atoms on a superconductor. Here, the authors disentangle the two contributions by augmenting a spin chain with orbitally-compatible nonmagnetic atoms, where a persistent zero-energy spectral weight at the transition between the two parts is observed.

Graphene has so far demonstrated remarkable properties, making it increasingly interesting for ultrafast electronic applications. Here, the authors show that, when probed by a highly charged ion, freestanding graphene is able to provide dozens of electrons for ion neutralization within a few femtoseconds.

Small clusters of magnetic atoms can behave in very different ways to those same atoms in bulk. Arranging iron atoms one by one into complex but well-defined patterns on a copper surface enables the construction of nanoscale magnetic structures with tailored characteristics.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.