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Showing 1–12 of 12 results
Advanced filters: Author: Ronan Chaligné Clear advanced filters

  • Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomeninges.

    • Jan Remsik
    • Xinran Tong
    • Adrienne Boire
    ResearchOpen Access
    Nature
    Volume: 643, P: 1087-1096

  • Colorectal cancer metastasis involves dramatic plasticity and loss of PROX1-mediated repression of non-intestinal lineages.

    • Andrew Moorman
    • Elizabeth K. Benitez
    • Karuna Ganesh
    ResearchOpen Access
    Nature
    Volume: 637, P: 947-954

  • Sawyers and colleagues describe an in vivo platform used to explore the dynamics and key factors of neuroendocrine lineage transformation. They find that Ascl1 depletion blocks plasticity and leads to cancer that is sensitive to castration.

    • Rodrigo Romero
    • Tinyi Chu
    • Charles L. Sawyers
    ResearchOpen Access
    Nature Cancer
    Volume: 5, P: 1641-1659

  • Implementing high-throughput single-cell DNA sequencing for the study of solid tumours has been challenging. Here, the authors present an optimised approach for snap-frozen tissue single nuclei extraction and DNA sequencing, which can be applied to study pancreatic ductal adenocarcinoma evolution and heterogeneity.

    • Haochen Zhang
    • Elias-Ramzey Karnoub
    • Christine A. Iacobuzio-Donahue
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • The JAK2V617F mutation leads to epigenetic rewiring in a cell-intrinsic and cell-type-specific manner, influencing inflammation states and differentiation trajectories in patients with myeloproliferative neoplasms.

    • Franco Izzo
    • Robert M. Myers
    • Dan A. Landau
    Research
    Nature
    Volume: 629, P: 1149-1157

  • In a zebrafish model of human cutaneous and acral melanomas, CRKL amplification causes tumours to favour a fin location, indicating that tumour location is determined by both the driver oncogenes and the pre-existing positional identity gene program.

    • Joshua M. Weiss
    • Miranda V. Hunter
    • Richard M. White
    Research
    Nature
    Volume: 604, P: 354-361

  • The imminent release of tissue atlases combining multichannel microscopy with single-cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards to guide data deposition, curation and release. We describe a Minimum Information about Highly Multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and for other microscopy data to highly multiplexed tissue images and traditional histology.

    • Denis Schapiro
    • Clarence Yapp
    • Peter K. Sorger
    Comments & Opinion
    Nature Methods
    Volume: 19, P: 262-267