Nature Search

Inhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice

Cancer stem cells contribute to cancer evasion and relapse by suppressing the immune response. Here, the authors identify sterol O-acyltransferase 1 (SOAT1) as a cancer stem cell immune checkpoint and propose that SOAT1 inhibition results in oxysterol-mediated reprogramming of intratumoral regulatory T cells via a trans-cellular 20SOHC-GPR132, ultimately enhancing anti-tumor immunity in various preclinical mouse models.

Yahui Ding
Wanqi Fang
Steven X. Hou
ResearchOpen Access17 Mar 2026
Nature Communications

P: 1-19
Visualization of photocuring and 4D printing with real-time phosphorescence

It is favourable to be able to monitor the curing process during 3D printing, but this is challenging to achieve. Here, the authors report the use of room temperature phosphorescence to monitor the curing process, by combination of phosphors with commercial printing resin.

Fan Gu
Mengxing Ji
Xiang Ma
ResearchOpen Access05 May 2025
Nature Communications

Volume: 16, P: 1-10
Fractal dimension of steel slag foamed concrete and its connection with compressive strength

Qianqian Chen
Feiyang Shao
Ming Zhang
ResearchOpen Access17 Nov 2025
Scientific Reports

Volume: 15, P: 1-14
Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression

Xiaojuan Yao
Ruiying Chen
Xiao Xiao
Research15 Dec 2025
Molecular Psychiatry

P: 1-19
Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin

Fengze Sun
Yuanyuan Liu
Jianchuan Xia
ResearchOpen Access18 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-9
Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies

Yuxin Zhang
Xing Wang
Yanjiang Qiao
ResearchOpen Access22 Sept 2017
Scientific Reports

Volume: 7, P: 1-12

Quick links

Search

Filter By:

Inhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice

Visualization of photocuring and 4D printing with real-time phosphorescence

Fractal dimension of steel slag foamed concrete and its connection with compressive strength

Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression

Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin

Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies

Search

Quick links