The testis-determining factor SRY, which is encoded on the Y chromosome, forms a complex with an orphan nuclear receptor SF1, and together they bind to an enhancer regulating Sox 9. Sox9 controls the expression of genes involved in male development. Earlier work had suggested that Sox9 is a target of SRY. However, this study identifies a direct regulatory interaction at the level of transcriptional regulation, and identifies the enhancer element responsible.
- Ryohei Sekido
- Robin Lovell-Badge
