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Organophosphoryl compounds are important motifs, however regioselective phosphorylation of alkenes remains challenging. Here, the authors report a visible light driven triple catalytic strategy enabling radical Markovnikov hydrophosphorylation of unactivated alkenes via sequential reaction of (bis)homoallylic alcohols, Ph₂PCl, and water.

Preeclampsia (PE) is a serious pregnancy complication characterized by hypertension and organ dysfunction. Here, the authors show that lipid nanoparticles co-loaded with polydopamine and NUAK1 can reduce oxidative stress and inflammation, improving placental function and fetal growth in a preeclampsia mouse model.

Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non-canonical nuclear metabolic roles in cancer.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Atherosclerotic carotid stenosis leads to stroke, but how perivascular adipose tissue (PVAT) drives plaque instability is poorly understood. Here the authors show that PVAT harbours distinct ADSC subsets, with CD55⁺ADSCs promoting plaque angiogenesis via FGF2 and CXCL14⁺ADSCs enhancing inflammation, driving plaque destabilization.

A randomised trial in metformin-treated type 2 diabetes found once-weekly efsubaglutide improved HbA1c and fasting glucose, reduced weight, and enhanced meal-stimulated insulin secretion with mainly mild GI side effects.

Immune checkpoint inhibitors combined with chemotherapy have demonstrated significant benefits in treating triple-negative breast cancer (TNBC). In this study, the authors present results from a randomized phase II trial evaluating the platinum-based and DNA-damaging agent carboplatin in combination with nivolumab in patients with metastatic TNBC.

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

Oxidative stress and dsRNA are key drivers of skin inflammation, while therapies targeting oxidative stress are common, dsRNA targeting is not. Here, the authors report on a cerium-doped polyoxometalate with anti-oxidative and dsRNA binding properties showing potential for a transdermal strategy to reduce skin inflammation.

This study reconstructs Earth’s temperature over the past 539 million years by integrating rock chemistry and climate models, showing that global temperatures remained within ~10–30 °C, challenging ideas of anomalously high early Paleozoic climates.

Maternal obesity is a risk factor for developing chronic kidney disease in the offspring later in life. Here the authors study male offspring in a mouse model of maternal obesity and identify dysregulated metabolism due to disrupted crosstalk between proximal tubules and macrophages as an important mechanism.

Paediatric acute respiratory distress syndrome (ARDS) is a potentially life-threatening condition in children, understanding the immuno-pathology is of importance. Here the authors employ a high-dimensionality approach to identify dysregulated immune pathways underpinning the condition, and find important differences compared to ARDS in adults.

Short-read sequencing-based approaches are limited to gene-level expression and cannot identify full-length transcript isoforms. Here, the authors apply single-cell long-read RNA sequencing to glioblastoma and identify tumor-specific isoforms and peptides deriving from them as neoantigens.

Hypoxia-driven dysregulated lactate metabolism is a feature of intervertebral disc degeneration (IDD), but biological metabzymes and most biomimetic counterparts are ineffective under hypoxic conditions and often yield harmful metabolites. Here, the authors report a biogenic Fe-N-C artificial metabzyme for IDD metabolic therapy that reprograms lactate metabolism and corrects metabolic dysfunction.

Microsatellite-stable/proficient mismatch repair colorectal cancers are resistant to immune checkpoint blockade immunotherapy due to their immune suppressive tumour microenvironment. Here the authors show in mouse models that the transcription factor Arid3b contributes to the suppression of CD8 + T cell infiltration and activity in these tumours via suppressing Runx3, a known regulator of tissue resident memory phenotype in CD8 + T cells.

The physiologic roles of the neurotransmission from PVHCRH neurons remain untested. Here, authors show differential roles of glutamate and CRH release from PVHCRH neurons in diet-induced obesity but a permissive role for their release in the HPA axis.

Spatial transcriptomics platforms span multicellular to subcellular resolutions but lack methods to reconstruct single-cell transcriptomes across them. Here, the authors introduce STARS, a unified deep learning framework that integrates histology and transcriptomics to infer single-cell gene expression across resolutions.

Climate change is altering the timing—not just the volume—of meltwater from the Asian Water Tower. Although meltwater has historically buffered dry‑season urban water scarcity, future increases are concentrated in the monsoon season, weakening its effectiveness just as urban water demand rises.

Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

Nanofluidic technologies require precise control of ion and molecular transport at the nanoscale, yet existing fabrication methods face limitations in cost, scalability, and programmability. Authors demonstrate the use of self-grown fungal mycelium to create adaptable nanofluidic devices that exhibit significant ion transport capabilities.

This study utilizing data from the UK biobank suggests that plasma proteomics profiles significantly improve prediction of the incidence of 17 diseases, for example some types of cancer and cardiometabolic diseases, over standard clinical predictors and metabolomics profiles.

The potency of a class of RAF kinase inhibitors was found to depend on cancer cell signaling activity. This insight informed reengineering of a clinically approved MEK inhibitor to block this cancer-driving pathway more effectively in combination.

Ketogenic diet (KD) generates β-hydroxybutyrate metabolites and has been shown to have context-dependent immunomodulatory effects. However, the effects of KD on inflammatory bowel disease (IBD) are controversial. Here, the authors investigate the pathogenic effects of KD in a preclinical model of DSS-induced colitis and identify a β-HB-Thomasclavelia spiroformis-γδ17 T cell axis that exacerbates inflammation and mucosal damage.

Molecular precursors containing V, Bi and Zn are thermally transformed into oxide materials. Detailed studies reveal and characterise the formation of amorphous intermediates, a new kinetic polymorph of BiVO₄, and incorporation of Zn dopants.

H5N1 avian influenza viruses have pandemic potential, yet antibody responses to their neuraminidase aren’t well studied. Here, the authors demonstrate that childhood exposure to H1N1 viruses enhances cross-reactive antibody levels against H5N1 neuraminidase, highlighting the potential impact of immune priming on future influenza virus risks.

Porous frameworks assembled from biologically derived building blocks have diverse potential applications. Here, the authors report the development of crystalline mesoporous frameworks fabricated from the self-assembly of amphiphilic collagen-mimetic peptides.

The authors establish high-resolution spatiotemporal landscapes of AKI. They reveal that surviving epithelial cells are the primary drivers of kidney regeneration through proliferation, offering insights into the mechanism of kidney repair after AKI

Paediatric heart conditions are rare and complex, complicating treatment planning. Here, the authors show that machine learning models can predict hospital stays and retrieve comparable cases, providing clinically useful insights for decision-support.

RUNX2⁺ keloid fibroblasts highly expressing ADRB1 produce bone matrix proteins in response to neurotransmitters from catecholaminergic nerves. Blocking this neuro-stromal interaction prevents fibro-osseous reprogramming and keloid progression.

CNS injury disrupts neural circuits, with poor regeneration due to HDAC retention and hostile environments. Here, the authors show a nanosystem with LMK-235 that forms electroactive scaffolds and promotes regeneration and enhances synaptic reconnection

This work shows humidity-controlled hygroscopic deliquescence as an entropy increasing route for spontaneous lithium extraction from complex mining slags, enabling rapid, selective recovery in ambient conditions with scalable, low-energy potential.

Previous work suggests that heterogeneous static networks hinder collective cooperation fixation. Here, the authors show that heterogeneous temporal networks outperform homogeneous ones by accelerating cooperative spread—an effect washed out in static cases.

This study shows that the UMOD p.H36Y mutation promotes kidney inflammation by enabling mutant tubular cells to trigger macrophage pyroptosis through the App–Cd74 pathway.

The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

Valine metabolism disruption is linked to heart disease, but the mechanisms are unclear. Here, the authors show that ACAD8 deficiency drives isobutyryl-CoA accumulation and histone isobutyrylation, increasing chromatin accessibility and gene expression to promote cardiac hypertrophy, while ACAD8 overexpression reverses these effects.

Researchers demonstrate an optical “vortex reconstructor” that restores orbital angular momentum light beams degraded by obstruction. The method recovers the helical wavefront even when more than half of the beam is blocked, enabling more robust vortex-based optical technologies.

Caspase-8 plays a key role in initiating pyroptosis, but its contribution to myocardial infarction has remained unclear. Here, the authors show that ischemia-induced degradation of Dnmt3a leads to demethylation and upregulation of Caspase-8, amplifying Gsdmd cleavage and driving cardiomyocyte death.

Here authors demonstrate that ion transport in acceptor-doped melilite solid electrolytes is driven by interstitial cation migration rather than oxygen vacancies, revising the defect chemistry of this important family of energy materials.

Applying the right to be forgotten to electronic health records that have been used to train artificial intelligence models could compromise model accuracy and fairness. Here, the authors develop a machine unlearning model that aims to remove data whilst preserving algorithmic fairness across subgroups.

Osteoporotic fractures often heal poorly due to high oxidative stress. Here, the authors develop an intelligent responsive hydrogel coating for magnesium implants that decelerates implant degradation, alleviates oxidative stress, and promotes bone regeneration.

How low-energy particles are pre-accelerated and injected into the diffusive shock acceleration process has long been a mystery. Here, the authors show the shock discontinuity interaction induces intense electron acceleration and may be a solution.

Autophagic activity has a protective role in Alzheimer’s disease in mice. Here the authors investigate the role of autophagy-initiating protein ULK1 and report that its overexpression stimulates autophagic flux, reduces amyloid and tau pathology and delays cognitive decline.

CRISPRa screening in primary human cells has remained a formidable technical challenge. Here, the authors developed dCas12f1-SAM and successfully implemented a gain-of-function screen in primary human T cells, identifying key regulators of T cell activation.

This research reveals that platelet infiltration initiated by the platelet HuR-PSPF regulatory process coordinates systemic aging. Targeting platelet HuR may be a promising strategy for anti-aging interventions

Inner ear diseases are difficult to treat due to anatomical constraints. Here, the authors present a dual-segment continuum robot integrating navigation, endoscopy, and a force-sensing microneedle for atraumatic transcanal access to the round window membrane.

This study establishes the link between epithelial zinc transporter SLC39A1 and acute lung injury. The authors uncover a protective mechanism in lung epithelium mediated by the SLC39A1-zinc-autophagy axis and highlight SLC39A1 as a potential therapeutic target.

This work develops a 3D-printed aluminium alloy with an Al₃Er nanoscale skeleton that deforms rather than breaks, achieving 700 MPa strength and 7% elongation, the mechanisms of which enable stronger lightweight structural metals.

An electrothermal fluorination methodology has been developed to transform granular activated carbon-sorbed aqueous film-forming foam waste into graphene and a fluorinating reagent, subsequently enabling lithium recovery from brine sources.