Search

By unifying data from engineered β-barrel nanopores and supported by modelling, it is demonstrated that the lumen charge in a β-barrel nanopore governs rectification and voltage-driven gating, with applications in computing using nanofluidic synapses.

The perceived toxicity of organometallic reagents has limited their use in living systems. Now it has been shown that balancing flexible chelation with biocompatible ligands without precluding chemical reactivity enables organonickel-mediated S-arylation inside cells. This reaction enables deep chemical surveys of reactive proteins and covalent tracking of intracellular viral and bacterial pathogens.

The multifunctional soft sensors attached to the glove are capable of simultaneously sensing six stimuli, including pressure, bending strain, temperature, proximity, UV light, and humidity, with high accuracy and without interference among the respective built-in components. The sensor is fabricated via supersonic spraying using silver nanowires, carbon nanotubes, zinc oxide, and conducting polymer poly(3,4-ethylenedioxythiophene) polystyrene sulfonate.

The introduction of fluorine into organic molecules often requires prefunctionalised molecules or protection of reactive functional groups. Here, the authors report a biocatalytic method for the trifluoromethylation of unprotected phenols under mild conditions.

S protein interacts with and activates PBP1a during cell division, as part of a larger GpsB-associated multiprotein complex that coordinates peptidoglycan remodelling in Streptococcus pneumoniae.

The successful coating of an ionic liquid with silver, where the surface is smooth and the silver coating is stable on a timescale of months, is reported. The ionic liquid does not evaporate in a vacuum and remains liquid down to a temperature of 175 K. The synthesis of liquids with melting points <130 K should be possible.

Formamidinium lead iodide perovskite films exhibit picosecond-scale quantum transients (~2 ps), with their nanoscale superlattices defining energy levels that yield narrow emission lines and reveal the structure–emission relationship.

Xenotransplantation of a genetically edited pig kidney with a thymic autograft into a brain-dead human for 61 days with immunosuppression resulted in stable kidney function without proteinuria, and xenograft rejection was treated and reversed by the end of the study.

Yeast cells are engineered to prepare multifunctional synthetic biofragments as nanoprobes, which allow multivalent interactions and optimal molecular orientation on material surfaces for the detection of emerging biomarkers in a range of sensor platforms.

Constraining projections using best-performing climate models, uncertainties in future temperature variability can be narrowed, yet remain large over poorly modelled regions, highlighting the need for multiple model ensembles to assess future risks.

Anaerobic methanotrophic archaea play crucial roles in the methane cycle. Here, Zhang et al. provide experimental evidence supporting that multi-heme cytochromes mediate extracellular electron transfer for the reduction of metals and electrodes in these microorganisms.

Powdery mildew is a devasting disease for both common wheat and durum wheat. Here, the authors report a pair of genetically linked nucleotide-binding leucine-rich repeat (NLR)-encoding genes confer powdery mildew resistance and show its potential in wheat disease-resistant breeding.

Combining time-resolved IR spectroscopy, activation energy analyses, and computations, authors provide mechanistic insight into genetically altered reaction kinetics of light-driven oxygen evolution in photosystem II.

Fatty liver disease exacerbates atherosclerosis, but the underlying mechanisms remain unclear. Here, the authors show that D-dopachrome tautomerase (D-DT/MIF-2) acts as an atypical chemokine, promoting both atherosclerosis and hepatic lipid accumulation.

In this work, authors present an AI framework to detect pediatric tuberculosis by using both frontal and lateral chest X-rays, showing robust performance across several age groups and settings.

Sulfur isotope excursions in skeletal collagen samples from Eurasia suggest rapidly changing biogeochemical processes across the region from about 30,000 to 15,000 years ago, potentially related to changing permafrost conditions.

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

Solar photovoltaics is entering a multi-terawatt era, driven by decades of cost, performance and reliability gains. In this Perspective Alberi et al. discuss the role of historical and future learning, highlighting the increasing importance of sustainability considerations.

Protein corona formation on nanoparticles and the resultant effects on cellular interactions is well documented, where less is known about the fate of the corona in the cell. Here, the authors track the protein corona and nanoparticles in cells and describe the separation and different processing within different cellular compartments.

Accessing multi-angle views of organoids is important for biology and oncology. The authors propose ultrasound-induced reorientation for multi-angle optical coherence tomography, using a 3D-printed acoustic trap to levitate and rotate samples with a model-based algorithm for reconstruction.

Silver nanoparticles with thin palladium shells are active and selective catalysts for the production of hydrogen from formic acid at room temperature.

A small number of patients who received growth hormone preparations contaminated with seeds of the amyloid-beta protein developed Alzheimer’s disease many years after treatment.

Scientists find that spongin, a key biomaterial in sponges, contains the same collagens as mammals and that these biocomposites contain brominated crosslinks. Now, the question: “Maybe we are all sponge to some degree?” is no longer so absurd.

Microglia and border-associated macrophages play a role in regulating cerebral blood flow (CBF), but the underlying mechanisms are unclear. Here, the authors show a role for microglial CD39 in the regulation of basal CBF and neurovascular coupling.

Eribulin is an anticancer drug and the most structurally complex non-peptidic drug made by chemical synthesis. Here, the authors report a streamlined synthesis of eribulin that creates new opportunities for drug discovery and development.

Together with a companion paper, molecular details of immune responses in a pig-to-human xenotransplantation are identified through dense longitudinal multi-omics profiling of the xenograft and the host recipient, across the 61-day procedure.

An approach using multiple stable isotopes reveals that early tetrapods of the Devonian period were euryhaline animals that inhabited aquatic environments of highly variable salinity.

Low bandgap tin–lead perovskites are crucial to making efficient all-perovskite tandem solar cells but have so far shown poor stability. By removing the hole transport layer and improving film morphology, Prasanna et al. demonstrate a low-gap perovskite solar cell that is stable for 1,000 h under heat, light and atmospheric conditions.

Although high-entropy metal chalcogenides are attractive candidates for energy conversion and catalysis, their stability under high pressure is not well understood. Here, a combination of electron microscopy, elemental analysis and electron diffraction with machine learning shows that compression and pressure-annealing of the (MnFeCuAgZnCd)S wurzite leads to exsolution of a chemically distinct jalpaite.