Nature Search

Dynamical simulations of many-body quantum chaos on a quantum computer

Studying many-body quantum chaos on current quantum hardware is hindered by noise and limited scalability. Now it is shown that a superconducting processor, combined with error mitigation, can accurately simulate dual-unitary circuit dynamics.

Laurin E. Fischer
Matea Leahy
Sergey N. Filippov
Research20 Jan 2026
Nature Physics

P: 1-6
Inverted duplications are recurrent rearrangements always associated with a distal deletion: description of a new case involving 2q

Maria Clara Bonaglia
Roberto Giorda
Orsetta Zuffardi
Research31 Jul 2000
European Journal of Human Genetics

Volume: 8, P: 597-603
Opposite deletions/duplications of the X chromosome: two novel reciprocal rearrangements

Sabrina Giglio
Barbara Pirola
Orsetta Zuffardi
Research22 Feb 2000
European Journal of Human Genetics

Volume: 8, P: 63-70
Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching

Sandro Banfi
Giuseppe Borsani
Andrea Ballabio
Research01 Jun 1996
Nature Genetics

Volume: 13, P: 167-174
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Ultra-high-energy gamma-ray bubble around microquasar V4641 Sgr

Ultra-high-energy gamma-ray emission from the microquasar V4641 Sagittarii is reported, suggesting that large-scale jets from microquasars could be more common than previously thought and also could be a notable source of galactic cosmic rays.

R. Alfaro
C. Alvarez
H. Zhou
Research16 Oct 2024
Nature

Volume: 634, P: 557-560
Identification of constrained sequence elements across 239 primate genomes

Whole-genome alignment of 239 primate species reveals noncoding regulatory elements that are under selective constraint in primates but not in other placental mammals, that are enriched for variants that affect human gene expression and complex traits in diseases.

Lukas F. K. Kuderna
Jacob C. Ulirsch
Kyle Kai-How Farh
ResearchOpen Access29 Nov 2023
Nature

Volume: 625, P: 735-742
Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma

Understanding the dynamics of the gut microbiota over the course of cancer treatment regimens and their associated adverse events can help identify microbial features that associate with response to immune checkpoint blockade.

Johannes R. Björk
Laura A. Bolte
Rinse K. Weersma
ResearchOpen Access16 Feb 2024
Nature Medicine

Volume: 30, P: 785-796
Angiogenic and immune predictors of neoadjuvant axitinib response in renal cell carcinoma with venous tumour thrombus

Venous tumour thrombus can occur within renal cell carcinoma, and can require complex additional surgery and treatment. Here, the authors analyse multiparametric data from patients treated with axitinib and develop a machine learning model to predict neoadjuvant treatment response.

Rebecca Wray
Hania Paverd
Robert J. Jones
ResearchOpen Access28 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Primary and metastatic tumours have different metabolic phenotypes due to changes in nutrient availability. Here the authors perform multi-omic analyses of primary and metastatic renal cancer cells grown in a physiological medium and show that the reprogramming of the branched-chain amino acid catabolism and urea cycle through re-expression of ASS1 allows metabolic flexibility during renal cancer progression.

Marco Sciacovelli
Aurelien Dugourd
Christian Frezza
ResearchOpen Access20 Dec 2022
Nature Communications

Volume: 13, P: 1-20
Prevention of obesity in toddlers (PROBIT): a randomised clinical trial of responsive feeding promotion from birth to 24 months

Anita Morandi
Mara Tommasi
Claudio Maffeis
Research03 Jul 2019
International Journal of Obesity

Volume: 43, P: 1961-1966
Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth

Glioblastoma cancers contain brain tumour-initiating cells and targeting these specific cells is an attractive opportunity for therapy. In this study, the authors show that FOXG1 and Groucho/TLE transcription factors are important for glioblastoma growth and might be useful therapeutic targets.

Federica Verginelli
Alessandro Perin
Stefano Stifani
Research20 Dec 2013
Nature Communications

Volume: 4, P: 1-16
Development of bivalent RBD adapted COVID-19 vaccines for broad sarbecovirus immunity

Laura A. Bruno
Celeste Pueblas Castro
Juliana Cassataro
ResearchOpen Access29 May 2025
npj Vaccines

Volume: 10, P: 1-10
Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer

Oral cancer has region-specific histopathological and molecular characteristics, complicating its classification by the standard tumor-node-metastasis system. Here, the authors combine discovery and targeted proteomics with IHC to identify region-specific and saliva biomarkers for oral cancer prognosis.

Carolina Moretto Carnielli
Carolina Carneiro Soares Macedo
Adriana Franco Paes Leme
ResearchOpen Access05 Sept 2018
Nature Communications

Volume: 9, P: 1-17
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

A study of SARS-CoV-2 variants examining their transmission, infectivity, and potential resistance to therapies provides insights into the biology of the Delta variant and its role in the global pandemic.

Petra Mlcochova
Steven A. Kemp
Ravindra K. Gupta
ResearchOpen Access06 Sept 2021
Nature

Volume: 599, P: 114-119
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.

Michael R. Bowl
Michelle M. Simon
Steve D. M. Brown
ResearchOpen Access12 Oct 2017
Nature Communications

Volume: 8, P: 1-11
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Individuals over eighty years of age are less likely to mount a good immune response against SARS-CoV-2 (measured by neutralization titres) after the first dose of the BNT162b2 mRNA vaccine, but achieve good neutralization after the second dose.

Dami A. Collier
Isabella A. T. M. Ferreira
Ravindra K. Gupta
ResearchOpen Access30 Jun 2021
Nature

Volume: 596, P: 417-422
Single-cell multi-omics analysis of the immune response in COVID-19

Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoietic progenitor cell alterations that are differentially associated with disease severity.

Emily Stephenson
Gary Reynolds
Muzlifah Haniffa
ResearchOpen Access20 Apr 2021
Nature Medicine

Volume: 27, P: 904-916
Identification of genetic elements in metabolism by high-throughput mouse phenotyping

The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulatory gene networks and metabolic traits in human GWAS.

Jan Rozman
Birgit Rathkolb
Martin Hrabe de Angelis
ResearchOpen Access18 Jan 2018
Nature Communications

Volume: 9, P: 1-16
The coexistence of a BRCA2 germline and a DICER1 somatic variant in two first-degree cousins suggests their potential synergic effect

Giada Del Baldo
Angela Mastronuzzi
Isabella Giovannoni
ResearchOpen Access13 Sept 2024
Scientific Reports

Volume: 14, P: 1-9
Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Empirically based models of disease progression in familial frontotemporal dementia reveal the relative ordering of clinical, neuroimaging, and fluid biomarker changes and facilitate novel clinical trial designs

Adam M. Staffaroni
Melanie Quintana
Sónia Afonso
Research22 Sept 2022
Nature Medicine

Volume: 28, P: 2194-2206
Phenotypic spectrum and prevalence of INPP5E mutations in Joubert Syndrome and related disorders

Lorena Travaglini
Francesco Brancati
Enza Maria Valente
Research06 Feb 2013
European Journal of Human Genetics

Volume: 21, P: 1074-1078
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Evolutionarily conserved gene modules mediate neurodegenerative dementia in a variety of mouse models and in postmortem brain tissue from patients.

Vivek Swarup
Flora I. Hinz
Daniel H. Geschwind
Research03 Dec 2018
Nature Medicine

Volume: 25, P: 152-164
Cost-effectiveness of one-off upper abdominal CT screening as an add-on to lung cancer screening in England

Chloe Thomas
Laura Heathcote
Tom Wallace
ResearchOpen Access14 May 2025
British Journal of Cancer

Volume: 133, P: 239-247
Evidence of DNA methylation heterogeneity and epipolymorphism in kidney cancer tissue samples

Sabrina H. Rossi
Victoria Dombrowe
Charlie E. Massie
ResearchOpen Access17 Jan 2025
Oncogene

Volume: 44, P: 1024-1036
Versatile enhancement of the killing potential of anti-cancer agents achieved by peptide mimetics of the PCNA interface towards specialized DNA polymerases

Yiovana Verónica Okraine
María Belén de la Vega
Vanesa Gottifredi
ResearchOpen Access08 Jul 2025
Cell Death & Disease

Volume: 16, P: 1-17
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells

Giulio Bontempi
Michela Terri
Raffaele Strippoli
ResearchOpen Access17 Nov 2022
Cell Death & Disease

Volume: 13, P: 1-14
HMGA1 and HMGA2 protein expression in mouse spermatogenesis

Paolo Chieffi
Sabrina Battista
Alfredo Fusco
Research21 May 2002
Oncogene

Volume: 21, P: 3644-3650
Neurofibromin C terminus-specific antibody (clone NFC) is a valuable tool for the identification of NF1-inactivated GISTs

Sabrina Rossi
Daniela Gasparotto
Angelo Paolo Dei Tos
Research01 Sept 2017
Modern Pathology

Volume: 31, P: 160-168
Black-legged kittiwakes as messengers of Atlantification in the Arctic

Mikko Vihtakari
Jorg Welcker
Geir Wing Gabrielsen
ResearchOpen Access19 Jan 2018
Scientific Reports

Volume: 8, P: 1-11
Environmental factors driving the abundance of Philaenus spumarius in mesomediterranean habitats of Corsica (France)

Marguerite Chartois
Xavier Mesmin
Astrid Cruaud
ResearchOpen Access02 Feb 2023
Scientific Reports

Volume: 13, P: 1-11
Current evidence on screening for renal cancer

Renal cell carcinoma (RCC) incidence is increasing worldwide. Here, the authors consider the potential benefits and harms of screening for RCC and discuss whether enough evidence is available to begin a clinical trial of RCC screening.

Juliet Usher-Smith
Rebecca K. Simmons
Grant D. Stewart
Reviews28 Aug 2020
Nature Reviews Urology

Volume: 17, P: 637-642
Expanding the mutational spectrum of ReNU syndrome: insights into 5’ Stem-loop variants

Alessandro Bruselles
Cecilia Mancini
Marco Tartaglia
Research26 Feb 2025
European Journal of Human Genetics

Volume: 33, P: 432-440
IBM Q Experience as a versatile experimental testbed for simulating open quantum systems

Guillermo García-Pérez
Matteo A. C. Rossi
Sabrina Maniscalco
ResearchOpen Access07 Jan 2020
npj Quantum Information

Volume: 6, P: 1-10
Utility of the immunohistochemical detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody

Sabrina Rossi
Enrico Orvieto
Angelo P Dei Tos
Research05 Mar 2004
Modern Pathology

Volume: 17, P: 547-552
Evaluating cell culture reliability in pediatric brain tumor primary cells through DNA methylation profiling

Lucia Pedace
Simone Pizzi
Evelina Miele
ResearchOpen Access18 Apr 2024
npj Precision Oncology

Volume: 8, P: 1-13
Correction: Prevention of obesity in toddlers (PROBIT): a randomised clinical trial of responsive feeding promotion from birth to 24 months

Anita Morandi
Mara Tommasi
Claudio Maffeis
Amendments and Corrections12 Aug 2020
International Journal of Obesity

Volume: 44, P: 2177
Efficacy of S-PRG filler containing varnishes on enamel demineralization prevention

Manuela da Silva Spinola
Sabrina Elise Moecke
Carlos Rocha Gomes Torres
ResearchOpen Access04 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
GD2: hopes and challenges for the treatment of pediatric patients with tumors of the central nervous system

Alba Clara Fernández-Rilo
Emmanuel de Billy
Maria Vinci
ReviewsOpen Access21 Aug 2025
npj Precision Oncology

Volume: 9, P: 1-15
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma

Simona Daniele
Sabrina Taliani
Claudia Martini
ResearchOpen Access23 Apr 2014
Scientific Reports

Volume: 4, P: 1-13
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Identification of genes required for eye development by high-throughput screening of mouse knockouts

Bret Moore et al. from the International Mouse Phenotyping Consortium report the identification of 347 mouse genes that influence ocular phenotypes when knocked out. 75% of the identified genes have not previously been associated with any ocular pathology.

Bret A. Moore
Brian C. Leonard
Ala Moshiri
ResearchOpen Access21 Dec 2018
Communications Biology

Volume: 1, P: 1-12
A Phase II study of neoadjuvant axitinib for reducing the extent of venous tumour thrombus in clear cell renal cell cancer with venous invasion (NAXIVA)

Grant D. Stewart
Sarah J. Welsh
Robert J. Jones
ResearchOpen Access23 Jun 2022
British Journal of Cancer

Volume: 127, P: 1051-1060
Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

Yixin Gao
Ting Wang
Ping Zeng
ResearchOpen Access22 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Validation of a survival-risk score (SRS) in relapsed/refractory CLL patients treated with idelalisib–rituximab

Massimo Gentile
Enrica Antonia Martino
Fortunato Morabito
CorrespondenceOpen Access16 Sept 2020
Blood Cancer Journal

Volume: 10, P: 1-3
Legal issues in Neonatologist Performed Echocardiography. The Italian experience

Marilena Savoia
Salvatore Porzio
Federico Schena
Editorial14 Dec 2019
Pediatric Research

Volume: 87, P: 1140-1142
Chronic myeloid leukemia management at the time of the COVID-19 pandemic in Italy. A campus CML survey

Massimo Breccia
Elisabetta Abruzzese
Levato Luciano
Correspondence18 Jun 2020
Leukemia

Volume: 34, P: 2260-2261

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