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Methods for the enantioconvergent tertiary C–H functionalization are scarce, but desired for the construction of valuable compounds. Now, a highly enantioconvergent tertiary β-C(sp³)–H amination of racemic ketones with copper/chiral phosphoric acid dual catalysis is reported.

The role of TGFβ in cancer is paradoxical and context-dependent. Here, the authors discover that a preserved, DLD-mediated metabolic suppression by TGFβ undermines anti-TGFβ therapy, promoting gastric cancer growth.

Here, a draft sequence of the giant panda genome is assembled using next-generation sequencing technology alone. Genome analysis reveals a low divergence rate in comparison with dog and human genomes and insights into panda-specific traits; for example, the giant panda's bamboo diet may be more dependent on its gut microbiome than its own genetic composition.

This study presents azo-Q2a, a quinidine-derived photo-switchable molecule that enables optical control of Na_V1.5. It exhibits selectivity, and its binding mode is revealed by cryo-EM, offering a potential strategy for managing heart arrhythmia.

Cheng et al. developed an autophagy-based targeted protein degradation platform by conjugating polyethylenimine to antibodies, designated as autophagy-inducing antibodies, which can degrade proteins in vivo and enable the degradation of multiple proteins at the same time.

Anode-free Li metal batteries suffer from irreversible Li plating/stripping and interfacial side reactions. Here, authors propose a dual-gradient metal layer on Cu current collector to promote uniform Li deposition and the in situ formation of a stable solid electrolyte interphase.

The authors mapped the continental-scale fraction of age-dependent leaf area index and revealed a widespread increase in the fraction of photosynthetically efficient young leaves across the majority of Amazon rainforests over the past decades.

Extracellular vesicles encapsulating mRNA encoding for extracellular-matrix collagen and delivered intradermally via microneedles led to the replacement of collagen in the dermis of mice with photoaged skin.

Bacterial populations, programmed to self-assemble by adhesion of nanobody–antigen pairs, can be processed into living materials (LAMBA) that are scalable, self-healing and programmable through functionalization with diverse proteins.

Zhang et al. show that YAP binds to TDP-43 to promote TDP-43 multimerization and phase separation. YAP and TDP-43 may co-localize in multiple cell types in oxidative stress and in brain samples from individuals with amyotrophic lateral sclerosis.

State-of-the-art electrolytes limit the cycle life of halide-ion batteries. Here, the authors report a fluorinated low-polar gel polymer electrolyte capable of improving the stability of the electrolyte and electrode interphases to boost battery performance.

Tunability of ferroelectric domain structure is significant in ferroelectric materials. Here, the authors present in-plane ferroelectricity in 2D Bi₂TeO₅ in which the ferroelectric domain size and shape can be continuously tuned by the Bi/Te ratio.

This study describes a targeted artificial evolution strategy to create a continuum of compact phenotypes in cucurbit crops for higher yield and labour efficiency, based on screening natural populations and artificially generating novel variants.

All-in-one computing, which merges sensing, linear computing, and nonlinear activation, is a critical goal for next-generation AI hardware. Here, Zhang et al. introduce a high-speed, reconfigurable split-floating-gate memory, enabling multi-function integration within a unified platform and hardware native neuromorphic processing.

The cellular makeup of the primate cochlea, crucial for hearing, remains poorly understood. Here, authors show a detailed map of primate cochlear cells, revealing both conserved and species-specific features.

Achieving low charge overpotential in Li-O₂ batteries is critical yet highly challenging. Here, the authors report an orbital reconstruction strategy to enhance the oxygen evolution reaction kinetics by employing PdCo nanosheets, improving charge kinetics and energy conversion efficiency.

Multivalent interactions are crucial in transcriptional regulation. Here, by integrating specific multivalent molecules into dCas9-based activators, the authors provide valuable strategies to refine CRISPRa applications and achieve highly efficient gene transcription.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Extracting high-purity salt from saline water through conventional processes is complex and environmentally unsustainable. A diffusion-driven selective crystallization strategy that uses a precisely designed floating porous membrane to suppress non-ion-selective transfer enables simple and precise ion separation and high-purity salt production from mixed source solutions such as Na⁺/K⁺, Ba²⁺/K⁺ and Mg²⁺/Li⁺.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Recent studies have reported the growth of 2D non-centrosymmetric single crystals on substrates with surface steps, but the mechanisms are still unclear. Here, the authors demonstrate a method to grow unidirectionally aligned transition metal dichalcogenide grains on various types of substrates, showing the importance of the simultaneous formation of grain nuclei and substrate steps.

Li et al. present PRET, a few-shot system for pan-cancer detection not requiring model fine-tuning, validated it in multicenter datasets and found that it outperformed existing approaches across tasks and pathologists in lymph node metastasis detection.

Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.

Reconfigurable chip-to-free-space interfaces based on thin-film lithium niobate microrings generate on-demand nonlinear structured light, including tunable optical vortices, optical skyrmions and spatiotemporal vortex pulses.

An, Tan and colleagues reveal an unusual DNA phosphorothioation Tdp system, where TdpC adenylates DNA backbone for sulfur incorporation and TdpAB provides anti-phage immunity. The sensitivity of TdpAB to hydrophobicity of sulfur enables self–non-self discrimination.

Single-atom catalysts promise efficient reactions, but readily aggregate at high temperatures, limiting durability. Confining single metal atoms in liquid metal stabilizes them, enabling long-lasting ethane dehydrogenation at high temperature.

The authors reported an interfacial composite design that accommodates high oxide fraction and large stretchability, providing implications for developing stretchable composites with enhanced optical, electrical, thermal, and magnetic properties.

Divalent cation–exchanged zeolites enable complete ambient NO₂ removal with zero NO emission, overcoming a long-standing challenge in air purification and establishing a scalable pathway for zero-emission NO_x filtration.

A donor–π–acceptor carbon nitride photocatalyst with enhanced charge separation enables efficient hydrogen production from natural seawater under ambient pressure and sunlight, advancing scalable green hydrogen generation.

Developing earth-abundant catalysts for the chlorine evolution reaction is vital for a sustainable chlor-alkali industry. Here, the authors report a cerium modified cobalt oxide where cerium induces active site transfer from oxygen to cobalt atoms, achieving high activity and long-term stability.

Nanoreactors, with biomimetic features and distinct catalytic functions, show promise in catalytic energy conversion. Here the authors propose the utilization of precisely engineered mesoporous carbon spheres with tunable hollow sizes as nanoreactors, leveraging their catalytic functionalities for enhanced diffusion and microenvironment modulation effects to achieve efficient hydrogen peroxide electrosynthesis.

Fluorescent π-conjugated polymers are known for their superior brightness, but, thus far, their use in multiplexed molecular imaging has been negligible. Here, the authors propose POSA, a π-conjugated polymer-based amplification method, to achieve highly multiplexed signal amplification.

Perovskite solar cells with carbon electrodes offer advantages in terms of stability and manufacturing cost, but their performance remains limited. Now Wang et al. report an efficiency of 23.6% by doping the hole transport layer with graphene oxide.