Nature Search

Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment

Wnt signaling is activated in more than half of gastric cancers through a ligand-dependent manner. Here the authors show with mouse models that tumor-derived Wnt ligands activate liver stromal fibroblasts to facilitate hyaluronan accumulation in the microenvironment, promoting gastric cancer liver metastasis.

Yuichiro Furutani
Hiroko Oshima
Masanobu Oshima
ResearchOpen Access14 Feb 2026
Nature Communications

Volume: 17, P: 1-16
Optimal blood pressure levels for patients with atrial fibrillation who are on undergoing anticoagulant therapy: a large-scale real-world data (F-CREATE project)

Shintaro Ishida
Toshiki Maeda
Hisatomi Arima
Research19 Nov 2025
Hypertension Research

Volume: 49, P: 407-415
Correction: Non-fasting and fasting serum triglyceride concentrations and new-onset hyperuricemia in the general Japanese population: ISSA-CKD study

Takashi Sakaguchi
Shunsuke Funakoshi
Hisatomi Arima
Amendments and CorrectionsOpen Access10 Feb 2026
Scientific Reports

Volume: 16, P: 1
Elastic Moduli of Crystal Lattices of Poly(γ-benzyl glutamate) in the Direction Perpendicular to the Chain Axis

Shintaro Sasaki
Michiro Naka
Ichitaro Uematsu
Research01 Jun 1982
Polymer Journal

Volume: 14, P: 465-470
Structural basis for RNA slicing by a plant Argonaute

Here the authors use cryogenic electron microscopy to solve the Arabidopsis thaliana Argonaute10–guide RNA complex with and without a target RNA representing a slicing substrate, to provide insights into the slicing mechanism of a eukaryotic Argonaute.

Yao Xiao
Shintaro Maeda
Ian J. MacRae
Research01 May 2023
Nature Structural & Molecular Biology

Volume: 30, P: 778-784
Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism

In Pseudomonas aeruginosa, MexAB–OprM plays a central role in multidrug resistance by ejecting various drug compounds. Here the authors present the structure of wild-type MexAB–OprM in the presence or absence of drugs and propose mechanisms for complex formation and drug efflux.

Kenta Tsutsumi
Ryo Yonehara
Eiki Yamashita
ResearchOpen Access03 Apr 2019
Nature Communications

Volume: 10, P: 1-10
Purified F-ATP synthase forms a Ca²⁺-dependent high-conductance channel matching the mitochondrial permeability transition pore

The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. Here authors demonstrate that the membrane embedded bovine F-ATP synthase elicits Ca2 + -dependent currents matching those of the MMC/PTP.

Andrea Urbani
Valentina Giorgio
Paolo Bernardi
ResearchOpen Access25 Sept 2019
Nature Communications

Volume: 10, P: 1-11
Author Correction: Influence of NOS3 rs2070744 genotypes on hepatocellular carcinoma patients treated with lenvatinib

Shintaro Azuma
Haruki Uojima
Koichiro Atsuda
Amendments and CorrectionsOpen Access14 Apr 2021
Scientific Reports

Volume: 11, P: 1
Eating before bed and new-onset hypertension in a Japanese population: the Iki city epidemiological study of atherosclerosis and chronic kidney disease

Shunsuke Funakoshi
Atsushi Satoh
Hisatomi Arima
Research22 Sept 2021
Hypertension Research

Volume: 44, P: 1662-1667
Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction

Masato Noguchi
Akihiro Nomura
Tsuyoshi Adachi
ResearchOpen Access26 Nov 2018
Scientific Reports

Volume: 8, P: 1-8
Causes of Death in Patients with Severe Aortic Stenosis: An Observational study

Eri Minamino-Muta
Takao Kato
Takeshi Kimura
ResearchOpen Access07 Nov 2017
Scientific Reports

Volume: 7, P: 1-6
An enterococcal phage-derived enzyme suppresses graft-versus-host disease

An analysis of the intestinal microbiome of people who have undergone allogenic haematopoietic cell transplantation shows that an enzyme derived from a bacteriophage has specific antibacterial activity against Enterococcus faecalis, and suppresses E. faecalis-associated graft-versus-host disease.

Kosuke Fujimoto
Tetsuya Hayashi
Satoshi Uematsu
ResearchOpen Access10 Jul 2024
Nature

Volume: 632, P: 174-181
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

Cryo-EM analyses together with liposome and cellular assays reveal that human ATG9A forms a trimer that mediates phospholipid flipping and promotes autophagosome membrane expansion.

Shintaro Maeda
Hayashi Yamamoto
Takanori Otomo
Research26 Oct 2020
Nature Structural & Molecular Biology

Volume: 27, P: 1194-1201
The Japanese Society of Hypertension Guidelines for blood pressure control using digital technologies

Hisatomi Arima
Hiroshi Itoh
Yoshihiko Naito
Editorial05 Feb 2026
Hypertension Research

Volume: 49, P: 1087-1123
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

The FANTOM4 study identified transcriptional start sites active during proliferation arrest and differentiation of the human monocytic cell line THP-1. Systematic knockdown of 52 transcription factors provide support for their model in which a complex transcriptional network regulates the differentiation process.

Harukazu Suzuki
Alistair R R Forrest
Yoshihide Hayashizaki
Research19 Apr 2009
Nature Genetics

Volume: 41, P: 553-562
Differential brain volume between obese and underweight cognitively normal older adults with frailty in the JPSC-AD

Naoki Ishizuka
Hiroshi Akasaka
Yutaka Kiyohara
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

Toshimasa Yamauchi and colleagues report results of a genome-wide association study of type 2 diabetes in the Japanese population. They identify new risk loci at UBE2E2 and C2CD4A-C2CD4B and show that the latter is also associated with type 2 diabetes risk in Europeans.

Toshimasa Yamauchi
Kazuo Hara
Takashi Kadowaki
Research05 Sept 2010
Nature Genetics

Volume: 42, P: 864-868
Umbilical cord serum metabolomics identifies amino acid alterations associated with impaired linear growth in small for gestational age infants

Masanori Inoue
Kazuhito Sekiguchi
Kenji Ihara
ResearchOpen Access28 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Optimal blood pressure target for patients with prior stroke: A systematic review and meta-analysis

Toshiki Maeda
Yuichiro Ohya
Masatoshi Koga
Research17 Mar 2025
Hypertension Research

Volume: 48, P: 1859-1869
Non-fasting and fasting serum triglyceride concentrations and new-onset hyperuricemia in the general Japanese population: ISSA-CKD study

Takashi Sakaguchi
Shunsuke Funakoshi
Hisatomi Arima
ResearchOpen Access17 Feb 2025
Scientific Reports

Volume: 15, P: 1-8
Anemia in Patients with Severe Aortic Stenosis

Kazuya Nagao
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis

Norio Kanamori
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access04 Jul 2018
Scientific Reports

Volume: 8, P: 1-10
Serum triglyceride levels and incidence of hypertension in a general Japanese population: ISSA-CKD study

Casual serum triglyceride levels and incidence of hypertension in a general Japanese population: ISSA-CKD study.

Shintaro Ishida
Seiji Kondo
Hisatomi Arima
Research24 Jan 2023
Hypertension Research

Volume: 46, P: 1122-1131
Association between class of foundational medication for heart failure and prognosis in heart failure with reduced/mildly reduced ejection fraction

Miyuki Ito
Daichi Maeda
Tohru Minamino
ResearchOpen Access05 Oct 2022
Scientific Reports

Volume: 12, P: 1-9
Phenotypic and genotypic features of the Mycobacterium tuberculosis lineage 1 subgroup in central Vietnam

Nguyen Thi Le Hang
Minako Hijikata
Seiya Kato
ResearchOpen Access30 Jun 2021
Scientific Reports

Volume: 11, P: 1-12
Influence of NOS3 rs2070744 genotypes on hepatocellular carcinoma patients treated with lenvatinib

Shintaro Azuma
Haruki Uojima
Koichiro Atsuda
ResearchOpen Access13 Oct 2020
Scientific Reports

Volume: 10, P: 1-11
Whole genome sequencing, analyses of drug resistance-conferring mutations, and correlation with transmission of Mycobacterium tuberculosis carrying katG-S315T in Hanoi, Vietnam

Nguyen Thi Le Hang
Minako Hijikata
Naoto Keicho
ResearchOpen Access25 Oct 2019
Scientific Reports

Volume: 9, P: 1-14
Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia

Shutaro Shibata
Moeko Noguchi-Shinohara
Yutaka Kiyohara
ResearchOpen Access07 Jan 2025
npj Science of Food

Volume: 9, P: 1-8
Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells

Ken Morita
Mina Noura
Yasuhiko Kamikubo
ResearchOpen Access30 Nov 2017
Scientific Reports

Volume: 7, P: 1-12
Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD)

Ayumi Tachibana
Jun-ichi Iga
Yutaka Kiyohara
ResearchOpen Access28 Mar 2024
Scientific Reports

Volume: 14, P: 1-9
Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice

Kengo Azushima
Kazushi Uneda
Kouichi Tamura
ResearchOpen Access17 Apr 2019
Scientific Reports

Volume: 9, P: 1-10
Mechano-synthesized orange TiO₂ shows significant photocatalysis under visible light

Ken-ichi Saitow
Yufeng Wang
Shintaro Takahashi
ResearchOpen Access19 Oct 2018
Scientific Reports

Volume: 8, P: 1-10
Effects of Rikkunshito treatment on renal fibrosis/inflammation and body weight reduction in a unilateral ureteral obstruction model in mice

Hiromichi Wakui
Takahiro Yamaji
Kouichi Tamura
ResearchOpen Access05 Feb 2020
Scientific Reports

Volume: 10, P: 1-11
An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice

Shintaro Minegishi
Tomoaki Ishigami
Satoshi Umemura
ResearchOpen Access03 Jun 2016
Scientific Reports

Volume: 6, P: 1-13

Search

Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment

Optimal blood pressure levels for patients with atrial fibrillation who are on undergoing anticoagulant therapy: a large-scale real-world data (F-CREATE project)

Correction: Non-fasting and fasting serum triglyceride concentrations and new-onset hyperuricemia in the general Japanese population: ISSA-CKD study

Elastic Moduli of Crystal Lattices of Poly(γ-benzyl glutamate) in the Direction Perpendicular to the Chain Axis

Structural basis for RNA slicing by a plant Argonaute

Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism

Purified F-ATP synthase forms a Ca²⁺-dependent high-conductance channel matching the mitochondrial permeability transition pore

Author Correction: Influence of NOS3 rs2070744 genotypes on hepatocellular carcinoma patients treated with lenvatinib

Eating before bed and new-onset hypertension in a Japanese population: the Iki city epidemiological study of atherosclerosis and chronic kidney disease

Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction

Causes of Death in Patients with Severe Aortic Stenosis: An Observational study

An enterococcal phage-derived enzyme suppresses graft-versus-host disease

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

The Japanese Society of Hypertension Guidelines for blood pressure control using digital technologies

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

Differential brain volume between obese and underweight cognitively normal older adults with frailty in the JPSC-AD

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

Umbilical cord serum metabolomics identifies amino acid alterations associated with impaired linear growth in small for gestational age infants

Optimal blood pressure target for patients with prior stroke: A systematic review and meta-analysis

Non-fasting and fasting serum triglyceride concentrations and new-onset hyperuricemia in the general Japanese population: ISSA-CKD study

Anemia in Patients with Severe Aortic Stenosis

Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis

Serum triglyceride levels and incidence of hypertension in a general Japanese population: ISSA-CKD study

Association between class of foundational medication for heart failure and prognosis in heart failure with reduced/mildly reduced ejection fraction

Phenotypic and genotypic features of the Mycobacterium tuberculosis lineage 1 subgroup in central Vietnam

Influence of NOS3 rs2070744 genotypes on hepatocellular carcinoma patients treated with lenvatinib

Whole genome sequencing, analyses of drug resistance-conferring mutations, and correlation with transmission of Mycobacterium tuberculosis carrying katG-S315T in Hanoi, Vietnam

Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia

Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells

Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD)

Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice

Mechano-synthesized orange TiO₂ shows significant photocatalysis under visible light

Effects of Rikkunshito treatment on renal fibrosis/inflammation and body weight reduction in a unilateral ureteral obstruction model in mice

An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice

Search

Quick links

Search

Filter By:

Search

Quick links