Hosaka et al. show that selection of bacteria for antibiotic resistance can be used to discover new antibacterials. Some of the mutant strains they generated, which bear mutations in RNA polymerase and in a ribosomal protein, produce a previously unknown class of antibacterial called piperidamycin.
- Takeshi Hosaka
- Mayumi Ohnishi-Kameyama
- Kozo Ochi
