Hepatic ischemia reperfusion injury (HIRI) is a common complication after hepatectomy and liver transplantation. Here, the authors show that Axin1 exacerbates HIRI by promoting PPARβ ubiquitination and degradation via E3 ubiquitin ligase RBBP6, activating the NF-κB pathway, and may be a potential therapeutic target.
- Baolin Qian
- Bing Yin
- Yong Ma
